Publikationen von Hans Lehrach

Steffen E. Künzel, Dominik P. Frentzel, Leonie T. M. Flesch, Vitus A. Knecht, Anne Rübsam, Felix Dreher, Moritz Schütte, Alexandre Dubrac, Bodo Lange, Marie-Laure Yaspo, Hans Lehrach, Antonia M. Joussen, and Oliver Zeitz, "AI-driven discovery of blood xenobiotic biomarkers in neovascular age-related macular degeneration using iterative random forests," Graefe's Archive for Clinical and Experimental Ophthalmology 262 (11), 3567-3575 (2024).

Steffen E. Künzel, Inga-Marie Pompös, Leonie T. M. Flesch, Dominik P. Frentzel, Vitus A. Knecht, Silvia Winkler, Sergej Skosyrski, Anne Rübsam, Felix Dreher, Norbert Kociok, Moritz Schütte, Alexandre Dubrac, Bodo Lange, Marie-Laure Yaspo, Hans Lehrach, Olaf Strauß, Antonia M. Joussen, and Oliver Zeitz, "Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice," Investigative Ophthalmology and Visual Science 65 (4), Article 5 (2024).

Martin Zacharias, Karl Kashofer, Philipp Wurm, Peter Regitnig, Moritz Schütte, Margit Neger, Sandra Ehmann, Leigh M. Marsh, Grazyna Kwapiszewska, Martina Loibner, Anna Birnhuber, Eva Leitner, Andrea Thüringer, Elke Winter, Stefan Sauer, Marion J. Pollheimer, Fotini R. Vagena, Carolin Lackner, Barbara Jelusic, Lesley Ogilvie, Marija Durdevic, Bernd Timmermann, Hans Lehrach, Kurt Zatloukal, and Gregor Gorkiewicz, "Host and microbiome features of secondary infections in lethal covid-19," iScience 25 (9), 104926 (2022).

Hans Lehrach, Jon Curtis, Bodo Lange, Lesley A. Ogilvie, Richard Gauss, Christoph Steininger, Erhard Scholz, and Matthias Kreck, "Proposal of a population wide genome-based testing for Covid-19," Scientific Reports 12, 5618 (2022).

Marius Geanta, Ankit Singh Tanwar, Hans Lehrach, Kapaettu Satyamoorthy, and Angela Brand, "Horizon Scanning: Rise of Planetary Health Genomics and Digital Twins for Pandemic Preparedness," OMICS: A Journal of Integrative Biology 26 (2), 93-100 (2021).

Marlen Keil, Theresia Conrad, Michael Becker, Ulrich Keilholz, Marie-Laure Yaspo, Hans Lehrach, Moritz Schütte, Johannes Haybaeck, and Jens Hoffmann, "Modeling of Personalized Treatments in Colon Cancer Based on Preclinical Genomic and Drug Sensitivity Data," Cancers 13 (23), 6018 (2021).

Rita Lampignano , Martin H.D. Neumann, Sabrina Weber, Vera Kloten, Andrei Herdean, Thorsten Voss, Daniel Groelz, Anna Babayan, Marco Tibbesma, Martin Schlumpberger, Francesca Chemi, Dominic G. Rothwell, Harriet Wikman, Jean-Pierre Galizzi, Inger Riise Bergheim, Hege Russnes, Benedetta Mussolin, Serena Bonin, Christine Voigt, Hanny Musa, Pamela Pinzani, Evi Lianidou, Ged Brady, Michael R. Speicher, Klaus Pantel, Fay Betsou, Ed Schuuring, Mikael Kubista, Wim Ammerlaan, Markus Sprenger-Haussels, Thomas Schlange, Ellen Heitzer, Hans Lehrach, and Marie-Laure Yaspo, "Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows," Clinical Chemistry: International Journal of Molecular Diagnostics and Laboratory Medicine 66 (1), 149-160 (2020).

H. J. Abu‑Toamih Atamni, G. Kontogianni, I. Binenbaum, R. Mott, H. Himmelbauer, H. Lehrach, A. Chatziioannou, and Fuad A. Iraqi, "Hepatic gene expression variations in response to high-fat diet-induced impaired glucose tolerance using RNAseq analysis in collaborative cross mouse population," Mammalian Genome 30 (9-10), 260-275 (2019).

Joanna Segal, Michael Mülleder, Antje Krüger, Thure Adler, Manuela Scholze-Wittler, Lore Becker, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Birgit Rathkolb, Jan Rozman, Ildiko Racz, Ralf Fischer, Dirk H. Busch, Frauke Neff, Martin Klingenspor, Thomas Klopstock, Nana-Maria Grüning, Steve Michel, Beata Lukaszewska-McGreal, Ingo Voigt, Ludger Hartmann, Bernd Timmermann, Hans Lehrach, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Helmut Fuchs, Martin H. de Angelis, Heinrich Schrewe, Mariia Yuneva, and Markus Ralser, "Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency," Journal of Inherited Metabolic Disease 22 (5), 839-849 (2019).

