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Journal Article (104)

  1. 81.
    Journal Article
    Spielmann, M.; Brancati, F.; Krawitz, P. M.; Robinson, P. N.; Ibrahim, D. M.; Franke, M.; Hecht, J.; Lohan, S.; Dathe, K.; Nardone, A. M. et al.; Ferrari, P.; Landi, A.; Wittler, L.; Timmermann, B.; Chan, D.; Mennen, U.; Klopocki, E.; Mundlos, S.: Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus. American Journal of Human Genetics 91 (4), pp. 629 - 635 (2012)
  2. 82.
    Journal Article
    Ralser, M.; Timmermann, B.: Genomanalyse von Modellorganismen: Saccharomyces cerevisiae. Biospektrum 18 (5), pp. 504 - 507 (2012)
  3. 83.
    Journal Article
    Ralser, M.; Kuhl, H.; Ralser, M.; Werber, M.; Lehrach, H.; Breitenbach, M.; Timmermann, B.: The Saccharomyces cerevisiae W303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt. Open Biology 2 (8) (2012)
  4. 84.
    Journal Article
    The 1000 Genomes Project Consortium; Sudbrak, R.; Albrecht, M.; Amstislavskiy, V.; Borodina, T. A.; Dahl, A.; Davydov, A.; Herwig, R.; Marquardt, P.; Mertes, F. et al.; Nietfeld, W.; Parkhomchuk, D.; Soldatov, A.; Timmermann, B.; Tolzmann, M.; Lehrach, H.: The 1000 Genomes Project: data management and community access. Nature methods 9 (5) (2012)
  5. 85.
    Journal Article
    MacArthur, D. G.; Balasubramanian, S.; Frankish, A.; 1000 Genomes Project, C.; Sudbrak, R.; Albrecht , M. W.; Amstislavskiy, V.; Borodina, T. A.; Dahl, A.; Davydov, A. et al.; Herwig, R.; Marquardt, P.; Mertes, F.; Nietfeld, W.; Parkhomchuk, D.; Soldatov, A.; Timmermann, B.; Tolzmann, M.; Lehrach, H.: A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes. Science 335 (6070), pp. 823 - 828 (2012)
  6. 86.
    Journal Article
    Goke, J.; Jung, M.; Behrens, S.; Chavez, L.; O'Keeffe, S.; Timmermann, B.; Lehrach, H.; Adjaye, J.; Vingron, M.: Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development. PLoS Comput Biol 7 (12), e1002304 (2011)
  7. 87.
    Journal Article
    Kerick, M.; Isau, M.; Timmermann, B.; Sultmann, H.; Herwig, R.; Krobitsch, S.; Schaefer, G.; Verdorfer, I.; Bartsch, G.; Klocker, H. et al.; Lehrach, H.; Schweiger, M. R.: Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics 4, p. 68 (2011)
  8. 88.
    Journal Article
    Kohlmann, A.; Klein, H. U.; Weissmann, S.; Bresolin, S.; Chaplin, T.; Cuppens, H.; Haschke-Becher, E.; Garicochea, B.; Grossmann, V.; Hanczaruk, B. et al.; Hebestreit, K.; Gabriel, C.; Iacobucci, I.; Jansen, J. H.; te Kronnie, G.; van de Locht, L.; Martinelli, G.; McGowan, K.; Schweiger, M. R.; Timmermann, B.; Vandenberghe, P.; Young, B. D.; Dugas, M.; Haferlach, T.: The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories. Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K 25 (12), pp. 1840 - 8 (2011)
  9. 89.
    Journal Article
    Prigione, A.; Lichtner, B.; Kuhl, H.; Struys, E. A.; Wamelink, M.; Lehrach, H.; Ralser, M.; Timmermann, B.; Adjaye, J.: Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming. Stem Cells 29 (9), pp. 1338 - 48 (2011)
  10. 90.
    Journal Article
    Schweiger, M. R.; Kerick, M.; Timmermann, B.; Isau, M.: The power of NGS technologies to delineate the genome organization in cancer: from mutations to structural variations and epigenetic alterations. Cancer Metastasis Reviews 30 (2), pp. 199 - 210 (2011)
  11. 91.
    Journal Article
    Timmermann, B.; Kerick, M.; Roehr, C.; Fischer, A.; Isau, M.; Boerno, S. T.; Wunderlich, A.; Barmeyer, C.; Seemann, P.; Koenig, J. et al.; Lappe, M.; Kuss, A. W.; Garshasbi, M.; Bertram, L.; Trappe, K.; Werber, M.; Herrmann, B. G.; Zatloukal, K.; Lehrach, H.; Schweiger, M. R.: Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS ONE 5 (12), p. e15661 - e15661 (2010)
  12. 92.
    Journal Article
    Kerick, M.; Timmermann, B.; Schweiger, M. R.: High-throughput sequencing of frozen and paraffin-embedded tumor and normal tissue. Pathologe 31 (suppl 2), pp. 255 - 257 (2010)
  13. 93.
    Journal Article
    Chavez, L.; Jozefczuk, J.; Grimm, C.; Dietrich, J.; Timmermann, B.; Lehrach, H.; Herwig, R.; Adjaye, J.: Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Research 20, pp. 1441 - 1450 (2010)
  14. 94.
    Journal Article
    Timmermann, B.; Jarolim, S.; Russmayer, H.; Kerick, M.; Michel, S.; Krüger, A.; Bluemlein, K.; Laun, P.; Grillari, J.; Lehrach, H. et al.; Breitenbach, M.; Ralser, M.: A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging. Aging (Albany NY) 2 (8), pp. 475 - 486 (2010)
  15. 95.
    Journal Article
    Dahl, A.; Mertes, F.; Timmermann, B.; Lehrach, H.: The application of massively parallel sequencing technologies in diagnostics. F1000 Biology Reports 2, p. 2:59 - 2:59 (2010)
  16. 96.
    Journal Article
    Weise, A.; Timmermann, B.; Grabherr, M.; Werber, M.; Heyn, P.; Kosyakova, N.; Liehr, T.; Neitzel, H.; Konrat, K.; Bommer, C. et al.; Dietrich, C.; Rajab, A.; Reinhardt, R.; Mundlos, S.; Lindner, T. H.; Hoffmann, K.: High-throughput sequencing of microdissected chromosomal regions. European Journal of Human Genetics, ejhg.2009.196, pp. 1 - 6 (2009)
  17. 97.
    Journal Article
    Schweiger, M. R.; Kerick, M.; Timmermann, B.; Albrecht, M. W.; Borodina, T.; Parkhomchuk, D.; Zatloukal, K.; Lehrach, H.: Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis. PLoS ONE 4 (5), p. e5548 - e5548 (2009)
  18. 98.
    Journal Article
    Ralser, M.; Nebel, A.; Kleindorp, R.; Krobitsch, S.; Lehrach, H.; Schreiber, S.; Reinhardt, R.; Timmermann, B.: Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. BMC Genetics 9, p. 9:38 - 9:38 (2008)
  19. 99.
    Journal Article
    Ralser, M.; Nebel, A.; Kleindorp, R.; Krobitsch, S.; Lehrach, H.; Schreiber, S.; Reinhardt, R.; Timmermann, B.: Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans. BMC Genetics 9, p. 9:38 - 9:38 (2008)
  20. 100.
    Journal Article
    Timmermann, B.; Sauer, S.; Dahl, A.; Reinhardt, R.: Genetische Variabilität des Menschen: Hochdurchsatz- Technologien und Datenanalyse. Laborwelt 5 (5), pp. 31 - 32 (2004)
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