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Publication - 02.02.2024

Publication - 02.02.2024

Edda wrote a spotlight article about recent work from the Cremins lab. They found that DNA repeat expansions in Fragile X syndrome result in large heterochromatin domains that interact in trans.
New team member - 15.01.2024

New team member - 15.01.2024

Vivi Feng joins our team as a PhD candidate. Welcome Vivi!
JJF/Midjourney

Edda joins funding board - 28.11.2023

Congratulations to Edda, who got elected into the review board of the main German research funding agency, Deutsche Forschungsgemeinschaft (DFG), or in English: German Research Foundation.
The review board helps to assess research proposals and shape funding policies in the subject “General Genetics and Functional Genomics”.
 
Attending conferences - 27.09.2023

Attending conferences - 27.09.2023

Edda will participate at two upcoming conferences and speak about our work. Please reach out when you are there!
New team members - 27.09.2023

New team members - 27.09.2023

Diana Mojica and Ingrid Pelaez Conde are starting their PhD project and Heleen Mallie joins us for an internship. Welcome to the team!
Publication - 27.09.2023

Publication - 27.09.2023

Read our work: we used serial perturbations with quantitative mathematical modelling to discover the signaling pathways that regulate differences between stem cells with two (female) and one X-chromosome.
Attending conferences - 24.07.2023

Attending conferences - 24.07.2023

Till presents his work on how two different developmental signals are integrated by TFs and cis-regulatory DNA, at the Xist locus. Meet Till here:
X-chromosome inactivation meeting starts - 19.06.2023

X-chromosome inactivation meeting starts - 19.06.2023

The lab is excited about the X-chromosome inactivation meeting, 19-22 June 2023, in Berlin. Edda is co-organizer; the whole lab is assisting, and we are all looking forward to meeting the community!
  • Meeting website
  • Gemma speaks on Tuesday, Edda on Wednesday, and we present posters: Alex (II-62), Elodie (II-46), Nelly (I-39), and Till (II-70)
generated using Midjourney

Publication - 06.06.2023

CasTuner - our tool to tune endogenous gene expression:
Out in a peer-reviewed version, tested on additional targets, in human cells and on physiological phenotypes.
Attending conference  - 22.05.2023

Attending conference  - 22.05.2023

Reach out to Gemma Noviello at the
EMBO workshop: Systems biology: Linking chromatin and epigenetics to disease and development, 25 May– 28 May 2023 in Alexandroupoli, Greece.
Gemma will present her work on CasTuner and non-linear dose-responses in X-inactivation.
 
generated with Midjourney

Upcoming presentations - 10.05.2023

Edda presents our work on how signals are decoded at the Xist locus: Gemma presents CasTuner, the CRISPR/Cas-based toolkit for analog tuning of gene expression:
Lab retreat - 10.05.2023

Lab retreat - 10.05.2023

We went on a two-day retreat with the group of Luca Giorgetti!
It started with icebreakers and brief project presentations. For most of the time we brainstormed on our shared research interests to develop several exciting ideas for collaboration. In between we found time for a fun hike and escape room challenge. Thanks to the Giorgetti lab and the EMBO YIP for support!
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Participations in courses - 08.05.2023

Till went to the week-long PhD course of the EMBO Young Investigator Network in Heidelberg. Daniela & Jade participated in a course at the Institut Curie in Paris. Gemma was at the meeting of her PhD training network Pep-NET in Naples. The programs included presenting the own work and workshops on soft skills, grant writing, paper reviewing, research presentations, and more. Elodie joined a course on deep reading of publications.
Presentation prize - 30.03.2023

Presentation prize - 30.03.2023

Our own Daniela Cecalev won a prize for best presentation & participation at the Curie institutes “18th Course on Epigenetics 2023”. Congratulations Daniela !
 
