Contact

Aydan Bulut-Karslioglu, PhD
Aydan Bulut-Karslioglu, PhD
Research Group Leader
Phone: (030) 8413 1126
Room: 2.3.08

Bulut-Karslioglu lab

Bulut-Karslioglu lab /Stem Cell Chromatin Group

A diapaused mouse embryo. Pluripotent cells are shown in red. Zoom Image
A diapaused mouse embryo. Pluripotent cells are shown in red. [less]

Our lab studies the molecular mechanisms of chromatin and gene regulation in stem cells and in the developing embryo. Specifically, we aim to dissect the crosstalk between metabolism and chromatin in pluripotent stem cells. Our research strategy integrates in vivo and in vitro techniques, biochemistry, imaging, molecular and developmental biology to study the above questions. Metabolo-epigenetic regulation is widely relevant to numerous cell types across organisms, particularly to stem/progenitor populations at the forefront of quiescence vs proliferation decisions in embryonic and adult tissues and disease states. By employing other stem cell models such as neural stem/progenitor cells, we aim to uncover regulatory pathways critical for the timing of proliferation across mammalian stem cells.

 
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