The Department of Developmental Genetics is focused on understanding how regulatory genes acting in stem cells cooperate to conduct the generation of several different cell types forming complex tissues and organs from their descendants. Our model system is the trunk of the mouse. We investigate genetic and epigenetic aspects of gene regulatory networks, utilizing state-of-the-art technology such as massively parallel sequencing. A recent topic is the role of long non-coding RNA. In addition, we investigate mechanisms of early tumor formation caused by aberrant tissue homeostasis, and the molecular basis of “transmission ratio distortion” (TRD), a particular phenomenon of non-Mendelian inheritance discovered in the mouse.