Publications of Ralf Herwig

Bi, Y.; Lankenau, T. L.; Lienhard, M.; Herwig, R.: IsoTools 2.0: Software for Comprehensive Analysis of Long-read Transcriptome Sequencing Data. Journal of Molecular Biology, Article 169049 (2025)

Turewicz, M.; Skagen, C.; Hartwig, S.; Majda, S.; Thedinga, K.; Herwig, R.; Binsch , C.; Altenhofen, D.; Ouwens, D. M.; Förster, P. M. et al.; Wachtmeister, T.; Köhrer, K.; Stermann, T.; Chadt, A.; Lehr, S.; Marschall , T.; Thoresen, G. H.; Al-Hasani, H.: Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling. Nature Communications 16 (1), Article 1570 (2025)

Pacholewska, A.; Lienhard, M.; Brueggemann, M.; Haenel, H.; Bilalli, L.; Koenigs, A.; Hess, F.; Becker, K.; Koehrer, K.; Kaiser, J. F. et al.; Gohlke, H.; Gattermann, N.; Hallek, M.; Herling, C. D.; Koenig, J.; Grimm, C.; Herwig, R.; Zarnack, K.; Schweiger, M. R.: Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of SF3B1 mutations. Genome Research 34 (11), pp. 1832 - 1848 (2024)

Pardo-Palacios, F. J.; Wang, D.; Reese, F.; Diekhans, M.; Carbonell-Sala, S.; Williams, B.; Loveland, J. E.; De Maria, M.; Adams, M. S.; Balderrama-Gutierrez, G. et al.; Behera, A. K.; Gonzalez, J. M.; Hunt, T.; Lagarde, J.; Liang, C. E.; Li, H.; Jerryd Meade, M.; Moraga Amador, D. A.; Prjibelski, A. D.; Birol, I.; Bostan, H.; Brooks, A. M.; Hasan Celik, M.; Chen, Y.; Du, M. R. M.; Felton, C.; Goke, J.; Hafezqorani, S.; Herwig, R.; Kawaji, H.; Lee, J.; Liang Li, J.; Lienhard, M.; Mikheenko, A.; Mulligan, D.; Ming Nip, K.; Pertea, M.; Ritchie, M. E.; Sim, A. D.; Tang, A. D.; Kei Wan, Y.; Wang, C.; Wong, B. Y.; Yang, C.; Barnes, I.; Berry, A.; Capella, S.; Dhillon, N.; Fernandez-Gonzalez, J. M.; Ferrandez-Peral, L.; Garcia-Reyero, N.; Goetz, S.; Hernandez-Ferrer, C.; Kondratova, L.; Liu, T.; Martinez-Martin, A.; Menor, C.; Mestre-Tomas, J.; Mudge, J. M.; Panayotova, N. G.; Paniagua, A.; Repchevsky, D.; Rouchka, E.; Saint-John, B.; Sapena, E.; Sheynkman, L.; Laird Smith, M.; Suner, M. M.; Takahashi, H.; Youngworth, I. A.; Carninci, P.; Denslow, N. D.; Guigo, R.; Hunter, M. E.; Tilgner, H. U.; Wold, B. J.; Vollmers, C.; Frankish, A.; Fai Au, K.; Sheynkman, G. M.; Mortazavi, A.; Conesa, A.; Brooks, A. N.: Systematic assessment of long-read RNA-seq methods for transcript identification and quantification. Nature Methods 21 (7), pp. 1349 - 1363 (2024)

Springer, C.; Binsch, C.; Weide, D.; Toska, L.; Cremer, A. L.; Backes, H.; Scheel, A. K.; Espelage, L.; Kotzka, J.; Sill, S. et al.; Kurowski, A.; Daebin, K.; Karpinski, S.; Schnurr, T. M.; Hansen, T.; Hartwig, S.; Lehr, S.; Cames, S.; Brüning, J.; Lienhard, M.; Herwig, R.; Börno, S.; Timmermann, B.; Al-Hasani, H.; Chadt, A.: Depletion of TBC1D4 improves the metabolic exercise response by overcoming genetically induced peripheral insulin resistance. Diabetes 73 (7), pp. 1058 - 1071 (2024)

Campana , P. A.; Prasse , P.; Lienhard, M.; Thedinga, K.; Herwig, R.; Scheffer , T.: Cancer drug sensitivity estimation using modular deep Graph Neural Networks. NAR: Genomics and Bioinformatics 6 (2), Article lqae043 (2024)

Lienhard, M.; van den Beucken , T.; Timmermann, B.; Hochradel, M.; Boerno, S.; Caiment , F.; Vingron, M.; Herwig, R.: IsoTools: a flexible workflow for long-read transcriptome sequencing analysis. Bioinformatics 39 (6), btad364 (2023)

