Publications

Schwämmle, T.; Noviello, G.; Kanata, E.; Froehlich, J. J.; Bothe, A. M.; Martitz, A.; Altay, A.; Scouarnec, J.; Feng, V.-Y.; Mallie, H. et al.; Vingron, M.; Schulz, E. G.: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus. Nature Structural & Molecular Biology (2025)

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Sultana, Z.: Modeling the impact of double X-dosage on pluripotency maintenance in mouse embryonic stem cells. Dissertation, 178 pp pp. (2025)

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2024

Iyer, D. P.; Khoei , H. H.; van der Weijden, V. A.; Kagawa, H.; Pradhan, S. J.; Novatchkova, M.; McCarthy, A.; Rayon, T.; Simon, C. S.; Dunkel, I. et al.; Wamaitha, S. E.; Elder, K.; Snell , P.; Christie, L.; Schulz, E. G.; Niakan, K. K.; Rivron, N.; Bulut-Karslioglu, A.: mTOR activity paces human blastocyst stage developmental progression. Cell 187 (23), pp. 6566 - 6583 (2024)

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Schwämmle, T.: Functional investigation of the regulatory landscape around the Xist locus. Dissertation (2024)

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Schulz, E. G.; Martitz, A.: Structural remodeling of the inactive X chromosome during early mouse development. Nature Genetics 56 (10), pp. 2004 - 2005 (2024)

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Noviello, G.: Development of a method to tune endogenous gene expression and its application to study dose-sensitivity in transcriptional regulation and random X-chromosome inactivation. Dissertation (2024)

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Pacini, G.: Transcriptome regulation during the X chromosome inactivation process. Dissertation, 124 Seiten pp. (2024)

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Martitz, A.; Schulz, E. G.: Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation. Current Opinion in Genetics & Development 86, Article 102198 (2024)

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Kanata, E.; Duffié, R.; Schulz, E. G.: Establishment and maintenance of random monoallelic expression. Development 151 (10), Article dev201741 (2024)

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Mutzel, V.; Schwämmle, T.; Oeverdieck, S.; Librenjak, L.; Boesen, B.; Bothe, M.; Gjaltema, R. A. F.; Dunkel, I.; Noviello, G.; Schulz, E. G.: Antisense transcription can induce expression memory via stable promoter repression. bioRxiv (2024)

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pre-print

Schulz, E. G.: BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding. Molecular Cell 84 (3), pp. 413 - 414 (2024)

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2023

Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Limberg, E.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A. et al.; Stötzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 25 (11), pp. 1704 - 1715 (2023)

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de Sousa, J. A.; Wong, C.-W.; Dunkel, I.; Owens, T.; Voigt, P.; Hodgson, A.; Baker, D.; Schulz, E. G.; Reik, W.; Smith, A. et al.; Rostovskaya, M.; von Meyenn, F.: Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science Advances 9 (39), eadg1936 (2023)

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Sultana, Z.; Dorel, M.; Klinger, B.; Sieber, A.; Dunkel, I.; Blüthgen, N.; Schulz, E. G.: Modeling unveils sex differences of signaling networks in mouse embryonic stem cells. Molecular Systems Biology 19 (11), e11510 (2023)

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Noviello, G.; Gjaltema, R. A. F.; Schulz, E. G.: CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications 14 (1), 3225 (2023)

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2022

Gjaltema, R. A. F.; Schwämmle, T.; Kautz, P.; Robson, M.; Schöpflin, R.; Ravid Lustig, L.; Brandenburg, L.; Dunkel, I.; Vechiatto, C.; Ntini, E. et al.; Mutzel, V.; Schmiedel, V.; Marsico, A.; Mundlos, S.; Schulz, E. G.: Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Molecular Cell 82 (1), pp. 190 - 208 (2022)

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Genolet, O.; Ravid-Lustig, L.; Schulz, E. G.: Dissecting molecular phenotypes through FACS-based pooled CRISPR screens. In: Embryonic Stem Cell Protocols. Methods in Molecular Biology, 2520., Vol. 2520, pp. 1 - 24 (Ed. Turksen, K.). Humana Press, New York, NY (2022)

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2021

Mutzel, V.: Experimental and theoretical analysis of X-chromosome inactivation as a paradigm for epigenetic memory and molecular decision-making. Dissertation, 191 pp. (2021)

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Pacini, G.; Dunkel, I.; Mages, N.; Mutzel, V.; Timmermann, B.; Marsico, A.; Schulz, E. G.: Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution. Nature Communications 12 (1), 3638 (2021)

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Genolet, O.: Identification of X-chromosomal genes that drive global X-dosage effects in mammals. Dissertation, 140 Seiten pp. (2021)

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Genolet, O.; Monaco, A. A.; Dunkel, I.; Boettcher, M.; Schulz, E. G.: Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology 22, 110 (2021)

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2020

Mutzel, V.; Schulz, E. G.: Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation. Bioessays 42 (4), e1900163 (2020)

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2019

Barros de Andrade e Sousa, L.; Jonkers, I.; Syx, L.; Dunkel, I.; Chaumeil, J.; Picard, C.; Foret, B.; Chen, C.-J.; Lis, J. T.; Heard, E. et al.; Schulz, E. G.; Marsico, A.: Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Research 29 (7), pp. 1087 - 1099 (2019)

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Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural and Molecular Biology 26 (5), pp. 350 - 360 (2019)

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supplementary-material

2018

Gjaltema, R. A. F.; Schulz, E. G.: CRISPR/dCas9 switch systems for temporal transcriptional control. In: Epigenome Editing. Methods in Molecular Biology., Vol. 1767, pp. 167 - 185 (Eds. Jeltsch , A.; Rots, M.). Humana Press, New York (2018)

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2017

Schulz, E. G.: X-chromosome dosage as a modulator of pluripotency, signalling and differentiation? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 372 (1733), pii: 20160366 (2017)

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Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X-chromosome inactivation. bioRxiv: the preprint server for biology 2017, pp. 1 - 54 (2017)

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pre-print

Zhan, Y.; Mariani, L.; Barozzi, I.; Schulz, E. G.; Blüthgen, N.; Stadler, M.; Tiana, G.; Giorgetti, L.: Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Research 27 (3), pp. 479 - 490 (2017)

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2014

Schulz, E. G.; Meisig, J.; Nakamura, T.; Okamoto, I.; Sieber, A.; Picard, C.; Borensztein, M.; Saitou, M.; Blüthgen, N.; Heard, E.: The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network. Cell Stem Cell 14 (2), pp. 203 - 2016 (2014)

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2013

Schulz, E. G.; Heard, E.: Role and control of X chromosome dosage in mammalian development. Current Opinion in Genetics & Development 23 (2), pp. 109 - 115 (2013)

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2012

Nora, E. P.; Lajoie, B. R.; Schulz, E. G.; Giorgetti, L.; Okamoto, I.; Servant, N.; Piolot, T.; van Berkum, N. L.; Meisig, J.; Sedat, J. et al.; Gribnau, J.; Barillot, E.; Blüthgen, N.; Dekker, J.; Heard, E.: Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 485 (7398), pp. 381 - 385 (2012)

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2011

Schulz, E. G.; Nora , E. P.; Heard, E.: Rnf12—A Jack of All Trades in X Inactivation? PLoS Genetics 7 (1), e1002002 (2011)

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2009

Schulz, E. G.; Mariani, L.; Radbruch, A.; Höfer, T.: Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12. Immunity 30 (5), pp. 673 - 683 (2009)

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