Bulut-Karslıoğlu lab / Stem Cell Chromatin Group

A diapaused mouse embryo. Pluripotent cells are shown in red.

Our lab studies the molecular mechanisms of chromatin and gene regulation in stem cells and in the developing embryo. Specifically, we aim to dissect the crosstalk between signaling and chromatin in pluripotent stem cells. Our research strategy integrates in vivo and in vitro techniques, biochemistry, imaging, molecular and developmental biology to study the above questions. Metabolo-epigenetic regulation is widely relevant to numerous cell types across organisms, particularly to stem/progenitor populations at the forefront of quiescence vs proliferation decisions in embryonic and adult tissues and disease states. By employing other stem cell models such as neural stem/progenitor cells, we aim to uncover regulatory pathways critical for the timing of proliferation across mammalian stem cells.

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