Selected Publications
Our top publications
26 (8), pp. 1309 - 1321 (2024)
An activity-specificity trade-off encoded in human transcription factors. Nature Cell Biology
30 (12), pp. 1958 - 1969 (2023)
Rational optimization of a transcription factor activation domain inhibitor. Nature Structural & Molecular Biology
614 (7948), pp. 564 - 571 (2023)
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases. Nature
54 (8), pp. 1238 - 1247 (2022)
Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics
181 (5), pp. 1062 - 1079 (2020)
Unblending of Transcriptional Condensates in Human Repeat Expansion Disease. Cell
A phase separation model for transcriptional control.
Cell. 169( 1), pp. 13-23. (2017)
*co-first author
*co-first author
Transcriptional addiction in cancer.
Cell. 168 (4), pp. 629-643 (2017) Review
Insulated neighborhoods: structural and functional units of mammalian gene control.
Cell 167 (5) pp. 1188-1200 (2016 ) Review
*co-first author, $corresponding author
*co-first author, $corresponding author
Activation of proto-oncogenes by disruption of chromosome neighborhoods.
Science 351 (6280) pp. 1454-1458 (2016)
3D chromosome regulatory landscape of human pluripotent cells.
Cell Stem Cell. 18 (2) pp. 262-75
Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
Mol Cell 58 ( 2) pp. 362-70 (2015)
*co-first author
*co-first author
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes.
Cell 159 (2) pp. 374-387 (2014)
*co-first author
*co-first author
Super-enhancers in the control of cell identity and disease.
Cell 155 (4) pp. 934-47 (2013)
*co-first author
*co-first author
Master transcription factors and mediator establish super-enhancers at key cell identity genes.
Cell 153 (2) pp. 307-19 (2013)
*co-first author
*co-first author