The Meissner Lab is a mixed group of experimental and computational biologists that uses genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation. Their work utilizes early mouse development as well as various mouse and human stem cell paradigms to dissect basic molecular mechanisms including the role of DNA methylation and other epigenetic modifications in gene and genome regulation.
This plot shows the dynamic methylation landscape of the human genome, where the x axis (left) corresponds to the maximal observed methylation change across 24 human cell and tissue types, y is the median total methylation and z is the density of CpG dinucleotides. The methylation of cytosine, usually at CpGs, is a common feature of epigenetic regulation of gene expression. Most cell types have relatively stable CpG dinucleotide methylation patterns and our understanding of which CpGs participate in genomic regulation is still relatively limited.
Image by Bang Wong and Michael Ziller. Used as cover image for Nature Volume 500 Issue 7463
This plot shows the dynamic methylation landscape of the human genome, where the x axis (left) corresponds to the maximal observed methylation change across 24 human cell and tissue types, y is the median total methylation and z is the density of CpG dinucleotides. The methylation of cytosine, usually at CpGs, is a common feature of epigenetic regulation of gene expression. Most cell types have relatively stable CpG dinucleotide methylation patterns and our understanding of which CpGs participate in genomic regulation is still relatively limited.
Image by Bang Wong and Michael Ziller. Used as cover image for Nature Volume 500 Issue 7463
Cassandra Extavour is a developmental biologist and a professor of molecular and cell biology at Harvard. On the occasion of her talk at our institute in May, we interviewed her about her scientific journey, inclusion in academia, and how her second career as a part-time soprano singer shapes her scientific work. The interview was conducted by…
Alexander Meissner and Aydan Bulut-Karslioglu from Max Planck Institute for Molecular Genetics participate in a new cluster of excellence: ImmunoPreCept.
An international team of scientists from the MPIMG, University Medical Center Schleswig-Holstein (UKSH) and the San Diego Zoo Wildlife Alliance (SDWA) have decoded the nearly complete genome of the northern white rhinoceros.