Max Planck Institute for Molecular Genetics

Gene transcription at multiple length scales

Hnisz Lab

We seek to understand how transcriptional programs are established during development, how their corruption leads to human pathologies, and how this knowledge can be used for therapeutic manipulation of human disease genes. We operate on the interphase of biology, chemistry and physics in a highly collaborative way to solve fundamental problems in gene regulation, currently using embryonic stem cells, cancer models, state-of-the art genetic and biochemical perturbation technologies, genome structure mapping and computational methods.

Zhang, Y.; Stöppelkamp, I.; Fernandez-Pernas, P.; Allram, M.; Charman, M.; Magalhães, A. P.; Piedavent-Salomon, M.; Sommer, G.; Sung, Y.-C.; Meyer, K. et al.; Grams, N.; Halko, E.; Dongre, S.; Meierhofer, D.; Malszycki, M.; Ilik, I. A.; Aktas, T.; Kraushar, M. L.; Vastenhouw, N.; Weitzman, M. D.; Grebien, F.; Niskanen, H.; Hnisz, D.: Probing condensate microenvironments with a micropeptide killswitch. Nature (2025)

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Sabari, B. R.; Hyman, A. A.; Hnisz, D.: Functional specificity in biomolecular condensates revealed by genetic complementation. Nature Reviews Genetics 26 (4), pp. 279 - 290 (2025)

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Naderi, J.; Magalhães, A. P.; Kibar, G.; Stik, G.; Zhang, Y.; Mackowiak, S.; Wieler, H. M.; Rossi, F.; Buschow, R.; Christou-Kent, M. et al.; Alcoverro-Bertran, M.; Graf, T.; Vingron, M.; Hnisz, D.: An activity-specificity trade-off encoded in human transcription factors. Nature Cell Biology 26 (8), pp. 1309 - 1321 (2024)

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Gene transcription at multiple length scales

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Barbara Vrancic

Gene transcription at multiple length scales

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