Publications

Selected publications

Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
Mensah, MA*, Niskanen H*, Magalhaes AP, Basu S, Kircher M, Sczakiel HL, Reiter AMV, Elsner J, Meinecke P, Biskup S, Chung B, Dombrowsky G, Eckmann-Scholz C, Hitz MP, Holterhus PM, Hülsemann W, Kahrizi K, Kalscheuer VM, Kan A, Krumbiegel M, Kurth I, Leubner J, Longardt AC, Moritz JD, Najmabadi H, Skipalova K, Tzschach A, Wiedersberg E, Zenker M, Garcia-Cabau C, Buschow R, Salvatella X, Kraushar ML, Mundlos S, Caliebe A, Spielmann M, Horn D, Hnisz D.
Nature. 2023 Feb 8, doi.org/10.1038/s41586-022-05682-1

Hijacking of transcriptional condensates by endogenous retroviruses
Asimi V, Sampath Kumar A, Niskanen H, Riemenschneider C, Hetzel S, Naderi J, Fasching N, Popitsch N, Kretzmer H, Smith Z, Walther M, Meierhofer D, Wittler L, Buschow R, Timmermann B, Ameres SL, Meissner A, Hnisz D
Nature Genetics. 2022 Aug;54(8):1238-1247. doi: 10.1038/s41588-022-01132-w.

Unblending of transcriptional condensates in human repeat expansion disease
Basu S, Mackowiak SD, Niskanen H, Knezevic D, Asimi V, Grosswendt S, Geertsema H, Ali S, Jerkovic I, Ewers H, Mundlos S, Meissner A, Ibrahim DI, Hnisz D.
Cell. 2020 May 28;181(5):1062-1079.e30.

A phase separation model for transcriptional control
Hnisz D*, Shrinivas K*, Young RA, Chakraborty A, Sharp PA.
Cell.  2017 Mar 23;169(1):13-23.  
*co-first author

Transcriptional addiction in cancer
Bradner JE, Hnisz D, Young RA.
Cell. 2017 Feb 9;168(4):629-643. Review.

Insulated neighborhoods: structural and functional units of mammalian gene control
Hnisz D*$, Day DS*$, Young RA$.
Cell. 2016 Nov 17;167(5):1188-1200. Review.
*co-first author, $corresponding author

Activation of proto-oncogenes by disruption of chromosome neighborhoods
Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA.
Science. 2016 Mar 25;351(6280):1454-1458.

3D chromosome regulatory landscape of human pluripotent cells
Ji X, Dadon DB, Powell BE, Fan ZP, Borges-Rivera D, Shachar S, Weintraub AS, Hnisz D, Pegoraro G, Lee TI, Misteli T, Jaenisch R, Young RA.
Cell Stem Cell. 2016 Feb 4;18(2):262-75.

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
Hnisz D*, Schuijers J*, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA.
Mol Cell. 2015 Apr 16;58(2):362-70. 
*co-first author

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
Dowen JM*, Fan ZP*, Hnisz D*, Ren G*, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA.
Cell. 2014 Oct 9;159(2):374-387. 
*co-first author

Super-enhancers in the control of cell identity and disease
Hnisz D*, Abraham BJ*, Lee TI*, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA.
Cell. 2013 Nov 7;155(4):934-47.   
*co-first author

Master transcription factors and mediator establish super-enhancers at key cell identity genes
Whyte WA*, Orlando DA*, Hnisz D*, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.
Cell. 2013 Apr 11;153(2):307-19.   
*co-first author