Computational biology studies biological questions with mathematical and computational methods. In the area of molecular biology and genomics, the possibility to apply such formal methods, of course, comes from the availability not only of genome sequences, but also of large amounts of functional data about cellular processes. Computational molecular biology encompasses both development and adaptation of methods in the areas of mathematics, statistics, and computer science, as well as pursuing biological questions applying these tools and close collaborations with experimentalists. The research interest of the Computational Molecular Biology Department lies in understanding gene regulatory mechanisms in the context of structure and evolution of the eukaryotic genome. To this end, mathematical, computational, and also experimental approaches are being developed and employed. Within the MPIMG, computational approaches have also become an integral part of many of the research projects pursued.