Publications of Thorsten Mielke

Kornak, U.; Saha, N.; Keren, B.; Neumann, A.; Taylor Tavares, A. L.; Piard, J.; Kopp, J.; Rodrigues Alves, J. G.; de los Santos, M. R.; El Choubassi, N. et al.; Ehmke, N.; Jäger, M.; Spielmann, M.; Pantel, J. T.; Lejeune, E.; Fauler, B.; Mielke, T.; Hecht, J.; Meierhofer, D.; Strom, T. M.; Laugel, V.; Brice, A.; Mundlos, S.; Bertoli-Avella, A.; Bauer, P.; Heyd, F.; Boute, O.; Dupont, J.; Depienne, C.; Van Maldergem, L.; Fischer-Zirnsak, B.: Alternative splicing of BUD13 determines the severity of a developmental disorder with lipodystrophy and progeroid features. GENETICS IN MEDICINE 24 (9), pp. 1927 - 1940 (2022)

Hilal, T.; Killam, B. Y.; Grozdanović, M.; Dobosz-Bartoszek, M.; Loerke, J.; Bürger, J.; Mielke, T.; Copeland, P. R.; Simonović, M.; Spahn, C. M. T.: Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science 376, pp. 1338 - 1343 (2022)

Hochmair, J.; Exner, C.; Franck, M.; Dominguez-Baquero, A.; Diez, L.; Brognaro, H.; Kraushar, M.; Mielke, T.; Radbruch, H.; Kaniyappan, S. et al.; Falke, S.; Mandelkow, E.; Betzel, C.; Wegmann, S.: Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. The EMBO Journal 41 (11), e108882 (2022)

Heyder, N. A.; Kleinau, G.; Speck, D.; Schmidt, A.; Paisdzior, S.; Szczepek, M.; Bauer, B.; Koch, A.; Gallandi, M.; Kwiatkowski, D. et al.; Bürger, J.; Mielke, T.; Beck-Sickinger, A. G.; Hildebrand, P. W.; Spahn, C. M. T.; Hilger, D.; Schacherl, M.; Biebermann, H.; Hilal, T.; Kühnen, P.; Kobilka, B. K.; Scheerer, P.: Structures of active melanocortin-4 receptor−Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research, 0:1–14 (2021)

Banchenko, S.; Krupp, F.; Gotthold, C.; Bürger, J.; Graziadei, A.; O'Reilly, F. J.; Sinn, L.; Ruda, O.; Rappsilber, J.; Spahn , C. M. T. et al.; Mielke, T.; Taylor, I. A. ..; Schwefel, D.: Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. PLoS Pathogens 17 (8), e1009775 (2021)

Labarde, A.; Jakutyte, L.; Billaudeau, C.; Fauler, B.; López-Sanz, M.; Ponien, P.; Jacquet, E.; Mielke, T.; Ayora, S.; Carballido-López, R. et al.; Tavares, P.: Temporal compartmentalization of viral infection in bacterial cells. Proceedings of the National Academy of Sciences of the United States of America 118 (28), e2018297118 (2021)

Jaworski, P.; Zyla-Uklejewicz, D.; Nowaczyk-Cieszewska, M.; Donczew, R.; Mielke, T.; Weigel, C.; Zawilak-Pawlik, A.: Putative Cooperative ATP-DnaA Binding to Double-Stranded DnaA Box and Single-Stranded DnaA-Trio Motif upon Helicobacter pylori Replication Initiation Complex Assembly. International Journal of Molecular Sciences 22 (12), 6643 (2021)

Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Sampath Kumar, A.; Mattei, A. L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B. et al.; Giehr, P.; Buschow, R.; Galonska, C.; von Meyenn, F.; Pappalardi, M. B.; McCabe, M. T.; Wittler, L.; Giesecke-Thiel, C.; Mielke, T.; Meierhofer, D.; Timmermann, B.; Müller, F.-J.; Walter, J.; Meissner, A.: Dnmt1 has de novo activity targeted to transposable elements. Nature Structural and Molecular Biology 2021 (2021)

Pooryasin, A.; Maglione, M.; Schubert, M.; Matkovic-Rachid, T.; Hasheminasab, S.-M.; Pech, U.; Fiala, A.; Mielke, T.; Sigrist, S. J.: Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila. Nature Communications (12), 1932 (2021)

