Ilona celebrates her 40-year anniversary of working at this institute! We are very grateful to have her on our team, managing the lab and doing the most challenging experiments!
Rafael visits - 15.01.2023
Rafael Galupa will stay with us for two months to do several CRISPR screens. Welcome!
Jonathan joins - 04.01.2023
Jonathan Froehlich joins the team as a Postdoc. Welcome!
Poster prize for Nelly - 02.12.2022
Our Nelly Kanata won a poster prize at the 2022 Max Planck Freiburg Epigenetics Meeting. Congratulations @nellykanata !
PhD program recruitment - 11.11.2022
The new round of PhD program recruitment is open, deadline is January 6th, 2023.
Our lab proposes two potential projects. One to study how different levels in gene regulatory factors affect cellular decision. The second to study how gene regulatory DNA affects cell-to-cell heterogeneity in transcriptional responses. Both projects will be relevant to better understand gene regulation and cell fate; using CRISPR tools, genomic profiling techniques, and relevant computational analysis.
We scanned the regulatory landscape of Xist and found several proximal and distal enhancers, as well as a new ncRNA Xert, that all control X-inactivation.
Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Gjaltema RAF*, Schwämmle T*, Kautz P, Robson M, Schöpflin R, Lustig LR, Brandenburg L, Dunkel I, Vechiatto C, Ntini E, Mutzel V, Schmiedel V, Marsico A, Mundlos S, Schulz EG.Molecular Cell 2021
EMBO Young Investigator award for Edda - 08.12.2021
Edda has been accepted by the European Molecular Biology Organization (EMBO) into its Young Investigators Programme. Every year, the organization honors the most promising young researchers in Europe.
...ups, we lost some records here :( please have patience - we are working on recovering them...
Publication - 07.06.2019
Our work together with the Marsico lab, where we use machine learning to identify the rules of Xist-mediated gene silencing was published:
Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Barros de Andrade E Sousa L, Jonkers I, Syx L, Dunkel I, Chaumeil J, Picard C, Foret B, Chen CJ, Lis JT, Heard E, Schulz EG, Marsico A. Genome Res. 2019
Publication - 08.04.2019
First mathematical model of Xist regulatory network published. See press release
A symmetric toggle switch explains the onset of random X inactivation in different mammals. Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG. Nature Structural and Molecular Biology 2019
Youtuber Dr Watson visited us - 21.08.2018
As part of the "Max Planck Day" we got a visit from the Youtuber Dr Watson to explain our work on X inactivation.