Register now ! - 01.03.2023

Register now ! - 01.03.2023


5th X-inactivation meeting (EMBO)
19-22 June 2023, in Berlin

Registration deadline: 01 April 2023.
25 talks selected from abstracts.
Media - 08.03.2023

Media - 08.03.2023

Some time back, a german film team visited us for a documentary on gender medicine. It's now online, we are in the first part :
Anniversary for Ilona - 01.02.2023

Anniversary for Ilona - 01.02.2023

Ilona celebrates her 40-year anniversary of working at this institute! We are very grateful to have her on our team, managing the lab and doing the most challenging experiments!
New visitor - 15.01.2023

New visitor - 15.01.2023

Rafael Galupa will stay with us for two months to do several CRISPR screens. Welcome!
 
New team member - 04.01.2023

New team member - 04.01.2023

Jonathan Froehlich joins the team as a Postdoc. Welcome!
 
Poster prize - 02.12.2022

Poster prize - 02.12.2022

Our Nelly Kanata won a poster prize at the 2022 Max Planck Freiburg Epigenetics Meeting. Congratulations @nellykanata !
 
PhD program recruitment - 11.11.2022

PhD program recruitment - 11.11.2022

The new round of PhD program recruitment is open, deadline is January 6th, 2023.Our lab proposes two potential projects. One to study how different levels in gene regulatory factors affect cellular decision. The second to study how gene regulatory DNA affects cell-to-cell heterogeneity in transcriptional responses. Both projects will be relevant to better understand gene regulation and cell fate; using CRISPR tools, genomic profiling techniques, and relevant computational analysis.
Preprint - 06.10.2022

Preprint - 06.10.2022

We present CasTuner, a CRISPR-based toolkit that allows analog tuning of endogenous gene expression.
  • CasTuner: a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Noviello G, Rutger RAF, and Schulz EG. BioRxiv 2022
  • Edda & Gemma's tweetorial
Attending conference - 01.10.2022

Attending conference - 01.10.2022

Nelly will attend the “Max Planck Freiburg 6th Epigenetics Meeting”
30 Nov – 02 Dec 2022
Reach out to Nelly Kanata!
https://events.ie-freiburg.mpg.de/3161/1About_the_conference

 
Attending conference - 01.09.2022

Attending conference - 01.09.2022

Till will attend “EMBO - From functional genomics to systems biology”
15 - 18 Nov 2022
Reach out to Till Schwämmle!
https://www.embl.org/about/info/course-and-conference-office/events/omx22-01/
 
Publication - 20.12.2021

Publication - 20.12.2021

We scanned the regulatory landscape of Xist and found several proximal and distal enhancers, as well as a new ncRNA Xert, that all control X-inactivation.
  • Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Gjaltema RAF*, Schwämmle T*, Kautz P, Robson M, Schöpflin R, Lustig LR, Brandenburg L, Dunkel I, Vechiatto C, Ntini E, Mutzel V, Schmiedel V, Marsico A, Mundlos S, Schulz EG. Molecular Cell 2021
  • Preview by Elphège Nora here.
  • Institute’s press release here.
EMBO Young Investigator award for Edda - 08.12.2021

EMBO Young Investigator award for Edda - 08.12.2021

Edda has been accepted by the European Molecular Biology Organization (EMBO) into its Young Investigators Programme. Every year, the organization honors the most promising young researchers in Europe.
  • Institute’s press release here.

 

 

 

...ups, we lost some records here :( please have patience - we are working on recovering them...

 

 

 

Publication - 07.06.2019

Publication - 07.06.2019

Our work together with the Marsico lab, where we use machine learning to identify the rules of Xist-mediated gene silencing was published:
  • Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Barros de Andrade E Sousa L, Jonkers I, Syx L, Dunkel I, Chaumeil J, Picard C, Foret B, Chen CJ, Lis JT, Heard E, Schulz EG, Marsico A. Genome Res. 2019
Publication - 08.04.2019

Publication - 08.04.2019

First mathematical model of Xist regulatory network published. See press release
Media - 21.08.2018

Media - 21.08.2018

As part of the "Max Planck Day" we got a visit from the Youtuber Dr Watson to explain our work on X inactivation.
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