Nikolay, R.; Hilal, T.; Schmidt, S.; Qin, B.; Schwefel, D.; Vieira-Vieira, C. H.; Mielke, T.; Bürger, J.: Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Molecular Cell 81 (6), pp. 1200 - 1215 (2021)

Kraushar, M. L.; Krupp, F.; Harnett, D.; Turko, P.; Ambrozkiewicz, M. C.; Sprink, T.; Imami, K.; Günnigmann, M.; Zinnall, U.; Vieira-Vieira, C. H. et al.; Schaub, T.; Münster-Wandowski, A.; Bürger, J.; Borisova, E.; Yamamot, H.; Rasin, M.-R.; Ohlen, U.; Beule, D.; Mielke, T.; Tarabykin, V.; Landthaler, M.; Kramer, G.; Vida, I.; Selbach, M.; Spahn, C. M. T.: Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit. Molecular Cell 81 (2), e16, pp. 304 - 322 (2021)

Said, N.; Hilal, T.; Sunday, N. D.; Khatri, A.; Bürger, J.; Mielke, T.; Belogurov, G. A.; Loll, B.; Sen, R.; Artsimovitch, I. et al.; Wahl, M. C.: Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ. Science 371 (6524), eabd1673 (2021)

Xiao, Y.; Rabien, A.; Buschow, R.; Amstislavskiy, V.; Busch, J.; Kilic, E.; Villegas, S. L.; Timmermann, B.; Schütte, M.; Mielke, T. et al.; Yaspo, M.-L.; Jung, K.; Meierhofer, D.: Endocytosis-mediated replenishment of amino acids favors cancer cell proliferation and survival in chromophobe renal cell carcinoma. Cancer research: an official organ of the American Association for Cancer Research 80, pp. 5491 - 5501 (2020)

Radon, C.; Mittelstädt, G.; Duffus, B. R.; Bürger, J.; Hartmann, T.; Mielke, T.; Teutloff, C.; Leimkühler, S.; Wendler, P.: Cryo-EM structures reveal intricate Fe-S cluster arrangement and charging in Rhodobacter capsulatus formate dehydrogenase. Nature Communications 11, 1912 (2020)

Ignatiou, A.; Brasilès, S.; El Sadek Fadel, M.; Bürger, J.; Mielke, T.; Topf, M.; Tavares, P.; Orlova, E. V.: Structural transitions during the scaffolding-driven assembly of a viral capsid. Nature Communications 2019 (10), 10:4840 | (2019)

Brandt, R.; Sell, T.; Lüthen, M.; Uhlitz, F.; Klinger, B.; Riemer, P.; Giesecke-Thiel, C.; Schulze, S.; El-Shimy, I. A.; Kunkel, D. et al.; Fauler, B.; Mielke, T.; Mages, N.; Herrmann, B. G.; Sers, C.; Blüthgen, N.; Morkel, M.: Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nature Communications 10 (1), 2919 (2019)

Krupp, F.; Said, N.; Huang, Y.-H.; Loll, B.; Bürger, J.; Mielke, T.; Spahn, C. M.T.; Wahl, M. C.: Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor. Molecular Cell 74 (1), e5, pp. 143 - 157 (2019)

Flis, J.; Holm, M.; Rundlet, E. J.; Loerke, J.; Hilal, T.; Dabrowski, M.; Bürger, J.; Mielke, T.; Blanchard, S. C.; Spahn, C. M.T. et al.; Budkevich, T. V.: tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Reports 25 (10), e7, pp. 2676 - 2688 (2018)

Qureshi, B. M.; Behrmann, E.; Schöneberg, J.; Loerke, J.; Bürger, J.; Mielke, T.; Giesebrecht, J.; Noé, F.; Lamb, T. D.; Hofmann, K. P. et al.; Spahn, C. M. T.; Heck, M.: It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods. Open Biology 8 (8), 180075 (2018)

Jaworski, P.; Donczew, R.; Mielke, T.; Weigel, C.; Stingl, K.; Zawilak-Pawlik, A.: Structure and function of the Campylobacter jejuni chromosome replication origin. Frontiers in Microbiology 9, 9:1533 (2018)