Publications
Complete list of our publications
2025
Modeling the impact of double X-dosage on pluripotency maintenance in mouse embryonic stem cells. Dissertation (2025)
2024
187 (23), pp. 6566 - 6583 (2024)
mTOR activity paces human blastocyst stage developmental progression. Cell
Functional investigation of the regulatory landscape around the Xist locus. Dissertation (2024)
Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus. bioRxiv (2024)
56 (10), pp. 2004 - 2005 (2024)
Structural remodeling of the inactive X chromosome during early mouse development. Nature Genetics
Development of a method to tune endogenous gene expression and its application to study dose-sensitivity in transcriptional regulation and random X-chromosome inactivation. Dissertation (2024)
86, Article 102198 (2024)
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation. Current Opinion in Genetics & Development 151 (10), Article dev201741 (2024)
Establishment and maintenance of random monoallelic expression. Development
Antisense transcription can induce expression memory via stable promoter repression. bioRxiv (2024)
84 (3), pp. 413 - 414 (2024)
BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding. Molecular Cell 2023
Transcriptome regulation during the X chromosome inactivation process. Dissertation (2023)
25 (11), pp. 1704 - 1715 (2023)
GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 9 (39), eadg1936 (2023)
Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science Advances 19 (11), e11510 (2023)
Modeling unveils sex differences of signaling networks in mouse embryonic stem cells. Molecular Systems Biology 14 (1), 3225 (2023)
CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications 2022
82 (1), pp. 190 - 208 (2022)
Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Molecular Cell 2520, pp. 1 - 24 (Ed. Turksen, K.). Humana Press, New York, NY (2022)
Dissecting molecular phenotypes through FACS-based pooled CRISPR screens. In: Embryonic Stem Cell Protocols. Methods in Molecular Biology, 2520., Vol. 2021
Experimental and theoretical analysis of X-chromosome inactivation as a paradigm for epigenetic memory and molecular decision-making. Dissertation, 191 pp. (2021)
12 (1), 3638 (2021)
Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution. Nature Communications
Identification of X-chromosomal genes that drive global X-dosage effects in mammals. Dissertation (2021)
22, 110 (2021)
Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology 2020
42 (4), e1900163 (2020)
Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation. Bioessays 2019
29 (7), pp. 1087 - 1099 (2019)
Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Research 26 (5), pp. 350 - 360 (2019)
A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural and Molecular Biology 2018
1767, pp. 167 - 185 (Eds. Jeltsch , A.; Rots, M.). Humana Press, New York (2018)
CRISPR/dCas9 switch systems for temporal transcriptional control. In: Epigenome Editing. Methods in Molecular Biology., Vol. 2017
372 (1733), pii: 20160366 (2017)
X-chromosome dosage as a modulator of pluripotency, signalling and differentiation? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 2017, pp. 1 - 54 (2017)
Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X-chromosome inactivation. bioRxiv: the preprint server for biology 27 (3), pp. 479 - 490 (2017)
Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Research 2014
14 (2), pp. 203 - 2016 (2014)
The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network. Cell Stem Cell 2013
23 (2), pp. 109 - 115 (2013)
Role and control of X chromosome dosage in mammalian development. Current Opinion in Genetics & Development 2012
485 (7398), pp. 381 - 385 (2012)
Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 2011
7 (1), e1002002 (2011)
Rnf12—A Jack of All Trades in X Inactivation? PLoS Genetics 2009
30 (5), pp. 673 - 683 (2009)
Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12. Immunity