Comparative Analysis of DNA Methylome Conservation Across Species

Dr. Helene Kretzmer & Prof. Dr. Alexander Meissner

The combined interest and focus of the Meissner and Kretzmer labs is to understand the fundamental mechanisms that underlie epigenetic genome regulation. The DNA methylome, a critical component of epigenetic regulation, plays a central role in modulating gene expression and cellular identity. Recent advances in high-throughput sequencing technologies have opened exciting possibilities for examining DNA methylation patterns across various species, including placental and non-placental animals. However, the extent to which specific DNA methylation patterns, as found in cancer but also in the placenta, are conserved or newly established across organisms remains an open question.

For more information visit the website of the Computational Genomics Group.