Publications of Hans Lehrach

Sudheer, S.; Bhushan, R.; Fauler, B.; Lehrach, H.; Adjaye, J.: FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells and Development 21 (16), pp. 2987 - 3000 (2012)

Odoardi, F.; Sie, C.; Streyl, K.; Ulaganathan, V. K.; Schlaeger, C.; Lodygin, D.; Heckelsmiller, K.; Nietfeld, W.; Ellwart, J.; Klinkert, W. E. F. et al.; Lottaz, C.; Nosov, M.; Brinkmann, V.; Spang, R.; Lehrach, H.; Vingron, M.; Wekerle, H.; Fluegel-Koch, C.; Fluegel, A.: T cells become licensed in the lung to enter the central nervous system. Nature 488 (7413), pp. 675 - 679 (2012)

Wierling, C.; Kühn, A.; Hache, H.; Daskalaki, A.; Maschke-Dutz, E.; Peycheva, S.; Li, J.; Herwig, R.; Lehrach, H.: Prediction in the face of uncertainty: a Monte Carlo-based approach for systems biology of cancer treatment. Mutation Research-Genetic Toxixology and Environmental Mutagenesis 746 (2), pp. 163 - 170 (2012)

Ralser, M.; Kuhl, H.; Ralser, M.; Werber, M.; Lehrach, H.; Breitenbach, M.; Timmermann, B.: The Saccharomyces cerevisiae W303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt. Open Biology 2 (8), 120093 (2012)

Sultan, M.; Dokel, S.; Amstislavskiy, V.; Wuttig, D.; Sultmann, H.; Lehrach, H.; Yaspo, M. L.: A simple strand-specific RNA-Seq library preparation protocol combining the Illumina TruSeq RNA and the dUTP methods. Biochemical and Biophysical Research Communications 422 (4), pp. 643 - 646 (2012)

Drews, K.; Tavernier, G.; Demeester, J.; Lehrach, H.; de Smedt, S. C.; Rejman, J.; Adjaye, J.: The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. Biomaterials 33 (16), pp. 4059 - 4068 (2012)

Querfurth, R.; Fischer, A.; Schweiger, M. R.; Lehrach, H.; Mertes, F.: Creation and application of immortalized bait libraries for targeted enrichment and next-generation sequencing. Biotechniques 52 (6), pp. 375 - 380 (2012)

Welzel, F.; Kaehler, C.; Isau, M.; Hallen, L.; Lehrach, H.; Krobitsch, S.: FOX-2 dependent splicing of ataxin-2 transcript is affected by ataxin-1 overexpression. PLoS One 7 (5), p. e37985 - e37985 (2012)

Dreher, F.; Kreitler, T.; Hardt, C.; Kamburov, A.; Yildirimman, R.; Schellander, K.; Lehrach, H.; Lange, B. M. H.; Herwig, R.: DIPSBC--data integration platform for systems biology collaborations. BMC Bioinformatics 13, 13:85 (2012)

Dohm, J. C.; Lange, C.; Holtgräwe, D.; Sörensen, T. R.; Borchardt, D.; Schulz, B.; Lehrach, H.; Weisshaar, B.; Himmelbauer, H.: Palaeohexaploid ancestry for Caryophyllales inferred from extensive gene-based physical and genetic mapping of the sugar beet genome (Beta vulgaris). The Plant Journal 70 (3), pp. 528 - 540 (2012)

The 1000 Genomes Project Consortium; Sudbrak, R.; Albrecht, M.; Amstislavskiy, V.; Borodina, T. A.; Dahl, A.; Davydov, A.; Herwig, R.; Marquardt, P.; Mertes, F. et al.; Nietfeld, W.; Parkhomchuk, D.; Soldatov, A.; Timmermann, B.; Tolzmann, M.; Lehrach, H.: The 1000 Genomes Project: data management and community access. Nature methods 9 (5), pp. 459 - 462 (2012)

Lill, C. M.; Roehr, C.; McQueen, M. B.; Kavvoura, F. K.; Bagade, S.; Schjeide, B.-M.; Schjeide, L.; Meissner, E.; Zauft, U.; Allen, N. C. et al.; Liu, T.; Schilling, M.; Anderson, K. J.; Beecham, G.; Berg, D.; Biernacka, J. M.; Brice, A.; DeStefano, A. L.; Do, C. B.; Eriksson, N.; Factor, S. A.; Farrer, M. J.; Foroud, T.; Gasser, T.; Hamza, T.; Hardy, J. A.; Heutink, P.; Hill-Burns, E. M.; Klein, C.; Latourelle, J. C.; Maraganore, D. M.; Martin, E. R.; Martinez, M.; Myers, R. H.; Nalls, M. A.; Pankratz, N.; Payami, H.; Satake, W.; Scott, W. K.; Sharma, M.; Singleton, A. B.; Stefansson, K.; Toda, T.; Tung, J. Y.; Vance, J.; Wood, N. W.; Zabetian, C. P.; Young, P.; Tanzi, R. E.; Khoury, M. J.; Zipp, F.; Lehrach, H.; Ioannidis, J. P. A.; Bertram, L.; Parkinson's, G. E.; IPDGC; Consortium, P. D. G.; WTCCC2: Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database. PLoS Genetics 8 (3), p. e1002548 (2012)

