Publications

Selected publications

A phase separation model for transcriptional control
Hnisz D*, Shrinivas K*, Young RA, Chakraborty A, Sharp PA.
Cell.  2017 Mar 23;169(1):13-23.  
*co-first author

Transcriptional addiction in cancer
Bradner JE, Hnisz D, Young RA.
Cell. 2017 Feb 9;168(4):629-643. Review.

Insulated neighborhoods: structural and functional units of mammalian gene control
Hnisz D*$, Day DS*$, Young RA$.
Cell. 2016 Nov 17;167(5):1188-1200. Review.
*co-first author, $corresponding author

Activation of proto-oncogenes by disruption of chromosome neighborhoods
Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA.
Science. 2016 Mar 25;351(6280):1454-1458.

3D chromosome regulatory landscape of human pluripotent cells
Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.
Cell Stem Cell. 2016 Feb 4;18(2):262-75.

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
Hnisz D*, Schuijers J*, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA.
Mol Cell. 2015 Apr 16;58(2):362-70. 
*co-first author

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
Dowen JM*, Fan ZP*, Hnisz D*, Ren G*, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA.
Cell. 2014 Oct 9;159(2):374-387. 
*co-first author

Super-enhancers in the control of cell identity and disease
Hnisz D*, Abraham BJ*, Lee TI*, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA.
Cell. 2013 Nov 7;155(4):934-47.   
*co-first author

Master transcription factors and mediator establish super-enhancers at key cell identity genes
Whyte WA*, Orlando DA*, Hnisz D*, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.
Cell. 2013 Apr 11;153(2):307-19.   
*co-first author