Selected Publications

Till Schwaemmle, Gemma Noviello, Eleni Kanata, Jonathan J. Froehlich, Melissa Bothe, Aybuge Altay, Jade Scouarnec, Vivi-Yun Feng, Martin Vingron, Edda G Schulz

Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus

BioRxiv (2024)

DOI

Mutzel, V.; Schwämmle, T.; Oeverdieck, S.; Librenjak, L.; Boesen, B.; Bothe, M.; Gjaltema, R. A. F.; Dunkel, I.; Noviello, G.; Schulz, E. G.: Antisense transcription can induce expression memory via stable promoter repression. bioRxiv (2024)

MPG.PuRe

DOI

pre-print

Ravid Lustig L., Sampath Kumar A., Schwämmle T., Dunkel I., Noviello G., Limberg E., Weigert R., Pacini G., Buschow R., Ghauri A., Stötzel M., Wittler L., Meissner A., Schulz EG.

GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers

Nature Cell Biology (2023), 25(11):1704-1715.

DOI

Sultana Z, Dorel M, Klinger B, Sieber A, Dunkel I, Blüthgen N, Schulz EG.

Modeling unveils sex differences of signaling networks in mouse embryonic stem cells.

Molecular Systems Biology (2023), e11510.

DOI

Noviello G, Gjaltema RAF, Schulz EG.

CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression.

Nature Communications (2023), 14(1): 3225.

DOI

Gjaltema, R. A. F.; Schwämmle, T.; Kautz, P.; Robson, M.; Schöpflin, R.; Ravid Lustig, L.; Brandenburg, L.; Dunkel, I.; Vechiatto, C.; Ntini, E. et al.; Mutzel, V.; Schmiedel, V.; Marsico, A.; Mundlos, S.; Schulz, E. G.: Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Molecular Cell 82 (1), pp. 190 - 208 (2022)

MPG.PuRe

DOI

publisher-version

Pacini, G, Dunkel, I, Mages, N, Mutzel, V, Timmermann, B, Marsico, A, and Schulz, E G.

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

Nature Communications 2021, 12.1, 1–17.

Source

DOI

Genolet, O, Monaco, A A, Dunkel, I, Boettcher, M, and Schulz, E G.

Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

Genome Biology 2021, 22

Source

DOI

Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG

A symmetric toggle switch explains the onset of random X inactivation in different mammals.

Nature Structural and Molecular Biology 2019 May;26(5):350-360. Epub 2019 Apr 8.

Source

DOI