Eberl, M.; Klingler, S.; Mangelberger, D.; Loipetzberger, A.; Damhofer, H.; Zoidl, K.; Schnidar, H.; Hache, H.; Bauer, H. C.; Solca, F. et al.; Hauser-Kronberger, C.; Ermilov, A. N.; Verhaegen, M. E.; Bichakjian, C. K.; Dlugosz, A. A.; Nietfeld, W.; Sibilia, M.; Lehrach, H.; Wierling, C.; Aberger, F.: Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Molecular Medicine 4 (3), pp. 218 - 233 (2012)

MacArthur, D. G.; Balasubramanian, S.; Frankish, A.; 1000 Genomes Project, C.; Sudbrak, R.; Albrecht , M. W.; Amstislavskiy, V.; Borodina, T. A.; Dahl, A.; Davydov, A. et al.; Herwig, R.; Marquardt, P.; Mertes, F.; Nietfeld, W.; Parkhomchuk, D.; Soldatov, A.; Timmermann, B.; Tolzmann, M.; Lehrach, H.: A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes. Science 335 (6070), pp. 823 - 828 (2012)

Li, J.; Pandey, V.; Kessler, T.; Lehrach, H.; Wierling, C.: Modeling of miRNA and drug action in the EGFR signaling pathway. PLoS One 7 (1), e30140 (2012)

Adams, D.; Altucci, L.; Antonarakis, S. E.; Ballesteros, J.; Beck, S.; Bird, A.; Bock, C.; Boehm, B.; Campo, E.; Caricasole, A. et al.; Dahl, F.; Dermitzakis, E. T.; Enver, T.; Esteller, M.; Estivill, X.; Ferguson-Smith, A.; Fitzgibbon, J.; Flicek, P.; Giehl, C.; Graf, T.; Grosveld, F.; Guigo, R.; Gut, I.; Helin, K.; Jarvius, J.; Kuppers, R.; Lehrach, H.; Lengauer, T.; Lernmark, A.; Leslie, D.; Loeffler, M.; Macintyre, E.; Mai, A.; Martens, J. H.; Minucci, S.; Ouwehand, W. H.; Pelicci, P. G.; Pendeville, H.; Porse, B.; Rakyan, V.; Reik, W.; Schrappe, M.; Schubeler, D.; Seifert, M.; Siebert, R.; Simmons, D.; Soranzo, N.; Spicuglia, S.; Stratton, M.; Stunnenberg, H. G.; Tanay, A.; Torrents, D.; Valencia, A.; Vellenga, E.; Vingron, M.; Walter, J.; Willcocks, S.: BLUEPRINT to decode the epigenetic signature written in blood. Nature biotechnology 30 (3), pp. 224 - 226 (2012)

Barberis, M.; Linke, C.; Adrover, M. A.; Gonzalez-Novo, A.; Lehrach, H.; Krobitsch, S.; Posas, F.; Klipp, E.: Sic1 plays a role in timing and oscillatory behaviour of B-type cyclins. Biotechnol Adv 30 (1), pp. 108 - 130 (2012)

Harvey, A.; Brand, A.; Holgate, S. T.; Kristiansen, L. V.; Lehrach, H.; Palotie, A.; Prainsack, B.: The future of technologies for personalised medicine. New Biotechnology 29 (6), pp. 625 - 633 (2012)

Jozefczuk, J.; Kashofer, K.; Ummanni, R.; Henjes, F.; Rehman, S.; Geenen, S.; Wruck, W.; Regenbrecht, C.; Daskalaki, A.; Wierling, C. K. et al.; Turano, P.; Bertini, I.; Korf, U.; Zatloukal, K.; Westerhoff, H. V.; Lehrach, H.; Adjaye, J.: A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells. Frontiers in Systems Biology 3 (3), 3:339 (2012)

Rubelt, F.; Sievert, V.; Knaust, F.; Diener, C.; Lim, T. S.; Skriner, K.; Klipp, E.; Reinhardt, R.; Lehrach, H.; Konthur, Z.: Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. PLoS One 7 (11), e49774 (2012)