Michael J. Ziller, Juan A. Ortega, Katharina A. Quinlan, David P. Santos, Hongcang Gu, Eric J. Martin, Christina Galonska, Ramona Pop, Susanne Maidl, Alba Di Pardo, Mei Huang, Herbert Y. Meltzer, Andreas Gnirke, C.J. Heckman, Alexander Meissner & Evangelos Kiskinis

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology

Cell Stem Cell 22, 1–16, 05.04.2018, Elsevier Inc.
doi: https://doi.org/10.1016/j.stem.2018.02.012

Jocelyn Charlton, Timothy L. Downing, Zachary D. Smith, Hongcang Gu, Kendell Clement, Ramona Pop, Veronika Akopian, Sven Klages, David P. Santos, Alexander M. Tsankov, Bernd Timmermann, Michael J. Ziller, Evangelos Kiskinis, Andreas Gnirke & Alexander Meissner

Global delay in nascent strand DNA methylation

Nature Structural & Molecular Biology (2018), online publication 12.03.2018
doi:10.1038/s41594-018-0046-4

Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller & Alexander Meissner

Genome-wide tracking of dCas9-methyltransferase footprints

Nature Communications 9(597), online publication 09.02.2018
doi:10.1038/s41467-017-02708-5

Julie Donaghey, Sudhir Thakurela, Jocelyn Charlton, Jennifer S. Chen, Zachary D. Smith, Hongcang Gu, Ramona Pop, Kendell Clement, Elena K. Stamenova, Rahul Karnik, David R. Kelley, Casey A. Gifford, Davide Cacchiarelli, John L. Rinn, Andreas Gnirke, Michael J. Ziller & Alexander Meissner

Genetic determinants and epigenetic effects of pioneer-factor occupancy

Nature Genetics 50, 250–258, online publication 22.01.2018
doi:10.1038/s41588-017-0034-3

Zachary D. Smith, Jiantao Shi, Hongcang Gu, Julie Donaghey, Kendell Clement, Davide Cacchiarelli, Andreas Gnirke, Franziska Michor & Alexander Meissner

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Nature (2017), online publication Sept 20, 2017, doi:10.1038/nature23891

Meissner lab

Meissner Lab / Genome Regulation Group

The Genome Regulation Group is a mixed group of experimental and computational biologists that uses genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation. Their work utilizes early mouse development as well as various mouse and human stem cell paradigms to dissect basic molecular mechanisms including the role of DNA methylation and other epigenetic modifications in gene and genome regulation.

<p>This plot shows the dynamic methylation landscape of the human genome, where the <em>x</em> axis (left) corresponds to the maximal observed methylation change across 24 human cell and tissue types, <em>y</em> is the median total methylation and <em>z</em> is the density of CpG dinucleotides. The methylation of cytosine, usually at CpGs, is a common feature of epigenetic regulation of gene expression. Most cell types have relatively stable CpG dinucleotide methylation patterns and our understanding of which CpGs participate in genomic regulation is still relatively limited.</p>

Zoom Image

This plot shows the dynamic methylation landscape of the human genome, where the x axis (left) corresponds to the maximal observed methylation change across 24 human cell and tissue types, y is the median total methylation and z is the density of CpG dinucleotides. The methylation of cytosine, usually at CpGs, is a common feature of epigenetic regulation of gene expression. Most cell types have relatively stable CpG dinucleotide methylation patterns and our understanding of which CpGs participate in genomic regulation is still relatively limited.

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Image by Bang Wong and Michael Ziller. Used as cover image for Nature Volume 500 Issue 7463