Department of Genome Regulation

Head: Alexander Meissner

Meissner lab / Genome Regulation Group

The Genome Regulation Group is a mixed group of experimental and computational biologists that uses genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation. more

Bulut-Karslioglu lab / Stem Cell Chromatin Group

The Bulut-Karslioglu lab aims to dissect the crosstalk between metabolism and chromatin in pluripotent stem cells. Our research strategy integrates in vivo and in vitro techniques, biochemistry, imaging, molecular and developmental biology to study the above questions. more

Elkabetz lab / Lab for Human Brain & Neural Stem Cell Studies

In the lab for Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain development. more

Hnisz lab / Precision Gene Control group

We discover and investigate principles and mechanisms for selective activation and repression of genes that play essential roles in development and disease. more

Müller lab / Cellular Phenotyping Group

We explore ways to define cellular phenotypes, developmental states and disease processes with genome wide measurements.

LATEST PUBLICATIONS

Michael J. Ziller, Juan A. Ortega, Katharina A. Quinlan, David P. Santos, Hongcang Gu, Eric J. Martin, Christina Galonska, Ramona Pop, Susanne Maidl, Alba Di Pardo, Mei Huang, Herbert Y. Meltzer, Andreas Gnirke, C.J. Heckman, Alexander Meissner & Evangelos Kiskinis

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology

Cell Stem Cell 22, 1–16, 05.04.2018, Elsevier Inc.
doi: https://doi.org/10.1016/j.stem.2018.02.012

Jocelyn Charlton, Timothy L. Downing, Zachary D. Smith, Hongcang Gu, Kendell Clement, Ramona Pop, Veronika Akopian, Sven Klages, David P. Santos, Alexander M. Tsankov, Bernd Timmermann, Michael J. Ziller, Evangelos Kiskinis, Andreas Gnirke & Alexander Meissner

Global delay in nascent strand DNA methylation

Nature Structural & Molecular Biology (2018), online publication 12.03.2018
doi:10.1038/s41594-018-0046-4

Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller & Alexander Meissner

Genome-wide tracking of dCas9-methyltransferase footprints

Nature Communications 9(597), online publication 09.02.2018
doi:10.1038/s41467-017-02708-5

Julie Donaghey, Sudhir Thakurela, Jocelyn Charlton, Jennifer S. Chen, Zachary D. Smith, Hongcang Gu, Ramona Pop, Kendell Clement, Elena K. Stamenova, Rahul Karnik, David R. Kelley, Casey A. Gifford, Davide Cacchiarelli, John L. Rinn, Andreas Gnirke, Michael J. Ziller & Alexander Meissner

Genetic determinants and epigenetic effects of pioneer-factor occupancy

Nature Genetics 50, 250–258, online publication 22.01.2018
doi:10.1038/s41588-017-0034-3

Zachary D. Smith, Jiantao Shi, Hongcang Gu, Julie Donaghey, Kendell Clement, Davide Cacchiarelli, Andreas Gnirke, Franziska Michor & Alexander Meissner

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Nature (2017), online publication Sept 20, 2017, doi:10.1038/nature23891