Foto: David Ausserhofer
Dr. Sara Hetzel
Kretzmer Lab
Sara hat ihren Bachelor- und Masterabschluss in Bioinformatik an der Freien Universität Berlin gemacht. Die Forschung für ihre Masterarbeit führte sie als Austauschstudentin an der CSIRO in Sydney durch, wo sie die Off-Target-Effekte von CRISPR-Cas9 untersuchte. Nach ihrer Rückkehr kam Sara als Doktorandin in Alex' Labor und untersuchte die Rolle der DNA-Methylierung bei menschlichem Krebs und passenden Mausmodellen.
Veröffentlichungen
Zeitschriftenartikel (11)
1.
Zeitschriftenartikel
Julia Batki, Sara Hetzel, Dennis Schifferl, Adriano Bolondi, Maria Walther, Lars Wittler, Stefanie Grosswendt, Bernhard G. Herrmann, and Alexander Meissner, "Extraembryonic gut endoderm cells undergo programmed cell death during development," Nature Cell Biology 26 (6), 868-877 (2024).
2.
Zeitschriftenartikel
Hannes Hauswedell , Sara Hetzel, Simon G. Gottlieb , Helene Kretzmer, Alexander Meissner, and Knut Reinert, "Lambda3: homology search for protein, nucleotide, and bisulfite-converted sequences," Bioinformatics 40 (3), Article btae097 (2024).
3.
Zeitschriftenartikel
Marius-Konstantin Klever, Eric Sträng , Sara Hetzel, Julius Jungnitsch, Anna Dolnik, Robert Schöpflin, Jens-Florian Schrezenmeier, Felix Schick, Olga Blau, Jörg Westermann, Frank G . Rücker , Zuyao Xia, Konstanze Döhner, Hubert Schrezenmeier, Malte Spielmann, Alexander Meissner, Uirá Souto Melo, Stefan Mundlos, and Lars Bullinger, "AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology," Blood Advances 7 (21), 6520-6531 (2023).
4.
Zeitschriftenartikel
Raha Weigert, Sara Hetzel, Nina Bailly, Chuck Haggerty, Ibrahim A. Ilik, Philip Yuk Kwong Yung, Carmen Navarro, Adriano Bolondi, Abhishek Sampath Kumar, Chiara Anania, Björn Brändl, David Meierhofer, Darío G. Lupiáñez, Franz-Josef Müller, Tugce Aktas, Simon J. Elsässer, Helene Kretzmer, Zachary D. Smith, and Alexander Meissner, "Dynamic antagonism between key repressive pathways maintains the placental epigenome," Nature Cell Biology 25 (4), 579-591 (2023).
5.
Zeitschriftenartikel
Alessa Ringel, Quentin Szabo, Andrea M. Chiariello, Konrad Chudzik, Robert Schöpflin, Patricia Rothe, Alexandra L. Mattei, Tobias Zehnder, Dermot Harnett, Verena Laupert, Simona Bianco, Sara Hetzel, Juliane Glaser, Mai H. Q. Phan, Magdalena Schindler, Daniel M. Ibrahim, Christina Paliou, Andrea Esposito, César A. Prada-Medina, Stefan A. Haas, Peter Giere, Martin Vingron, Lars Wittler, Alexander Meissner, Mario Nicodemi, Giacomo Cavalli, Frédéric Bantignies, Stefan Mundlos, and Michael I. Robson, "Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes," Cell 185 (20), 3689-3704 (2022).
6.
Zeitschriftenartikel
Vahid Asimi, Abhishek Sampath Kumar, Henri Niskanen, Christina Riemenschneider, Sara Hetzel, Julian Naderi, Nina Fasching, Niko Popitsch, Manyu Du, Helene Kretzmer, Zachary D. Smith, Raha Weigert, Maria Walther, Sainath Mamde, David Meierhofer, Lars Wittler, Rene Buschow, Bernd Timmermann, Ibrahim I. Cisse, Stefan L. Ameres, Alexander Meissner, and Denes Hnisz, "Hijacking of transcriptional condensates by endogenous retroviruses," Nature Genetics 54, 1238-1247 (2022).
7.
Zeitschriftenartikel
Sara Hetzel, Alexandra L. Mattei, Helene Kretzmer, Chunxu Qu, Xiang Chen, Yiping Fan, Gang Wu, Kathryn G. Roberts, Selina Luger, Mark Litzow, Jacob Rowe, Elisabeth Paietta, Wendy Stock, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Charles G. Mullighan, and Alexander Meissner, "Acute lymphoblastic leukemia displays a distinct highly methylated genome," Nature Cancer 3 (6), 768-782 (2022).
8.
Zeitschriftenartikel
Sara Hetzel, Pay Gießelmann, Knut Reinert, Alexander Meissner, and Helene Kretzmer, "RLM: Fast and simplified extraction of Read-Level Methylation metrics from bisulfite sequencing data," Bioinformatics 37 (21), 3934-3935 (2021).
9.
Zeitschriftenartikel
Marlies P. Rossmann, Karen Hoi, Victoria Chan, Brian J. Abraham, Song Yang, James Mullahoo, Malvina Papanastasiou, Ying Wang, Ilaria Elia, Julie R. Perlin, Elliott J. Hagedorn, Sara Hetzel, Raha Weigert, Sejal Vyas, Partha P. Nag, Lucas B. Sullivan, Curtis R. Warren, Bilguujin Dorjsuren, Eugenia Custo Greig, Isaac Adatto, Chad A. Cowan, Stuart L. Schreiber, Richard A. Young, Alexander Meissner, Marcia C. Haigis, Siegfried Hekimi, Steven A. Carr, and Leonard I. Zon, "Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis," Science 372 (6543), 716-721 (2021).
10.
Zeitschriftenartikel
Stefanie Grosswendt, Helene Kretzmer, Zachary D. Smith, Abhishek Sampath Kumar, Sara Hetzel, Lars Wittler, Sven Klages, Bernd Timmermann, Shankar Mukherji, and Alexander Meissner, "Epigenetic regulator function through mouse gastrulation," Nature 584, 102-108 (2020).