Publications of Christoph K. Wierling

Wruck, W.; Kashofer, K.; Rehman, S.; Daskalaki, A.; Berg, D.; Gralka, E.; Jozefczuk, J.; Drews, K.; Pandey, V.; Regenbrecht, C. et al.; Wierling, C. K.; Turano, P.; Korf, U.; Zatloukal, K.; Lehrach, H.; Westerhoff, H. V.; Adjaye, J.: Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. Scientific Data 2, 150068 (2015)

Wierling, C. K.; Kessler, T.; Ogilvie, L. A.; Lange, B.; Yaspo, M.-L.; Lehrach, H.: Network and systems biology: essential steps in virtualising drug discovery and development. Drug Discovery Today: Technology 15, pp. 33 - 40 (2015)

Pandey, V.; Sultan, M.; Kashofer, K.; Ralser, M.; Amstislavskiy, V.; Starmann, J.; Osprian, I.; Grimm, C.; Hache, H.; Yaspo, M. L. et al.; Sultmann, H.; Trauner, M.; Denk, H.; Zatloukal, K.; Lehrach, H.; Wierling, C.: Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains. PLoS One 9 (10), e111006 (2014)

Röhr, C.; Kerick, M.; Fischer, A.; Kuehn, A.; Kashofer, K.; Timmermann, B.; Daskalaki, A.; Meinel, T.; Drichel, D.; Börno, S. et al.; Nowka, A.; Krobitsch, S.; McHardy, A. C.; Kratsch, C.; Becker, T.; Wunderlich, A.; Barmeyer, C.; Viertler, C.; Zatloukal, K.; Wierling, C.; Lehrach, H.; Schweiger, M.-R.: High-Throughput miRNA and mRNA Sequencing of Paired Colorectal Normal, Tumor and Metastasis Tissues and Bioinformatic Modeling of miRNA-1 Therapeutic Applications. PLoS One 8 (7), p. e67461 - e67461 (2013)

Götschel, F.; Berg, D.; Gruber, W.; Bender, C.; Eberl, M.; Friedel, M.; Sonntag, J.; Rungeler, E.; Hache, H.; Wierling, C. K. et al.; Nietfeld, W.; Lehrach, H.; Frischauf, A.; Schwartz-Albiez, R.; Aberger, F.; Korf, U.: Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1. PLoS One 8 (6), p. e65403 - e65403 (2013)

Kessler, T.; Hache, H.; Wierling, C.: Integrative analysis of cancer-related signaling pathways. Frontiers in Physiology 4, p. 4:124 - 4:124 (2013)

Wierling, C.; Kühn, A.; Hache, H.; Daskalaki, A.; Maschke-Dutz, E.; Peycheva, S.; Li, J.; Herwig, R.; Lehrach, H.: Prediction in the face of uncertainty: a Monte Carlo-based approach for systems biology of cancer treatment. Mutation Research-Genetic Toxixology and Environmental Mutagenesis 746 (2), pp. 163 - 170 (2012)

Eberl, M.; Klingler, S.; Mangelberger, D.; Loipetzberger, A.; Damhofer, H.; Zoidl, K.; Schnidar, H.; Hache, H.; Bauer, H. C.; Solca, F. et al.; Hauser-Kronberger, C.; Ermilov, A. N.; Verhaegen, M. E.; Bichakjian, C. K.; Dlugosz, A. A.; Nietfeld, W.; Sibilia, M.; Lehrach, H.; Wierling, C.; Aberger, F.: Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Molecular Medicine 4 (3), pp. 218 - 233 (2012)

Li, J.; Pandey, V.; Kessler, T.; Lehrach, H.; Wierling, C.: Modeling of miRNA and drug action in the EGFR signaling pathway. PLoS One 7 (1), e30140 (2012)

Jozefczuk, J.; Kashofer, K.; Ummanni, R.; Henjes, F.; Rehman, S.; Geenen, S.; Wruck, W.; Regenbrecht, C.; Daskalaki, A.; Wierling, C. K. et al.; Turano, P.; Bertini, I.; Korf, U.; Zatloukal, K.; Westerhoff, H. V.; Lehrach, H.; Adjaye, J.: A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells. Frontiers in Systems Biology 3 (3), 3:339 (2012)

Kamburov, A.; Pentchev, K.; Galicka, H.; Wierling, C.; Lehrach, H.; Herwig, R.: ConsensusPathDB: toward a more complete picture of cell biology. Nucleic Acids Research (London) 39 (Database issue), pp. D712 - D717 (2011)

Kowald, A.; Wierling, C.: Standards, tools, and databases for the analysis of yeast 'omics data. Methods in Molecular Biology 759, pp. 345 - 65 (2011)

Kühn, A.; Wierling, C.: Der virtuelle Patient - neue Wege in der Krebsforschung. Laborwelt 12 (6), pp. 19 - 20 (2011)

Stehr, H.; Jang, S. H.; Duarte, J. M.; Wierling, C.; Lehrach, H.; Lappe, M.; Lange, B. M.: The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors. Molecular Cancer 10, p. 54 (2011)

Hache, H.; Wierling, C.: Computerprogramme zur Modellierung genregulatorischer Netzwerke. Laborwelt 1, pp. 31 - 32 (2010)

Kühn, C.; Wierling, C.; Kühn, A.; Klipp, E.; Panopoulou, G.; Lehrach, H.; Poustka, A. J.: Monte-Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network. BMC Systems Biology 3, p. 83 - 83 (2009)

Nebrich, G.; Herrmann, M.; Hartl, D.; Diedrich, M.; Kreitler, T.; Wierling, C.; Klose, J.; Giavalisco, P.; Zabel, C.; Mao, L.: PROTEOMER: A workflow-optimized laboratory information management system for 2-D electrophoresis-centered proteomics. Proteomics 9 (7), pp. 1795 - 1808 (2009)

Hache, H.; Wierling, C.; Lehrach, H.; Herwig, R.: GeNGe: systematic generation of gene regulatory networks. Bioinformatics. Bioinformatics 25 (9), pp. 1205 - 1207 (2009)

Kamburov, A.; Wierling, C.; Lehrach, H.; Herwig, R.: ConsensusPathDB—a database for integrating human functional interaction networks. Nucleic Acids Research 37 (Database issue), pp. D623 - D628 (2008)

Wierling, C.; Herwig, R.; Lehrach, H.: Resources, standards and tools for systems biology. Briefings in Functional Genomics and Proteomics 6 (3), pp. 240 - 251 (2007)