Foto: David Ausserhofer

Dr. Sara Hetzel

Postdoc

Kretzmer Lab
(030) 8413 1269

1.3.71

Curriculum Vitae

Sara obtained her Bachelor’s and Master’s degree in Bioinformatics from the Freie Universität Berlin. She conducted the research for her Master thesis as an exchange student at the CSIRO in Sydney studying off-target effects of CRISPR-Cas9. After her return, Sara joined Alex’s lab as a PhD student, investigating the role of DNA methylation in human cancer and matching mouse models.

Publications

Journal Article

Hetzel, S.; Hodis , E.; Torlai Triglia, E.; Kovacsovics, A.; Steinmann , K.; Gnirke, A.; Cui, M.; McQuaid, D.; Weigert, R.; Pohl, G. et al.; Muzumdar, M. D.; Leyvraz, S.; Keilholz, U.; Yaspo, M.-L.; Regev, A.; Kretzmer, H.; Smith, Z.; Meissner, A.: Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biology (26) (2025)

MPG.PuRe

DOI

publisher-version

Review Article

Smith, Z. D.; Hetzel, S.; Meissner, A.: DNA methylation in mammalian development and disease. Nature Reviews Genetics 26 (1), pp. 7 - 30 (2025)

MPG.PuRe

DOI

publisher-version

Journal Article

Batki, J.; Hetzel, S.; Schifferl, D.; Bolondi, A.; Walther, M.; Wittler, L.; Grosswendt, S.; Herrmann, B. G.; Meissner, A.: Extraembryonic gut endoderm cells undergo programmed cell death during development. Nature Cell Biology 26 (6), pp. 868 - 877 (2024)

MPG.PuRe

DOI

publisher-version

Thesis - PhD

Hetzel, S.: Investigation of DNA methylation heterogeneity in cancer. Dissertation, xix, 198 pp pp. (2024)

MPG.PuRe

DOI

Full

Journal Article

Hauswedell , H.; Hetzel, S.; Gottlieb , S. G.; Kretzmer, H.; Meissner, A.; Reinert, K.: Lambda3: homology search for protein, nucleotide, and bisulfite-converted sequences. Bioinformatics 40 (3), Article btae097 (2024)

MPG.PuRe

DOI

publisher-version

Journal Article

Klever, M.-K.; Sträng , E.; Hetzel, S.; Jungnitsch, J.; Dolnik, A.; Schöpflin, R.; Schrezenmeier, J.-F.; Schick, F.; Blau, O.; Westermann, J. et al.; Rücker , F. G. ..; Xia, Z.; Döhner, K.; Schrezenmeier, H.; Spielmann, M.; Meissner, A.; Melo, U. S.; Mundlos, S.; Bullinger, L.: AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology. Blood Advances 7 (21), pp. 6520 - 6531 (2023)

MPG.PuRe

DOI

publisher-version

Journal Article

Weigert, R.; Hetzel, S.; Bailly, N.; Haggerty, C.; Ilik, I. A.; Kwong Yung, P. Y.; Navarro, C.; Bolondi, A.; Sampath Kumar, A.; Anania, C. et al.; Brändl, B.; Meierhofer, D.; Lupiáñez, D. G.; Müller, F.-J.; Aktas, T.; Elsässer, S. J.; Kretzmer, H.; Smith, Z. D.; Meissner, A.: Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nature Cell Biology 25 (4), pp. 579 - 591 (2023)

MPG.PuRe

DOI

publisher-version

Journal Article

Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Glaser, J.; Phan, M. H. Q.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S. A.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M. I.: Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Cell 185 (20), pp. 3689 - 3704 (2022)

MPG.PuRe

DOI

publisher-version

Journal Article

Asimi, V.; Sampath Kumar, A.; Niskanen, H.; Riemenschneider, C.; Hetzel, S.; Naderi, J.; Fasching, N.; Popitsch, N.; Du, M.; Kretzmer, H. et al.; Smith, Z. D.; Weigert, R.; Walther, M.; Mamde, S.; Meierhofer, D.; Wittler, L.; Buschow, R.; Timmermann, B.; Cisse, I. I.; Ameres, S. L.; Meissner, A.; Hnisz, D.: Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics 54 (8), pp. 1238 - 1247 (2022)

MPG.PuRe

DOI

publisher-version

10.

Journal Article

Hetzel, S.; Mattei, A. L.; Kretzmer, H.; Qu, C.; Chen, X.; Fan, Y.; Wu, G.; Roberts, K. G.; Luger, S.; Litzow, M. et al.; Rowe, J.; Paietta, E.; Stock, W.; Mardis, E. R.; Wilson, R. K.; Downing, J. R.; Mullighan, C. G.; Meissner, A.: Acute lymphoblastic leukemia displays a distinct highly methylated genome. Nature Cancer 3 (6), pp. 768 - 782 (2022)

MPG.PuRe

DOI

publisher-version