Computational Genomics

 

Our specific research interest is in developmental scenarios where the regulation of the genome changes, focusing on the molecular cause and consequence. Why do these epigenomes change so dramatically and what enzymes are responsible? We are particularly interested in the early stages of mammalian development, B cell maturation, and cancer, as these processes are marked by genome-wide epigenetic programming.

 

We tackle biological questions computationally and work closely with experimental and clinical scientists. Our main expertise is in integrating multiple forms of next- and third-generation sequencing data, including large single-cell, epigenomic, and long-read Nanopore data, to better understand how genome regulation changes to support various developmental processes or malignant transformation. To this end, we develop algorithms and methods for advanced data integration and obtain novel readouts from cutting-edge technologies.

 

At the MPIMG, we work closely with several labs at the institute, especially Alexander Meissner's lab. We are open to creative, collaborative project ideas with other labs and strongly support an interdisciplinary, supportive, and friendly work environment.