Publikationen von H. Lehrach

G. D. Poznik, Y. Xue, F. L. Mendez, T. F. Willems, A. Massaia, M. A. Wilson Sayres, Consortium The 1000 Genomes Projekt, H. Lehrach, R. Sudbrak, M. W. Albrecht, V. Amstislavskiy, T. A. Borodina, M. Lienhard, F. Mertes, M. Sultan, B. Timmermann, and M.-L. Yaspo, "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences," Nature Genetics 48 (6), 593-599 (2016).

Steven McGinn, David Bauer, Thomas Bretfort, Florian Mertes, Hans Lehrach, and Sascha Sauer, "New technologies for DNA analysis - a review of the READNA Project.," New biotechnology 33 (3), 311-330 (2016).

F. Broecker, C. Hardt, R. Herwig, B. Timmermann, M. Kerick, A. Wunderlich, M. R. Schweiger, L. Borsig, M. Heikenwalder, H. Lehrach, and K. Moelling, "Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line," The FEBS Journal 283 (9), 1669-1688 (2016).

C. Y. Lin, S. Erkek, Y. Tong, L. Yin, A. J. Federation, M. Zapatka, P. Haldipur, D. Kawauchi, T. Risch, H. J. Warnatz, B. C. Worst, B. Ju, B. A. Orr, R. Zeid, D. R. Polaski, M. Segura-Wang, S. M. Waszak, D. T. Jones, M. Kool, V. Hovestadt, I. Buchhalter, L. Sieber, P. Johann, L. Chavez, S. Groschel, M. Ryzhova, A. Korshunov, W. Chen, V. V. Chizhikov, K. J. Millen, V. Amstislavskiy, H. Lehrach, M. L. Yaspo, R. Eils, P. Lichter, J. O. Korbel, S. M. Pfister, J. E. Bradner, and P. A. Northcott, "Active medulloblastoma enhancers reveal subgroup-specific cellular origins," Nature 530 (7588), 57-62 (2016).

L. Chen, B. Ge, F. P. Casale, L. Vasquez, T. Kwan, D. Garrido-Martin, S. Watt, Y. Yan, K. Kundu, S. Ecker, A. Datta, D. Richardson, F. Burden, D. Mead, A. L. Mann, J. M. Fernandez, S. Rowlston, S. P. Wilder, S. Farrow, X. Shao, J. J. Lambourne, A. Redensek, C. A. Albers, V. Amstislavskiy, S. Ashford, K. Berentsen, L. Bomba, G. Bourque, D. Bujold, S. Busche, M. Caron, S. H. Chen, W. Cheung, O. Delaneau, E. T. Dermitzakis, H. Elding, I. Colgiu, F. O. Bagger, P. Flicek, E. Habibi, V. Iotchkova, E. Janssen-Megens, B. Kim, H. Lehrach, E. Lowy, A. Mandoli, F. Matarese, M. T. Maurano, J. A. Morris, V. Pancaldi, F. Pourfarzad, K. Rehnstrom, A. Rendon, T. Risch, N. Sharifi, M. M. Simon, M. Sultan, A. Valencia, K. Walter, S. Y. Wang, M. Frontini, S. E. Antonarakis, L. Clarke, M. L. Yaspo, S. Beck, R. Guigo, D. Rico, J. H. A. Martens, W. H. Ouwehand, T. W. Kuijpers, D. S. Paul, H. G. Stunnenberg, O. Stegle, K. Downes, T. Pastinen, and N. Soranzo, "Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells," Cell 167 (5), 1398-1414 (2016).

A. Perdomo-Sabogal, K. Nowick, I. Piccini, R. Sudbrak, H. Lehrach, M. L. Yaspo, H. J. Warnatz, and R. Querfurth, "Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa)," Molecular Biology and Evolution 33 (5), 1231-1244 (2016).

Wasco Wruck, Karl Kashofer, Samrina Rehman, Andriani Daskalaki, Daniela Berg, Ewa Gralka, Justyna Jozefczuk, Katharina Drews, Vikash Pandey, Christian Regenbrecht, Christoph K. Wierling, Paola Turano, Ulrike Korf, Kurt Zatloukal, Hans Lehrach, Hans V. Westerhoff, and James Adjaye, "Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes.," Scientific Data 2, 150068 (2015).

Stefan Kärst, Danny Arends, Sebastian Heise, Jan Trost, Marie-Laure Yaspo-Lehrach, Vyacheslav Amstislavskiy, Thomas Risch, Hans Lehrach, and Gudrun Brockmann, "Erratum," BMC Genomics 16, 1018-1018 (2015).

