Publications of Edda G. Schulz

de Sousa, J. A.; Wong, C.-W.; Dunkel, I.; Owens, T.; Voigt, P.; Hodgson, A.; Baker, D.; Schulz, E. G.; Reik, W.; Smith, A. et al.; Rostovskaya, M.; von Meyenn, F.: Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science Advances 9 (39), eadg1936 (2023)

Sultana, Z.; Dorel, M.; Klinger, B.; Sieber, A.; Dunkel, I.; Blüthgen, N.; Schulz, E. G.: Modeling unveils sex differences of signaling networks in mouse embryonic stem cells. Molecular Systems Biology, e11510 (2023)

Noviello, G.; Gjaltema, R. A. F.; Schulz, E. G.: CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications 14 (1), 3225 (2023)

Gjaltema, R.; Schwämmle, T.; Kautz, P.; Robson, M.; Schöpflin, R.; Lustig, L. R.; Brandenburg, L.; Dunkel, I.; Vechiatto, C.; Ntini, E. et al.; Mutzel, V.; Schmiedel, V.; Marsico, A.; Mundlos, S.; Schulz, E. G.: Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus. Molecular Cell 82 (1), pp. 190 - 208 (2022)

Pacini, G.; Dunkel, I.; Mages, N.; Mutzel, V.; Timmermann, B.; Marsico, A.; Schulz, E. G.: Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution. Nature Communications 12 (1), 3638 (2021)

Genolet, O.; Monaco, A. A.; Dunkel, I.; Boettcher, M.; Schulz, E. G.: Identification of X-chromosomal genes that drive global X-dosage effects in mammals. Genome Biology 22, 110 (2021)

Mutzel, V.; Schulz, E. G.: Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation. Bioessays 42 (4), e1900163 (2020)

Barros de Andrade e Sousa, L.; Jonkers, I.; Syx, L.; Dunkel, I.; Chaumeil, J.; Picard, C.; Foret, B.; Chen, C.-J.; Lis, J. T.; Heard, E. et al.; Schulz, E. G.; Marsico, A.: Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Research 29 (7), pp. 1087 - 1099 (2019)

Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural and Molecular Biology 26 (5), pp. 350 - 360 (2019)

Schulz, E. G.: X-chromosome dosage as a modulator of pluripotency, signalling and differentiation? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 372 (1733), pii: 20160366 (2017)

Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X-chromosome inactivation. bioRxive 2017, pp. 1 - 54 (2017)

Zhan, Y.; Mariani, L.; Barozzi, I.; Schulz, E. G.; Blüthgen, N.; Stadler, M.; Tiana, G.; Giorgetti, L.: Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Research 27 (3), pp. 479 - 490 (2017)

Schulz, E. G.; Meisig, J.; Nakamura, T.; Okamoto, I.; Sieber, A.; Picard, C.; Borensztein, M.; Saitou, M.; Blüthgen, N.; Heard, E.: The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network. Cell Stem Cell 14 (2), pp. 203 - 2016 (2014)

Schulz, E. G.; Heard, E.: Role and control of X chromosome dosage in mammalian development. Current Opinion in Genetics & Development 23 (2), pp. 109 - 115 (2013)

Nora, E. P.; Lajoie, B. R.; Schulz, E. G.; Giorgetti, L.; Okamoto, I.; Servant, N.; Piolot, T.; van Berkum, N. L.; Meisig, J.; Sedat, J. et al.; Gribnau, J.; Barillot, E.; Blüthgen, N.; Dekker, J.; Heard, E.: Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 485 (7398), pp. 381 - 385 (2012)

Schulz, E. G.; Elphège , P. N.; Heard, E.: Rnf12 – A Jack of All Trades in X Inactivation. PLoS Genetics 7 (1), e1002002 (2011)

Schulz, E. G.; Nora, E. P.; Heard, E.: Rnf12--a jack of all trades in X inactivation? PLoS Genetics 7 (1), e1002002 (2011)

Schulz, E. G.; Mariani, L.; Radbruch, A.; Höfer, T.: Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12. Immunity 30 (5), pp. 673 - 683 (2009)

Genolet, O.; Ravid-Lustig, L.; Schulz, E. G.: Dissecting molecular phenotypes through FACS-based pooled CRISPR screens. In: Embryonic Stem Cell Protocols. Methods in Molecular Biology, 2520., Vol. 2520, pp. 1 - 24 (Ed. Turksen, K.). Humana Press, New York, NY (2022)

Iyer, D. P.; van der Weijden, V. A.; Khoei, H. H.; McCarthy, A.; Rayon, T.; Simon, C. S.; Dunkel, I.; Wamaitha, S. E.; Elder, K.; Snell, P. et al.; Christie, L.; Schulz, E. G.; Niakan, K. K.; Rivron, N.; Bulut-Karslioglu, A.: Delay of human early development via in vitro diapause. (2023)