Sophia Schade, Lesley A. Ogilvie, Thomas Kessler, Moritz Schütte, Christoph Wierling, Bodo M. Lange, Hans Lehrach, and Marie-Laure Yaspo, "A data- and model-driven approach for cancer treatment," Der Onkologe 25 (Suppl. 2), S132-S137 (2019).

Sophia Schade, Lesley A. Ogilvie, Thomas Kessler, Moritz Schütte, Christoph Wierling, Bodo M. Lange, Hans Lehrach, and Marie-Laure Yaspo, "Ein daten- und modellgesteuerter Ansatz zur Behandlung maligner Tumoren," Der Onkologe 25 (Suppl. 1), S109-S115 (2019).

C. F. Ciusdel, S. Coman, Cr. Boldisor, T. Kessler, A. Muradyan, A. Kovachev, H. Lehrach, C. Wierling, and L. M. Itu, "Effect of Linearization in a WNT Signaling Model," Computational and Mathematical Methods in Medicine , 8461820 (2019).

Wei Gu, Reha Yildirimman, Emmanuel Van der Stuyft, Denny Verbeeck, Sascha Herzinger, Venkata Satagopam, Adriano Barbosa-Silva, Reinhard Schneider, Bodo Lange, Hans Lehrach, Yike Guo, David Henderson, and Anthony Rowe, "Data and knowledge management in translational research: implementation of the eTRIKS platform for the IMI OncoTrack consortium," BMC Bioinformatics 20 (1), 164 (2019).

Sabrina Grasse, Matthias Lienhard, Steffen Frese, Martin Kerick, Anne Steinbach, Christina Grimm, Michelle Hussong, Jana Rolff, Michael Becker, Felix Dreher, Uwe Schirmer, Stefan T. Boerno, Anna Ramisch, Gunda Leschber, Bernd Timmermann, Christian Grohé, Heike Lüders, Martin Vingron, Iduna Fichtner, Sebastian Klein, Margarete Odenthal, Reinhard Büttner, Hans Lehrach, Holger Sültmann, Ralf Herwig, and Ruth M. Schweiger, "Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance," Genome Medicine 10 (1), 10:55 (2018).

Praneeth Reddy Devullapally, Jörg Bürger, Thorsten Mielke, Zoltán Konthur, Hans Lehrach, Marie-Laure Yaspo, Jörn Glökler, and Hans-Jörg Warnatz, "Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes," Genome Medicine 10, 10:34 (2018).

J. L. Regan, D. Schumacher, S. Staudte, A. Steffen, J. Haybaeck, U. Keilholz, C. Schweiger, N. Golob-Schwarzl, D. Mumberg, D. Henderson, H. Lehrach, C. R. A. Regenbrecht, R. Schafer, and M. Lange, "Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells," Cell Reports 21 (10), 2813-2828 (2017).

N. Golob-Schwarzl, C. Schweiger, C. Koller, S. Krassnig, M. Gogg-Kamerer, N. Gantenbein, A. M. Toeglhofer, C. Wodlej, H. Bergler, B. Pertschy, S. Uranitsch, M. Holter, A. El-Heliebi, J. Fuchs, A. Punschart, P. Stiegler, M. Keil, J. Hoffmann, D. Henderson, H. Lehrach, C. Reinhard, C. Regenbrecht, R. Schicho, P. Fickert, S. Lax, and J. Haybaeck, "Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6," Oncotarget 8 (60), 101224-101243 (2017).

L. A. Ogilvie, A. Kovachev, C. Wierling, B. M. H. Lange, and H. Lehrach, "Models of Models: A Translational Route for Cancer Treatment and Drug Development," Frontiers in Oncology 7, 7:219 (2017).

M. Schütte, L. A. Ogilvie, D. T. Rieke, B. M. H. Lange, M. L. Yaspo, and H. Lehrach, "Cancer Precision Medicine: Why More Is More and DNA Is Not Enough," Public Health Genomics 20 (2), 70-80 (2017).

M. Schütte, T. Risch, N. Abdavi Azar, K. Boehnke, D. Schumacher, M. Keil, R. Yildiriman, C. Jandrasits, T. Borodina, V. Amstislavskiy, C. L. Worth, C. Schweiger, S. Liebs, M. Lange, H. J. Warnatz, L. M. Butcher, J. E. Barrett, M. Sultan, C. Wierling, N. Golob-Schwarzl, S. Lax, S. Uranitsch, M. Becker, Y. Welte, J. L. Regan, M. Silvestrov, I. Kehler, A. Fusi, T. Kessler, R. Herwig, U. Landegren, D. Wienke, M. Nilsson, J. A. Velasco, P. Garin-Chesa, C. Reinhard, S. Beck, R. Schafer, C. R. Regenbrecht, D. Henderson, B. Lange, J. Haybaeck, U. Keilholz, J. Hoffmann, H. Lehrach, and M. L. Yaspo, "Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors," Nature Communications 8, 8:14262 (2017).