Publikationen von Lars Wittler

Francisca M. Real, Stefan A. Haas, Paolo Franchini, Peiwen Xiong, Oleg Simakov, Heiner Kuhl, Robert Schöpflin, David Heller, Mohammad Hossein Moeinzadeh, Verena Heinrich, Thomas Krannich , Annkatrin Bressin, Michaela F. Hartmann, Stefan A. Wudy, Dina K. N. Dechmann, Alicia Hurtado, Francisco J. Barrionuevo, Magdalena Schindler, Izabela Harabula, Marco Osterwalder, Michael Hiller, Lars Wittler, Axel Visel, Bernd Timmermann, Axel Meyer, Martin Vingron, Rafael Jiménez, Stefan Mundlos, and Dario G. Lupiáñez, "The mole genome reveals regulatory rearrangements associated with adaptive intersexuality," Science 370 (6513), 208-214 (2020).

Johanna Magdalena Rieke, Rong Zhang, Doreen Braun, Öznur Yilmaz, Anna S. Japp, Filipa M. Lopes, Michael Pleschka, Alina C. Hilger, Sophia Schneider, William G. Newman, Glenda M. Beaman, Agneta Nordenskjöld, Anne-Karoline Ebert, Martin Promm, Wolfgang H. Roesch, Raimund Stein, Karin Hirsch, Frank-Mattias Schäfer, Eberhard Schmiedeke, Thomas M. Boemers, Martin Lacher, Dietrich Kluth, Jan-Hendrik Gosemann, Magnus Anderberg, Gillian Barker, Gundela Holmdahl, Göran Läckgren, David Keene, Raimondo M. Cervellione, Elisa Giorgio, Massimo Di Grazia, Feitz F. J. Wouter, Carlo L. M. Marcelis, Iris A. L. M. Van Rooij, Arend Bökenkamp, Goedele M. A. Beckers, Catherine E. Keegan, Amit Sharma, Tikam Chand Dakal, Lars Wittler, Phillip Grote, Nadine Zwink, Ekkehart Jenetzky, Alfredo Brusco, Holger Thiele, Michael Ludwig, Ulrich Schweizer, Adrian S. Woolf, Benjamin Odermatt, and Heiko Reutter, "SLC20A1 Is Involved in Urinary Tract and Urorectal Development," Frontiers in Cell and Developmental Biology 8, 567 (2020).

Stefanie Grosswendt, Helene Kretzmer, Zachary D. Smith, Abhishek Sampath Kumar, Sara Hetzel, Lars Wittler, Sven Klages, Bernd Timmermann, Shankar Mukherji, and Alexander Meissner, "Epigenetic regulator function through mouse gastrulation," Nature 584, 102-108 (2020).

Alexandra Despang, Robert Schöpflin, Martin Franke, Salaheddine Ali, Ivana Jerković, Christina Paliou, Wing-Lee Chan, Bernd Timmermann, Lars Wittler, Martin Vingron, Stefan Mundlos, and Daniel M. Ibrahim, "Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture," Nature Genetics 51 (8), 1263-1271 (2019).

Christina Paliou, Philine Guckelberger, Robert Schöpflin, Verena Heinrich, Andrea Esposito, Andrea M. Chiariello, Simona Bianco, Carlo Annunziatella, Johannes Helmuth, Stefan Haas, Ivana Jerković, Norbert Brieske, Lars Wittler, Bernd Timmermann, Mario Nicodemi, Martin Vingron, Stefan Mundlos, and Guillaume Andrey, "Preformed Chromatin Topology Assists Transcriptional Robustness of Shh during Limb Development," Proceedings of the National Academy of Sciences of the United States of America 116 (25), 12390-12399 (2019).

Katerina Kraft, Andreas Magg, Verena Heinrich, Christina Riemenschneider, Robert Schöpflin, Julia Markowski, Daniel Ibrahim, Rocío Acuna-Hidalgo, Alexandra Despang, Guillaume Andrey, Lars Wittler, Bernd Timmermann, Martin Vingron, and Stefan Mundlos, "Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations," Nature Cell Biology 21 (3), 305-310 (2019).

Bjørt K. Kragesteen , Malte Spielmann, Christina Paliou, Verena Heinrich, Robert Schöpflin, Andrea Esposito, Carlo Annunziatella, Simona Bianco , Andrea M. Chiariello, Ivana Jerković , Izabela Harabula, Philine Guckelberger, Michael Pechstein, Lars Wittler, Wing-Lee Chan, Martin Franke, Darío G. Lupiáñez , Katerina Kraft, Bernd Timmermann, Martin Vingron, Axel Visel, Mario Nicodemi, Stefan Mundlos, and Guillaume Andrey, "Dynamic 3D chromatin architecture determines enhancer specificity and morphogenetic identity in limb development," Nature Genetics 50 (10), 1463-1473 (2018).

Ricarda Flöttmann, Bjørt K. Kragesteen, Sinje Geuer, Magdalena Socha, Lila Allou, Anna Sowińska-Seidler, Laure Bosquillon de Jarcy, Johannes Wagner, Aleksander Jamsheer, Barbara Oehl-Jaschkowitz, Lars Wittler, Deepthi de Silva, Ingo Kurth, Idit Maya, Fernando Santos-Simarro, Wiebke Hülsemann, Eva Klopocki, Roger Mountford, Alan Fryer, Guntram Borck, Denise Horn, Pablo Lapunzina, Meredith Wilson, Bénédicte Mascrez, Denis Duboule, Stefan Mundlos, and Malte Spielmann, "Noncoding copy-number variations are associated with congenital limb malformation," GENETICS IN MEDICINE 20 (6), 599-607 (2018).

