Max Planck Publications of Hnisz Lab

The following publications were published exclusively under the affiliation of the Max Planck Society. For publications by the principal investigator outside of the Max Planck Society, see the links on the lower left.

Journal Article (13)

Journal Article

Naderi, J.; Magalhães, A. P.; Kibar, G.; Stik, G.; Zhang, Y.; Mackowiak, S.; Wieler, H. M.; Rossi, F.; Buschow, R.; Christou-Kent, M. et al.; Alcoverro-Bertran, M.; Graf, T.; Vingron, M.; Hnisz, D.: An activity-specificity trade-off encoded in human transcription factors. Nature Cell Biology 26 (8), pp. 1309 - 1321 (2024)

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Journal Article

Basu, S.; Martínez-Cristóbal, P.; Frigolé-Vivas, M.; Pesarrodona, M.; Lewis, M.; Szulc, E.; Bañuelos, C. A.; Sánchez-Zarzalejo, C.; Bielskutė, S.; Zhu, J. et al.; Pombo-García, K.; Garcia-Cabau, C.; Zodi, L.; Dockx, H.; Smak, J.; Kaur, H.; Batlle, C.; Mateos, B.; Biesaga, M.; Escobedo, A.; Bardia, L.; Verdaguer, X.; Ruffoni, A.; Mawji, N. R.; Wang, J.; Obst, J. K.; Tam, T.; Brun-Heath, I.; Ventura, S.; Meierhofer, D.; García, J.; Robustelli, P.; Stracker, T. H.; Sadar, M. D.; Riera, A.; Hnisz, D.; Salvatella, X.: Rational optimization of a transcription factor activation domain inhibitor. Nature Structural & Molecular Biology 30 (12), pp. 1958 - 1969 (2023)

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Bressin, A.; Jasnovidova, O.; Arnold, M.; Altendorfer, E.; Trajkovski , F.; Kratz, T. A.; Handzlik, J. E.; Hnisz, D.; Mayer, A.: High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription. Nature Communications 14 (1), Article 4971 (2023)

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Journal Article

Christou-Kent, M.; Cuartero, S.; Garcia-Cabau, C.; Ruehle, J.; Naderi, J.; Erber, J.; Neguembor, M. V.; Plana-Carmona, M.; Alcoverro-Bertran, M.; De Andres-Aguayo, L. et al.; Klonizakis, A.; Julià-Vilella, E.; Lynch, C.; Serrano, M.; Hnisz, D.; Salvatella, X.; Graf, T.; Stik, G.: CEBPA phase separation links transcriptional activity and 3D chromatin hubs. Cell Reports 42 (8), 112897 (2023)

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Journal Article

Dejosez, M.; Dall’Agnese, A.; Ramamoorthy, M.; Platt, J.; Yin, X.; Hogan, M.; Brosh, R.; Weintraub, A. S.; Hnisz, D.; Abraham, B. J. et al.; Young, R. A.; Zwaka, T. P.: Regulatory architecture of housekeeping genes is driven by promoter assemblies. Cell Reports 42 (5), 112505 (2023)

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Journal Article

Mensah, M. A.; Niskanen, H.; Magalhães, A. P.; Basu, S.; Kircher, M.; Sczakiel, H. L.; Reiter, A. M. V.; Elsner, J.; Meinecke, P.; Biskup, S. et al.; Chung, B. H. Y.; Dombrowsky, G.; Eckmann-Scholz, C.; Hitz, M. P.; Hoischen, A.; Holterhus, P.-M.; Hülsemann, W.; Kahrizi, K.; Kalscheuer, V. M.; Kan, A.; Krumbiegel, M.; Kurth, I.; Leubner, J.; Longardt, A. C.; Moritz, J. D.; Najmabadi, H.; Skipalova, K.; Snijders Blok, L.; Tzschach, A.; Wiedersberg, E.; Zenker, M.; Garcia-Cabau, C.; Buschow, R.; Salvatella, X.; Kraushar, M. L.; Mundlos, S.; Caliebe, A.; Spielmann, M.; Horn, D.; Hnisz, D.: Aberrant phase separation and nucleolar dysfunction in rare genetic diseases. Nature 614 (7948), pp. 564 - 571 (2023)

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Journal Article

Landshammer, A.; Bolondi, A.; Kretzmer, H.; Much, C.; Buschow, R.; Rose, A.; Wu, H.-J.; Mackowiak, S. D.; Braendl, B.; Gießelmann, P. et al.; Tornisiello, R.; Mohan Parsi, K.; Huey, J.; Mielke, T.; Meierhofer, D.; Maehr, R.; Hnisz, D.; Michor, F.; Rinn, J. L.; Meissner, A.: T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation. eLife 12, Article e83077 (2023)

