Current Position

Genome Institute of Singapore

60 Biopolis St, 138672 Singapore

www.a-star.edu.sg/gis/our-people/investigator-details.aspx?source=gis_fellows&user_id=160

Education

• 2006: Visiting student, University of Sheffield (UK)
• 2007: B.Sc. in Bioinformatics, Freie Universität Berlin (Germany)
• 2007 - 2012: PhD studies at the IMPRS-CBSC supervised by Prof. Dr. Martin Vingron

Work experience

• 2006-2007: Tutor at Freie Universität Berlin
• 2004-2007: Student assistant at the Charité
• 2004: Internship at Max Delbrück Center for Molecular Medicine (MDC)
• 2003: National Service (non-military option) at Charite Berlin, clinical cancer research

Dissertation

• Submitted May 2012
• Analysis of Long-Distance Gene Regulatory Elements

Scientific Interests

• Comparative Genomics
• Recurring motifs in non-coding DNA

Publications from time as IMPRS fellow

• H Hu et al. (2015)
  X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
  Mol Psychiatry, [epub ahead of print]
• J Göke, YS Chan, J Yan, M Vingron, HH Ng (2013)
  Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells.
  Mol Cell, 50 (6): 844-55
• YS Chan, J Göke, X Lu, N Venkatesan, B Feng, IH Su, HH Ng (2012)
  A PRC2 dependent repressive role of PRDM14 in human embryonic stem cells and iPSC reprogramming.
  Stem Cells, 31 (4): 682-92
• J Göke, MH Schulz, J Lasserre, M Vingron (2012)
  Estimation of pairwise sequence similarity of mammalian enhancers with word neighbourhood counts.
  Bioinformatics, 28 (5): 656-63
• J Göke et al. (2011)
  Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.
  PLoS Comput Biol., 7 (12): e1002304
• PJ McMurdie, SF Behrens, JA Müller, J Göke et al. (2009)
  Localized plasticity in the streamlined genomes of vinyl chloride respiring Dehalococcoides.
  PLoS Genet. 5 (11): e1000714
• K Kosta, I Sabroe, J Göke, RJ Nibbs, J Tsanakas, MK Whyte, MD Teare (2007)
  A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees.
  Am J Hum Genet., 81 (4): 808-12
• MD Teare, I Sabroe, J Goeke, M Whyte (2007)
  Family based association analysis of a copy number polymorphism in asthma families
  Genetic Epidemiology, 31 (5): 500
• J Gellermann, J Göke, R Figiel, M Weihrauch, CH Cho, V Budach, R Felix, P Wust (2007)
  Simulation of different applicator positions for treatment of a presacral tumour
  Int J Hyperthermia, 23 (1): 37-47
• Assembly and analysis of the genome of Dehalococcoides strain VS.
  Bachelor's thesis, Stanford University/ Freie Universität Berlin, 2007