Simona Bianco, Darío G. Lupiáñez, Andrea M. Chiariello, Carlo Annunziatella, Katerina Kraft, Robert Schöpflin, Lars Wittler, Guillaume Andrey, Martin Vingron, Ana Pombo, Stefan Mundlos, and Mario Nicodemi, "Polymer physics predicts the effects of structural variants on chromatin architecture," Nature Genetics 50 (5), 662-667 (2018).

Arica Beisaw, Pavel Tsaytler, Frederic Koch, Sandra U. Schmitz, Maria-Theodora Melissari, Anna D. Senf, Lars Wittler, Tracie Pennimpede, Karol Macura, Bernhard G. Herrmann, and Phillip Grote, "BRACHYURY directs histone acetylation to target loci during mesoderm development," EMBO Reports 19 (1), 118-134 (2018).

A. J. Will , G. Cova, M. Osterwalder, W. L. Chan, L. Wittler, N. Brieske, V. Heinrich, J. P. de Villartay, M. Vingron, E. Klopocki, A. Visel, D. G. Lupianez, and S. Mundlos, "Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)," Nature Genetics 49 (10), 1539-1545 (2017).

Frederic Koch, Manuela Scholze, Lars Wittler, Dennis Schifferl, Smita Sudheer, Phillip Grote, Bernd Timmermann, Karol Macura, and Bernhard G. Herrmann, "Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors," Developmental Cell 42, 514-526 (2017).

Lisette Lange, Matthias Marks, Jinhua Liu, Lars Wittler, Hermann Bauer, Sandra Piehl, Gabriele Bläß, Bernd Timmermann, and Bernhard G. Herrmann, "Pattering and gastrulation deffects caused by the tw18 lethal are due to loss of Ppp2r1a," Biology Open 6 (6), 752-764 (2017).

Martin Franke, Daniel Ibrahim, Guillaume Andrey, Wibke Schwarzer, Verena Heinrich, Robert Schöpflin, Katerina Kraft, Rieke Kempfer, Ivana Jerković, Wing-Lee Chan, Malte Spielmann, Bernd Timmermann, Lars Wittler, Ingo Kurth, Paola Cambiaso, Orsetta Zuffardi, Gunnar Houge, Lindsay Lambie, Francesco Brancati, Ana Pombo, Martin Vingron, Francois Spitz, and Stefan Mundlos, "Formation of novel chromatin domains determines pathogenicity of genomic duplications," Nature 538 (7624), 265-269 (2016).

Smita Sudheer, Jinhua Liu, Mathias Marks, Frederic Koch, Anna Anurin, Manuela Scholze, Anna Dorothea Senft, Lars Wittler, Karol Macura, Phillip Grote, and Bernhard G. Herrmann, "Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm.," Stem Cells 34 (7), 1790-800 (2016).

Malte Spielmann, Naseebullah Kakar, Naeimeh Tayebi, Catherine Leettola, Gudrun Nürnberg, Nadine Sowada, Darío G. Lupiáñez, Izabela Harabula, Ricarda Flöttmann, Denise Horn, Wing Lee Chan, Lars Wittler, Rüstem Yilmaz, Janine Altmüller, Holger Thiele, Hans van Bokhoven,, Charles E. Schwartz, Peter Nürnberg, James U. Bowie, Jamil Ahmad, Christian Kubisch, and Stefan Mundlos, "Exome Sequencing and CRISPR/Cas Genome Editing Identify Mutations of ZAK as a Cause of Limb Defects in Humans and Mice.," Genome Research 26 (2), 183-191 (2016).

Matthias Marks, Tracie Pennimpede, Lisette Lange, Phillip Grote, Bernhard G. Herrmann, and Lars Wittler, "Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function," Gene 575 (2 Pt 2), 438-451 (2016).

Darío G. Lupiáñez, Katerina Kraft, Verena Heinrich, Peter Krawitz, Francesco Brancati, Eva Klopocki, Denise Horn, Hülya Kayserili, John M. Opitz, Renata Laxova, Fernando Santos-Simarro, Brigitte Gilbert-Dussardier, Lars Wittler, Marina Borschiwer, Stefan A. Haas, Marco Osterwalder, Martin Franke, Bernd Timmermann, Jochen Hecht, Malte Spielmann, Axel Visel, and Stefan Mundlos, "Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions," Cell 161 (5), 1012-1025 (2015).

K. Kraft, S. Geuer, A. J. Will, W. L. Chan, C. Paliou, M. Borschiwer, I. Harabula, L. Wittler, M. Franke, D. Ibrahim, B. K. Kragesteen, M. Spielmann, S. Mundlos, D. G. Lupianez, and G. Andrey, "Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice," Cell Reports 10 (5), 833-839 (2015).

H. Reutter, M. Draaken, T. Pennimpede, L. Wittler, F. F. Brockschmidt, A. K. Ebert, E. Bartels, W. Rösch, T. M. Boemers, K. Hirsch, E. Schmiedeke, C. Meesters, T. Becker, R. Stein, B. Utsch, E. Mangold, A. Nordenskjöld, G. Barker, C. C. Kockum, N. Zwink, G. Homdahl, G. Läckgren, E. Jenetzky, W. F. Feitz, C. Marcelis, C. H. Wijers, I. A. Van Rooij, J. P. Gearhart, B. G. Herrmann, M. Ludwig, S. A. Boyadjiev, M. M. Nöthen, and M. Mattheisen, "Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder," Human Molecular Genetics 23 (20), 5536-5544 (2014).