Publications of T. Mielke

Ratje, A. H.; Loerke, J.; Mikolajka, A.; Brunner, M.; Hildebrand, P. W.; Starosta, A. L.; Donhofer, A.; Connell, S. R.; Fucini, P.; Mielke, T. et al.; Whitford, P. C.; Onuchic, J. N.; Yu, Y.; Sanbonmatsu, K. Y.; Hartmann, R. K.; Penczek, P. A.; Wilson, D. N.; Spahn, C. M.: Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature 468 (7324), pp. 713 - 716 (2010)

Armache, J. P.; Jarasch, A.; Anger, A. M.; Villa, E.; Becker, T.; Bhushan, S.; Jossinet, F.; Habeck, M.; Dindar, G.; Franckenberg, S. et al.; Marquez, V.; Mielke, T.; Thomm, M.; Berninghausen, O.; Beatrix, B.; Soding, J.; Westhof, E.; Wilson, D. N.; Beckmann, R.: Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Preceedings of the National Academy of Sciences USA 107 (46), pp. 19748 - 19753 (2010)

Armache, J. P.; Jarasch, A.; Anger, A. M.; Villa, E.; Becker, T.; Bhushan, S.; Jossinet, F.; Habeck, M.; Dindar, G.; Franckenberg, S. et al.; Marquez, V.; Mielke, T.; Thomm, M.; Berninghausen, O.; Beatrix, B.; Soding, J.; Westhof, E.; Wilson, D. N.; Beckmann, R.: Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome. Proceedings of the National Academy of Sciences USA 107 (46), pp. 19754 - 19759 (2010)

Bhushan, S.; Meyer, H.; Starosta, A. L.; Becker, T.; Mielke, T.; Berninghausen, O.; Sattler, M.; Wilson, D. N.; Beckmann, R.: Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. (2010)

Gartmann, M.; Blau, M.; Armache, J. P.; Mielke, T.; Topf, M.; Beckmann, R.: Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. The Journal of Biological Chemistry 285 (20), pp. 14848 - 14851 (2010)

Bhushan, S.; Gartmann, M.; Halic, M.; Armache, J. P.; Jarasch, A.; Mielke, T.; Berninghausen, O.; Wilson, D. N.; Beckmann, R.: alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel. Nature Structural & Molecular Biology 17 (3), pp. 313 - 317 (2010)

Liu, C.; Young, A. L.; Starling-Windhof, A.; Bracher, A.; Saschenbrecker, S.; Rao, B. V.; Rao, K. V.; Berninghausen, O.; Mielke, T.; Hartl, F. U. et al.; Beckmann, R.; Hayer-Hartl, M.: Coupled chaperone action in folding and assembly of hexadecameric Rubisco. Nature 463 (7278), pp. 197 - 202 (2010)

Becker, T.; Bhushan, S.; Jarasch, A.; Armache, J.-P.; Soledad, S.; Jossinet, F.; Gumbart, J.; Mielke, T.; Berninghausen, O.; Schulten, K. et al.; Westhof, E.; Gilmore, R.; Mandon, E. C.; Beckmann, R.: Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome. Science 326 (5958), pp. 1369 - 1373 (2009)

Jan-Christian Schuette, J.-C.; Murphy, F. V.; Kelley, A. C.; Weir, J. R.; Giesebrecht, J.; Connell, S. R.; Loerke, J.; Mielke, T.; Zhang, W.; Penczek, P. A. et al.; Ramakrishnan, V.; Spahn, C. M. T.: GTPase activation of elongation factor EF-Tu by the ribosome during decoding. The EMBO Journal 28 (6), pp. 755 - 765 (2009)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), pp. 910 - 915 (2008)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), pp. 910 - 915 (2008)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), pp. 910 - 915 (2008)

Chen, J. Z.; Sachse, C.; Xu, C.; Mielke, T.; Spahn, C. M. T.; Grigorieff, N.: A dose-rate effect in single-particle electron microscopy. Journal of Structural Biology 161 (1), pp. 92 - 100 (2008)

Kuhn, C.-D.; Geiger, S. R.; Baumli, S.; Gartmann, M.; Gerber, J.; Jennebach, S.; Mielke, T.; Tschochner, H.; Beckmann, R.; Cramer, P.: Functional architecture of RNA polymerase I. Cell 131 (7), pp. 1260 - 1272 (2007)

Connell, S. R.; Takemoto, C.; Wilson, D. N.; Wang, H.; Murayama, K.; Terada, T.; Shirouzu, M.; Rost, M.; Schüler, M.; Giesebrecht, J. et al.; Dabrowski, M.; Mielke, T.; Fucini, P.; Yokoyama, S.; Spahn, C. M. T.: Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Molecular Cell 25 (5), pp. 751 - 764 (2007)

Schüler, M.; Connell, S. R.; Lescoute, A.; Giesebrecht, J.; Dabrowski, M.; Schroeer, B.; Mielke, T.; Penczek, P. A.; Westhof, E.; Spahn, C. M. T.: Structure of the ribosome-bound cricket paralysis virus IRES RNA. Nature Structural & Molecular Biology 13 (12), pp. 1092 - 1096 (2006)

Halic, M.; Blau, M.; Becker, T.; Mielke, T.; Pool, M. R.; Wild, K.; Sinning, I.; Beckmann, R.: Following the signal sequence from ribosomal tunnel exit to signal recognition particle. Nature 444 (7118), pp. 507 - 511 (2006)

Andersen, C. B. F.; Becker, T.; Blau, M.; Anand, M.; Halic, M.; Balar, B.; Mielke, T.; Boesen, T.; Pedersen, J. S.; Spahn, C. M. T. et al.; Kinzy, T. G.; Andersen, G. R.; Beckmann, R.: Structure of eEF3 and the mechanism of transfer RNA release from the E-site. Nature 443 (7112), pp. 663 - 668 (2006)

Halic, M.; Gartmann, M.; Schlenker, O.; Mielke, T.; Pool, M. R.; Sinning, I.; Beckmann, R.: Signal recognition particle receptor exposes the ribosomal translocon binding site. Science 312 (5774), pp. 745 - 747 (2006)

Glaser, J.; Cova, G.; Fauler, B.; Prada-Medina, C. A.; Stanislas, V.; Phan, M. H. Q.; Schöpflin, R.; Aktas, Y.; Franke, M.; Andrey, G. et al.; Paliou, C.; Laupert, V.; Chan, W.-L.; Wittler, L.; Mielke, T.; Mundlos, S.: Enhancer adoption by an LTR retrotransposon generates viral-like particles causing developmental limb phenotypes. bioRxiv (2024)