- Genome Regulation
Department of Genome Regulation (Alexander Meissner)
The Genome Regulation Group is a mixed group of experimental and computational biologists that uses genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation.
The Bulut-Karslioglu lab aims to dissect the crosstalk between metabolism and chromatin in pluripotent stem cells. Our research strategy integrates in vivo
and in vitro
techniques, biochemistry, imaging, molecular and developmental biology to study the above questions.
In the lab for Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain development.
We discover and investigate principles and mechanisms for selective activation and repression of genes that play essential roles in development and disease.
We explore ways to define cellular phenotypes, developmental states and disease processes with genome wide measurements.
Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
Cell Stem Cell 22, 1–16, 05.04.2018, Elsevier Inc.
Global delay in nascent strand DNA methylation
Nature Structural & Molecular Biology (2018), online publication 12.03.2018
Genome-wide tracking of dCas9-methyltransferase footprints
Nature Communications 9(597), online publication 09.02.2018
Genetic determinants and epigenetic effects of pioneer-factor occupancy
Nature Genetics 50, 250–258, online publication 22.01.2018
Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer
Nature (2017), online publication Sept 20, 2017, doi:10.1038/nature23891