Sofja Kovaleskaja Research Group Stem Cell Chromatin
Embyonic development relies on coordinated stem cell function on balance with differentiation. Our lab focuses on mechanisms regulating stem cell state transitions and fate commitment. Specifically, we study how cells communicate signals from their surroundings to the gene expression machinery, especially in the context of cell fate decisions in development and disease. By combining the latest functional perturbation methods in stem cells and the early mouse embryo with omics, imaging, and biochemistry; we aim to reveal how genetic networks are adjusted to the status of the embryo.