Chromatin regulation in stem cells and development
Dr. Aydan Bulut-Karslioglu
Embryonic development relies on coordinated stem cell function on balance with differentiation. Our lab focuses on mechanisms regulating stem cell state transitions and fate commitment. Specifically, we study how cells communicate signals from their surroundings to the gene expression machinery, especially in the context of cell fate decisions in development. By combining the latest functional perturbation methods in stem cells and the early mouse embryo with omics, imaging, and biochemistry, we aim to reveal how genetic networks are adjusted to the growth status of the embryo and how memory of cellular identity is propagated during periods of dormancy. This year, we are looking to recruit an experimental or computational doctoral candidate to join our team.
For our most recent papers, see:
*mTOR activity paces human blastocyst stage developmental progression, Iyer, D. P., Khoei, H. H., van der Weijden, V. A., Kagawa, H., Pradhan, S. J., Novatchkova, M., McCarthy, A., Rayon, T., Simon, C. S., Dunkel, I., Wamaitha, S. E., Elder, K., Snell, P., Christie, L., Schulz, E. G., Niakan, K. K., Rivron, N., & Bulut-Karslioğlu, A. (2024). Cell. https://doi.org/https://doi.org/10.1016/j.cell.2024.08.048
*TET activity safeguards pluripotency throughout embryonic dormancy, Stötzel, M., Cheng, C.-Y., Iiik, I. A., Kumar, A. S., Omgba, P. A., van der Weijden, V. A., Zhang, Y., Vingron, M., Meissner, A., Aktaş, T., Kretzmer, H., & Bulut-Karslioğlu, A. (2024). Nature Structural & Molecular Biology. https://doi.org/10.1038/s41594-024-01313-7
*Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy, Iyer*, D. P., Moyon*, L., Wittler, L., Cheng, C. Y., Ringeling, F. R., Canzar, S., Marsico, A., & Bulut-Karslioglu, A. (2024). Genome Res. https://doi.org/10.1101/gr.278662.123
*FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy, van der Weijden, V. A., Stotzel, M., Iyer, D. P., Fauler, B., Gralinska, E., Shahraz, M., Meierhofer, D., Vingron, M., Rulands, S., Alexandrov, T., Mielke, T., & Bulut-Karslioglu, A. (2024). Nat Cell Biol, 26(2), 181-193. https://doi.org/10.1038/s41556-023-01325-3
* Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids, López-Anguita N, Gassaloglu SI, Stötzel M, Bolondi A, Conkar D, Typou M, Buschow R, Veenvliet JV, Bulut-Karslioglu A. (2022). Development, 149(20):dev200679. doi: 10.1242/dev.200679. Epub 2022 Sep 14. PMID: 36102628
For more information visit the website of the Bulut-Karslioglu lab (Stem Cell Chromatin Group).
© A. Bulut-Karslioglu
