Publikationen von Lars Wittler

Pavel Tsaytler, Gaby Blaess, Manuela Scholze-Wittler, David Meierhofer, Lars Wittler, Frederic Koch, and Bernhard G. Herrmann, "SRF promotes long-range chromatin loop formation and stem cell pluripotency," Cell Reports 43 (10), 114846 (2024).

Julia Batki, Sara Hetzel, Dennis Schifferl, Adriano Bolondi, Maria Walther, Lars Wittler, Stefanie Grosswendt, Bernhard G. Herrmann, and Alexander Meissner, "Extraembryonic gut endoderm cells undergo programmed cell death during development," Nature Cell Biology 26 (6), 868-877 (2024).

Dhanur P. Iyer, Lambert Moyon, Francisca R. Ringeling, Chieh-Yu Cheng, Lars Wittler, Stefan Canzar, Annalisa Marsico, and Aydan Bulut-Karslioglu, "Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy," Genome Research 34 (4), 589-589 (2024).

Xingfan Huang, Jana Henck, Chengxiang Qiu, Varun K. A. Sreenivasan, Saranya Balachandran, Oana V. Amarie, Martin Hrabě de Angelis, Rose Yinghan Behncke, Wing-Lee Chan, Alexandra Despang, Diane E. Dickel, Madeleine Duran, Annette Feuchtinger, Helmut Fuchs, Valerie Gailus-Durner, Natja Haag, Rene Hägerling, Nils Hansmeier, Friederike Hennig, Cooper Marshall, Sudha Rajderkar, Alessa Ringel, Michael I. Robson, Lauren M. Saunders, Patricia da Silva-Buttkus, Nadine Spielmann, Sanjay R. Srivatsan, Sascha Ulferts, Lars Wittler, Yiwen Zhu, Vera M. Kalscheuer, Daniel M. Ibrahim, Ingo Kurth, Uwe Kornak, Axel Visel, Len A. Pennacchio, David R. Beier, Cole Trapnell, Junyue Cao, Jay Shendure, and Malte Spielmann, "Single-cell, whole-embryo phenotyping of mammalian developmental disorders," Nature 623 (7988), 772-781 (2023).

Dennis Schifferl, Manuela Scholze-Wittler, Alba Villaronga Luque, Milena Pustet , Lars Wittler, Jesse V. Veenvliet, Frederic Koch, and Bernhard G. Herrmann, "Genome-wide identification of notochord enhancers comprising the regulatory landscape of the Brachyury (T) locus in mouse," Development 150 (22), dev202111 (2023).

Liat Ravid Lustig, Abhishek Sampath Kumar, Till Schwämmle, Ilona Dunkel, Gemma Noviello, Elodie Limberg, Raha Weigert, Guido Pacini, René Buschow, Afrah Ghauri, Maximilian Stötzel, Lars Wittler, Alexander Meissner, and Edda G. Schulz, "GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers," Nature Cell Biology 25 (11), 1704-1715 (2023).

Abhishek Sampath Kumar, Luyi Tian, Adriano Bolondi, Amèlia Aragonés Hernández, Robert Stickels, Helene Kretzmer, Evan Murray, Lars Wittler, Maria Walther, Gabriel Barakat, Leah Haut, Yechiel Elkabetz, Evan Z. Macosko, Léo Guignard, Fei Chen, and Alexander Meissner, "Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis," Nature Genetics 55 (7), 1176-1185 (2023).

Pavel Tsaytler, Jinhua Liu, Gabi Blaess, Dennis Schifferl, Jesse V. Veenvliet, Lars Wittler, Bernd Timmermann, Bernhard G. Herrmann, and Frederic Koch, "BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage," Development , dev.201450 (2023).

Giulia Cova, Juliane Glaser, Robert Schöpflin, Salaheddine Ali, César A. Prada-Medina, Martin Franke, Rita Falcone, Miriam Federer, Emanuela Ponzi, Romina Ficarella, Francesca Novara, Lars Wittler, Bernd Timmermann, Mattia Gentile, Orsetta Zuffardi, Malte Spielmann, and Stefan Mundlos, "Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3," Nature Communications 14, 1475 (2023).

M. Schindler, M. Osterwalder, I. Harabula, L. Wittler, A. C. Tzika, Dina K. N. Dechmann, M. Vingron, A. Visel, S. Haas, and F. M. Real, "Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes," Development 150 (17), dev201562 (2023).

Magdalena Schindler, Marco Osterwalder, Izabela Harabula, Lars Wittler, Athanasia C. Tzika, Dina Dechmann, Martin Vingron, Axel Visel, Stefan Haas, and Francisca M. Real, "Co-option of the transcription factor SALL1 in mole ovotestis formation," bioRxiv , 514220 (2022).