Florian Mertes, Björn Lichtner, Heiner Kuhl, Mirjam Blattner , Jörg Otte, Wasco Wruck, Bernd Timmermann, Hans Lehrach, and James Adjaye, "Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells," BMC Genomics 16, 16:925 (2015).

Stefan Kärst, Danny Arends, Sebastian Heise, Jan Trost, Marie-Laure Yaspo-Lehrach, Vyacheslav Amstislavskiy, Thomas Risch, and Hans Lehrach, "The direction of cross affects [corrected] obesity after puberty in male but not female offspring," BMC Genomics 16, 904 (2015).

Hans Lehrach, "Virtual Clinical Trials, an Essential Step in Increasing the Effectiveness of the Drug Development Process.," Public Health Genomics 18 (6), 366-371 (2015).

Peter H. Sudmant, Tobias Rausch, Eugene J. Gardner, Robert E. Handsaker, Alexej Abyzov, John Huddleston, The 1000 Genomes Project Consortium, Bernd Timmermann, Ralf Herwig, and Hans Lehrach, "An integrated map of structural variation in 2,504 human genomes," Nature 526 (7571), 75-81 (2015).

The 1000 Genome Project Consortium, Hans Lehrach, Vyacheslav Amstislavskiy, Matthias Lienhard, Florian Mertes, Marc Sultan, Bernd Timmermann, Marie-Laure Yaspo, and Ralf Herwig, "A global reference for human genetic variation," Nature 526 (7571), 68-74 (2015).

U. Fischer, M. Forster, A. Rinaldi, T. Risch, S. Sungalee, H. J. Warnatz, B. Bornhauser, M. Gombert, C. Kratsch, A. M. Stutz, M. Sultan, J. Tchinda, C. L. Worth, V. Amstislavskiy, N. Badarinarayan, A. Baruchel, T. Bartram, G. Basso, C. Canpolat, G. Cario, H. Cave, D. Dakaj, M. Delorenzi, M. P. Dobay, C. Eckert, E. Ellinghaus, S. Eugster, V. Frismantas, S. Ginzel, O. A. Haas, O. Heidenreich, G. Hemmrich-Stanisak, K. Hezaveh, J. I. Holl, S. Hornhardt, P. Husemann, P. Kachroo, C. P. Kratz, G. T. Kronnie, B. Marovca, F. Niggli, A. C. McHardy, A. V. Moorman, R. Panzer-Grumayer, B. S. Petersen, B. Raeder, M. Ralser, P. Rosenstiel, D. Schäfer, M. Schrappe, S. Schreiber, M. Schutte, B. Stade, R. Thiele, Nv Weid, A. Vora, M. Zaliova, L. Zhang, T. Zichner, M. Zimmermann, H. Lehrach, A. Borkhardt, J. P. Bourquin, A. Franke, J. O. Korbel, M. Stanulla, and M. L. Yaspo, "Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options," Nature Genetics 47 (9), 1020-1029 (2015).

Christoph K. Wierling, Thomas Kessler, Lesley A. Ogilvie, Bodo Lange, Marie-Laure Yaspo, and Hans Lehrach, "Network and systems biology: essential steps in virtualising drug discovery and development.," Drug Discovery Today: Technology 15, 33-40 (2015).

T. Redmer, Y. Welte, D. Behrens, I. Fichtner, D. Przybilla, W. Wruck, M. L. Yaspo, H. Lehrach, R. Schäfer, and C. R. Regenbrecht, "The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells," PLoS One 9 (5), e92596 (2015).

S. Kärst, D. Arends, S. Heise, J. Trost, M. L. Yaspo, V. Amstislavskiy, T. Risch, H. Lehrach, and G. A. Brockmann, "Erratum to: 'The direction of cross affects obesity after puberty in male but not female offspring'," BMC Genomics 16 (1), 16:1018 (2015).

Margret R. Hoehe, George M. Church, Hans Lehrach, Thomas Kroslak, Stefanie Palczewski, Katja Nowick, Sabrina Schulz, Eun-Kyung Suk, and Thomas Huebsch, "Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes," Nature Communications 5, 5:5569 (2014).

Thomas Willems, Melissa Gymrek, Gareth Highnam, Consortium The 1000 Genomes Project, Ralf Herwig, Hans Lehrach, Ralf Sudbrak, Bernd Timmermann, David Mittelman, and Yaniv Erlich, "The landscape of human STR variation," Genome Research 24 (11), 1894-1904 (2014).

V. Pandey, M. Sultan, K. Kashofer, M. Ralser, V. Amstislavskiy, J. Starmann, I. Osprian, C. Grimm, H. Hache, M. L. Yaspo, H. Sultmann, M. Trauner, H. Denk, K. Zatloukal, H. Lehrach, and C. Wierling, "Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains," PLoS One 9 (10), e111006 (2014).