Department of Genome Regulation

Head: Alexander Meissner

The Genome Regulation Group is a mixed group of experimental and computational biologists that uses genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation. more
The Bulut-Karslioglu lab aims to dissect the crosstalk between metabolism and chromatin in pluripotent stem cells.  Our research strategy integrates in vivo and in vitro techniques, biochemistry, imaging, molecular and developmental biology to study the above questions. more
In the lab for Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain development. more
We discover and investigate principles and mechanisms for selective activation and repression of genes that play essential roles in development and disease. more
We explore ways to define cellular phenotypes, developmental states and disease processes with genome wide measurements. more


Alvarez-Dominguez JR, Donaghey J, Rasouli N, Kenty JHR, Helman A, Charlton J, Straubhaar JR, Meissner A, Melton DA.
Circadian Entrainment Triggers Maturation of Human In Vitro Islets.        
Cell Stem Cell. 2020 Jan 2;26(1):108-122.e10. doi: 10.1016/j.stem.2019.11.011. Epub 2019 Dec 12.
Giesselmann P, Brändl B, Raimondeau E, Bowen R, Rohrandt C, Tandon R, Kretzmer H, Assum G, Galonska C, Siebert R, Ammerpohl O, Heron A, Schneider SA, Ladewig J, Koch P, Schuldt BM, Graham JE, Meissner A, Müller FJ.
Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing.
Nat Biotechnol. 2019 Dec;37(12):1478-1481. doi: 10.1038/s41587-019-0293-x. Epub 2019 Nov 18.
Andergassen D, Smith ZD, Lewandowski JP, Gerhardinger C, Meissner A, Rinn JL.
In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation.
Elife. 2019 Nov 18;8. pii: e47214. doi: 10.7554/eLife.47214.
Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N.
Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Nature. 2019 Nov;575(7783):E5. doi: 10.1038/s41586-019-1696-z.
Brumbaugh J, Kim IS, Ji F, Huebner AJ, Di Stefano B, Schwarz BA, Charlton J, Coffey A, Choi J, Walsh RM, Schindler JW, Anselmo A, Meissner A, Sadreyev RI, Bernstein BE, Hock H, Hochedlinger K.
Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.
Nat Cell Biol. 2019 Nov;21(11):1449-1461. doi: 10.1038/s41556-019-0403-5. Epub 2019 Oct 28.

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