Alessa Ringel, Quentin Szabo, Andrea M. Chiariello, Konrad Chudzik, Robert Schöpflin, Patricia Rothe, Alexandra L. Mattei, Tobias Zehnder, Dermot Harnett, Verena Laupert, Simona Bianco, Sara Hetzel, Juliane Glaser, Mai H. Q. Phan, Magdalena Schindler, Daniel M. Ibrahim, Christina Paliou, Andrea Esposito, César A. Prada-Medina, Stefan A. Haas, Peter Giere, Martin Vingron, Lars Wittler, Alexander Meissner, Mario Nicodemi, Giacomo Cavalli, Frédéric Bantignies, Stefan Mundlos, and Michael I. Robson, "Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes," Cell 185 (20), 3689-3704 (2022).

Vahid Asimi, Abhishek Sampath Kumar, Henri Niskanen, Christina Riemenschneider, Sara Hetzel, Julian Naderi, Nina Fasching, Niko Popitsch, Manyu Du, Helene Kretzmer, Zachary D. Smith, Raha Weigert, Maria Walther, Sainath Mamde, David Meierhofer, Lars Wittler, Rene Buschow, Bernd Timmermann, Ibrahim I. Cisse, Stefan L. Ameres, Alexander Meissner, and Denes Hnisz, "Hijacking of transcriptional condensates by endogenous retroviruses," Nature Genetics 54, 1238-1247 (2022).

Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, and Micha Drukker, "Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction," Scientific Reports 12, 3100 (2022).

Maayan Pour, Abhishek Sampath Kumar, Naama Farag, Adriano Bolondi, Helene Kretzmer, Maria Walther, Lars Wittler, Alexander Meissner, and Iftach Nachman, "Emergence and patterning dynamics of mouse-definitive endoderm," iScience 25 (1), 103556 (2022).

Dennis Schifferl, Manuela Scholze-Wittler, Lars Wittler, Jesse V. Veenvliet, Frederic Koch, and Bernhard G. Herrmann, "A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development," Development 148 (23), dev200059 (2021).

Chuck Haggerty, Helene Kretzmer, Christina Riemenschneider, Abhishek Sampath Kumar, Alexandra L. Mattei, Nina Bailly, Judith Gottfreund, Pay Giesselmann, Raha Weigert, Björn Brändl, Pascal Giehr, Rene Buschow, Christina Galonska, Ferdinand von Meyenn, Melissa B. Pappalardi, Michael T. McCabe, Lars Wittler, Claudia Giesecke-Thiel, Thorsten Mielke, David Meierhofer, Bernd Timmermann, Franz-Josef Müller, Jörn Walter, and Alexander Meissner, "Dnmt1 has de novo activity targeted to transposable elements," Nature Structural and Molecular Biology 28 (7), 594-603 (2021).

Lila Allou, Sara Balzano, Andreas Magg, Mathieu Quinodoz, Beryl Royer-Bertrand, Robert Schöpflin, Wing-Lee Chan, Carlos E. Speck-Martins, Daniel Rocha Carvalho, Luciano Farage, Charles Marques Lourenço, Regina Albuquerque, Srilakshmi Rajagopal, Sheela Nampoothiri, Belinda Campos-Xavier, Carole Chiesa, Florence Niel-Bütschi, Lars Wittler, Bernd Timmermann, Malte Spielmann, Michael Robson, Alessa Ringel, Verena Heinrich, Giulia Cova, Guillaume Andrey , Cesar A. Prada-Medina, Rosanna Pescini-Gobert, Sheila Unger, Luisa Bonafé, Phillip Grote, Carlo Rivolta, Stefan Mundlos, and Andrea Superti-Furga, "Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator," Nature 592 (7852), 93-98 (2021).

Miguel Rodríguez de Los Santos, Marion Rivalan, Friederike S. David, Alexander Stumpf, Julika Pitsch, Despina Tsortouktzidis, Laura Moreno Velasquez, Anne Voigt, Karl Schilling, Daniele Mattei, Melissa Long, Guido Vogt, Alexej Knaus, Björn Fischer-Zirnsak, Lars Wittler, Bernd Timmermann, Peter N. Robinson , Denise Horn, Stefan Mundlos, Uwe Kornak, Albert J. Becker, Dietmar Schmitz , York Winter, and Peter M. Krawitz, "A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions," Proceedings of the National Academy of Sciences of the United States of America 118 (2), e2014481118 (2021).

Jesse V. Veenvliet, Adriano Bolondi, Helene Kretzmer, Leah Haut, Manuela Scholze-Wittler, Dennis Schifferl, Frederic Koch, Léo Guignard, Abhishek Sampath Kumar, Milena Pustet, Simon Heimann, Rene Buschow, Lars Wittler, Bernd Timmermann, Alexander Meissner, and Bernhard G. Herrmann, "Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites," Science 370 (6522), eaba4937 (2020).