Publications of Thorsten Mielke

Arumughan, A.; Roske, Y.; Barth, C.; Forero, L. L.; Bravo-Rodriguez, K.; Redel, A.; Kostova, S.; McShane, E.; Robert Opitz, R.; Faelber, K. et al.; Rau, K.; Mielke, T.; Daumke, O.; Selbach, M.; Sanchez-Garcia, E.; Rocks, O.; Daniela Panáková, D.; Heinemann, U.; Wanker, E. E.: Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nature Communications 7, 7:13047 (2016)

Jaworski, P.; Donczew, R.; Mielke, T.; Thiel, M.; Oldziej, S.; Weigel, C.; Zawilak-Pawlik, A.: Unique and Universal Features of Epsilonproteobacterial Origins of Chromosome Replication and DnaA-DnaA Box Interactions. Frontiers in Microbiology 7, 7:1555 (2016)

Gupta, V. K.; Pech, U.; Bhukel, A.; Fulterer, A.; Ender, A.; Mauermann, S. F.; Andlauer, T. F. M.; Antwi-Adjei, E.; Beuschel, C.; Thriene, K. et al.; Maglione, M.; Quentin, C.; Bushow, R.; Schwaerzel, M.; Mielke, T.; Dengjel, J.; Fiala, A.; Sigrist, S. J.: Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release. PLOS BIOLOGY 14 (9), e1002563 (2016)

Sprink, T.; Ramrath, D. J. F.; Yamamoto, H.; Yamamoto, K.; Loerke, J.; Ismer, J.; Hildebrand, P. W.; Scheerer, P.; Bürger, J.; Mielke, T. et al.; Spahn, C. M. T.: Structures of ribosome-bound initiation factor 2 reveal mechanism of subunit association. Science Advances 2 (3), e1501502 (2016)

Yamamoto, H.; Collier, M.; Loerke, J.; Ismer, J.; Schmidt, A.; Hilal, T.; Sprink, T.; Yamamoto, K.; Mielke, T.; Bürger, J. et al.; Shaikh, T. R.; Dabrowski, M.; Hildebrand, P. W.; Scheerer, P.; Spahn, C. M. T.: Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA. EMBO Journal 34 (24), pp. 3042 - 3058 (2015)

Behrmann, E.; Loerke, J.; Budkevich, T. .; Yamamoto, K.; Schmidt, A.; Penczek, P. .; Vos, M. .; Bürger, J.; Mielke, T.; Scheerer, P. et al.; Spahn, C. . T.: Structural Snapshots of Actively Translating Human Ribosomes. Cell 161 (4), pp. 845 - 857 (2015)

van der Sluis, E. O.; Bauerschmitt, H.; Becker, T.; Mielke, T.; Frauenfeld, J.; Berninghausen, O.; Neupert, W.; Herrmann, J. M.; Beckmann, R.: Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes. Genome biology and evolution 7 (5), pp. 1235 - 1251 (2015)

Muhs, M.; Hilal, T.; Mielke, T.; Skabkin, M. A.; Sanbonmatsu, K. Y.; Pestova, T. V.; Spahn, C. M. T.: Cryo-EM of ribosomal 80S complexes with termination factors reveals the translocated Cricket Paralysis Virus IRES. Molecular Cell 57 (3), pp. 422 - 432 (2015)

Röthlein, C.; Miettinen, M. S.; Borwankar, .; Bürger, J.; Mielke, T.; Kumke, M. U.; Ignatova, Z.: Architecture of polyglutamine-containing fibrils from time-resolved fluorescence decay. The Journal of Biological Chemistry 289 (39), pp. 26817 - 26828 (2014)

Yamamoto, H.; Unbehaun, A.; Loerke, J.; Behrmann, E.; Collier, M.; Bürger, J.; Mielke, T.; Spahn, C. M. T.: Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA. Nature Structural and Molecular Biology 21 (8), pp. 721 - 727 (2014)

Donczew, R.; Mielke, T.; Jaworski, P.; Zakrzewska-Czerwińska, J.; Zawilak-Pawlik, A.: Assembly of Helicobacter pylori initiation complex is determined by sequence-specific and topology-sensitive DnaA-oriC interactions. Journal of Molecular Biology (London) 426 (15), pp. 2769 - 2782 (2014)

Budkevich, T. V.; Giesebrecht, J.; Behrmann, E.; Loerke, J.; Ramrath, D. J.; Mielke, T.; Ismer, J.; Hildebrand, P. W.; Tung, C. S.; Nierhaus, K. H. et al.; Sanbonmatsu, K. Y.; Spahn, C. M.: Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement. Cell 158 (1), pp. 121 - 131 (2014)

Shah, C.; Hegde, B. G.; Morén, B.; Behrmann, E.; Mielke, T.; Moenke, G.; Spahn, C. M. T.; Lundmark, R.; Daumke, O.; Langen, R.: Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure 22 (3), pp. 409 - 420 (2014)

Becker, T.; Armache, J. P.; Jarasch, A.; Anger, A. M.; Villa, E.; Sieber, H.; Motaal, B. A.; Mielke, T.; Berninghausen, O.; Beckmann, R.: Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nature Structural & Molecular Biology 18 (6), pp. 715 - 20 (2011)

Bhushan, S.; Hoffmann, T.; Seidelt, B.; Frauenfeld, J.; Mielke, T.; Berninghausen, O.; Wilson, D. N.; Beckmann, R.: SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. PLoS Biology 9 (1), p. e1000581 (2011)

Budkevich, T.; Giesebrecht, J.; Altman, R. B.; Munro, J. B.; Mielke, T.; Nierhaus, K. H.; Blanchard, S. C.; Spahn, C. M.: Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell 44 (2), pp. 214 - 24 (2011)

Budkevich, T.; Giesebrecht, J.; Altman, R. B.; Munro, J. B.; Mielke, T.; Nierhaus, K. H.; Blanchard, S. C.; Spahn, C. M.: Structure and dynamics of the mammalian ribosomal pretranslocation complex. Molecular Cell 44 (2), pp. 214 - 24 (2011)

Czeko, E.; Seizl, M.; Augsberger, C.; Mielke, T.; Cramer, P.: Iwr1 directs RNA polymerase II nuclear import. Molecular Cell 42 (2), pp. 261 - 6 (2011)

Frauenfeld, J.; Gumbart, J.; Sluis, E. O.; Funes, S.; Gartmann, M.; Beatrix, B.; Mielke, T.; Berninghausen, O.; Becker, T.; Schulten, K. et al.; Beckmann, R.: Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Nature Structural & Molecular Biology 18 (5), pp. 614 - 21 (2011)

Muhs, M.; Yamamoto, H.; Ismer, J.; Takaku, H.; Nashimoto, M.; Uchiumi, T.; Nakashima, N.; Mielke, T.; Hildebrand, P. W.; Nierhaus, K. H. et al.; Spahn, C. M.: Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Res 39 (12), pp. 5264 - 75 (2011)