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Asimi, V.; Sampath Kumar, A.; Niskanen, H.; Riemenschneider, C.; Hetzel, S.; Naderi, J.; Fasching, N.; Popitsch, N.; Du, M.; Kretzmer, H. et al.; Smith, Z. D.; Weigert, R.; Walther, M.; Mamde, S.; Meierhofer, D.; Wittler, L.; Buschow, R.; Timmermann, B.; Cisse, I. I.; Ameres, S. L.; Meissner, A.; Hnisz, D.: Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics 54 (8), pp. 1238 - 1247 (2022)

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Adane, B.; Alexe, G.; Seong, B. K. A.; Lu, D.; Hwang, E. E.; Hnisz, D.; Lareau, C. A.; Ross, L.; Lin, S.; Dela Cruz, F. S. et al.; Richardson, M.; Weintraub, A. S.; Wang, S.; Balboni Iniguez, A.; Dharia, N. V.; Saur Conway, A.; Robichaud, A. L.; Tanenbaum, B.; Krill-Burger, J. M.; Vazquez, F.; Schenone, M.; Berman, J. N.; Kung, A. L.; Carr, S. A.; Aryee, M. J.; Young, R. A.; Crompton, B. D.; Stegmaier, K.: STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Cancer Cell 39 (6), pp. 827 - 844 (2021)

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ZIP

Journal Article

Jaeger, M. G.; Schwalb, B.; Mackowiak, S. D.; Velychko, T.; Hanzl, A.; Imrichova, H.; Brand, M.; Agerer, B.; Chorn, S.; Nabet, B. et al.; Ferguson, F. M.; Müller, A. C.; Bergthaler, A.; Gray, N. S.; Bradner, J. E.; Bock, C.; Hnisz, D.; Cramer, P.; Winter, G. E.: Selective Mediator dependence of cell-type-specifying transcription. Nature Genetics 52 (7), pp. 719 - 727 (2020)

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Journal Article

Basu, S.; Mackowiak, S.; Niskanen, H.; Knezevic, D.; Asimi, V.; Grosswendt, S.; Geertsema, H.; Ali, S.; Jerković, I.; Ewers, H. et al.; Mundlos, S.; Meissner, A.; Ibrahim, D. M.; Hnisz, D.: Unblending of Transcriptional Condensates in Human Repeat Expansion Disease. Cell 181 (5), pp. 1062 - 1079 (2020)

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Journal Article

Sabari, B. R.; Dall’Agnese, A.; Boija, A.; Klein, I. A.; Coffey, E. L.; Shrinivas, K.; Abraham, B. J.; Hannett, N. M.; Zamudio, A. V.; Manteiga, J. C. et al.; Li, C. H.; Guo, Y. E.; Day, D. S.; Schuijers, J.; Vasile, E.; Malik, S.; Hnisz, D.; Lee, T. I.; Cisse, I. I.; Roeder, R. G.; Sharp, P. A.; Chakraborty, A. K.; Young, R. A.: Coactivator condensation at super-enhancers links phase separation and gene control. Science (6400), eaar3958 (2018)

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Journal Article

Schuijers, J.; Manteiga, J. C.; Weintraub, A. S.; Day, D. S.; Zamudio, A. V.; Hnisz, D.; Lee, T. I.; Young, R. A.: Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism. Cell Reports 23 (2), pp. 349 - 360 (2018)

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Thesis - PhD (3)

Thesis - PhD

Naderi, J.: The dispersion of aromatic residues in TF IDRs controls a molecular trade-off between activity and specificity. Dissertation (2024)

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Thesis - PhD

Basu, S.: Genetic and chemical hydrophobic modification of transcription factor condensates in human disease. Dissertation (2023)

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Thesis - PhD

Asimi, V.: Roles of endogenous retroviruses in transcriptional condensates. Dissertation (2023)

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Review Article (1)

Review Article

Sabari, B. R.; Hyman, A. A.; Hnisz, D.: Functional specificity in biomolecular condensates revealed by genetic complementation. Nature Reviews Genetics 26 (4), pp. 279 - 290 (2025)

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Preprint (1)

Preprint

Basu, S.; Martínez-Cristóbal, P.; Pesarrodona, M.; Frigolé-Vivas, M.; Szulc, E.; Lewis, M.; Bañuelos, C. A.; Sánchez-Zarzalejo, C.; Bielskutė, S.; Zhu, J. et al.; Garcia-Cabau, C.; Batlle, C.; Mateos, B.; Biesaga, M.; Escobedo, A.; Bardia, L.; Verdaguer, X.; Ruffoni, A.; Mawji, N. R.; Wang, J.; Tam, T.; Brun-Heath, I.; Ventura, S.; Meierhofer, D.; García, J.; Robustelli, P.; Stracker, T. H.; Sadar, M. D.; Riera, A.; Hnisz, D.; Salvatella, X.: Androgen receptor condensates as drug targets. bioRxiv (2022)

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pre-print