Bouabid, C.; Rabhi, S.; Thedinga, K.; Barel, G.; Tnani, H.; Rabhi , I.; Benkahla, A.; Herwig, R.; Guizani-Tabbane, L.: Host M-CSF induced gene expression drives changes in susceptible and resistant mice-derived BMdMs upon Leishmania major infection. Frontiers in immunology 14, 1111072 (2023)

Binsch, C.; Barbosa, D. M.; Hansen-Dille, G.; Hubert, M.; Hodge, S. M.; Kolasa, M.; Jeruschke, K.; Weiß, J.; Springer, C.; Gorressen, S. et al.; Fischer, J. W.; Lienhard, M.; Herwig, R.; Börno, S.; Timmermann, B.; Cremer, A. L.; Backes, H.; Chadt, A.; Al-Hasani, H.: Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion. Cardiovascular Diabetology 22 (1), 17 (2023)

Altenhofen, D.; Khuong, J. M.-A.; Kuhn, T.; Lebek, S.; Görigk, S.; Kaiser, K.; Binsch, C.; Griess, K.; Knebel, B.; Belgardt, B.-F. et al.; Cames, S.; Eickelschulte, S.; Stermann, T.; Rasche, A.; Herwig, R.; Weiss, J.; Vogel, H.; Schürmann, A.; Chadt, A.; Al-Hasani, H.: E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice. International Journal of Molecular Sciences 24 (1), 845 (2023)

Kuhn, T.; Kaiser, K.; Lebek, S.; Altenhofen, D.; Knebel, B.; Herwig, R.; Rasche, A.; Pelligra, A.; Görigk, S.; Khuong, J. M.-A. et al.; Vogel, H.; Schürmann, A.; Blüher, M.; Chadt, A.; Al-Hasani, H.: Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene. Human Molecular Genetics 31 (23), pp. 4019 - 4033 (2022)

Thomalla, D.; Beckmann, L.; Grimm , C.; Oliverio, M.; Meder, L.; Herling, C. D.; Nieper, P.; Feldmann, T.; Merkel, O.; Lorsy, E. et al.; da Palma Guerreiro , A.; von Jan, J.; Kisis, I.; Wasserburger, E.; Claasen, J.; Faitschuk-Meyer, E.; Altmüller, J.; Nürnberg, P.; Yang, T.-P.; Lienhard, M.; Herwig, R.; Kreuzer, K.-A.; Pallasch, C. P.; Buettner, R.; Schäfer, S. C.; Hartley, J.; Abken, H.; Peifer, M.; Kashkar, H.; Knittel, G.; Eichhorst , B.; Ullrich, R. T.; Herling, M.; Reinhardt, H. C.; Hallek, M.; Schweiger, M. R.; Frenzel, L. P.: Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies. Blood 140 (20), pp. 2113 - 2126 (2022)

Verheijen, M.; Sarkans, U.; Wolski, W.; Jennen, D.; Caiment , F.; Kleinjans, J.; HeCaToS , C.; Barel, G.; Boerno, S.; Herwig, R. et al.; Lienhard, M.; Timmermann, B. e. a.: Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds. Scientific Data 9 (1), 699 (2022)

Prasse, P.; Iversen, P.; Lienhard, M.; Thedinga, K.; Herwig, R.; Scheffer, T.: Pre-Training on In Vitro and Fine-Tuning on Patient-Derived Data Improves Deep Neural Networks for Anti-Cancer Drug-Sensitivity Prediction. Cancers / Molecular Diversity Preservation International (MDPI) 14 (16), 3950 (2022)

Thedinga, K.; Herwig, R.: Gradient tree boosting and network propagation for the identification of pan-cancer survival networks. STAR Protocols 3 (2), 101353 (2022)

Nguyen, N.; Lienhard, M.; Herwig, R.; Kleinjans, J.; Jennen, D.: Epirubicin Alters DNA Methylation Profiles Related to Cardiotoxicity. Frontiers in Bioscience-Landmark 27 (6), 173 (2022)

Prasse , P.; Iversen , P.; Lienhard, M.; Thedinga, K.; Bauer, C.; Herwig, R.; Scheffer, T.: Matching anticancer compounds and tumor cell lines by neural networks with ranking loss. NAR: genomics and bioinformatics 4 (1), lqab128 (2022)

Kamburov, A.; Herwig, R.: ConsensusPathDB 2022: molecular interactions update as a resource for network biology. Nucleic Acids Research 50 (D1), pp. D587 - D595 (2022)

Thedinga, K.; Herwig, R.: A gradient tree boosting and network propagation derived pan-cancer survival network of the tumor microenvironment. iScience 25 (1), 103617 (2021)

Pacholewska, A.; Grimm, C.; Herling, C. D.; Lienhard, M.; Königs, A.; Timmermann, B.; Altmüller, J.; Mücke, O.; Reinhardt, H. C.; Plass, C. et al.; Herwig, R.; Hallek, M.; Schweiger, M. R.: Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients. International Journal of Molecular Sciences 22 (17), 9337 (2021)