Publikationen von Denes Hnisz

Julian Naderi, Alexandre P. Magalhães, Gözde Kibar, Gregoire Stik, Yaotian Zhang, Sebastian Mackowiak, Hannah M. Wieler, Francesca Rossi, René Buschow, Marie Christou-Kent, Marc Alcoverro-Bertran, Thomas Graf, Martin Vingron, and Denes Hnisz, "An activity-specificity trade-off encoded in human transcription factors," Nature Cell Biology 26 (8), 1309-1321 (2024).

Shaon Basu, Paula Martínez-Cristóbal, Marta Frigolé-Vivas, Mireia Pesarrodona, Michael Lewis, Elzbieta Szulc, C. Adriana Bañuelos, Carolina Sánchez-Zarzalejo, Stasė Bielskutė, Jiaqi Zhu, Karina Pombo-García, Carla Garcia-Cabau, Levente Zodi, Hannes Dockx, Jordann Smak, Harpreet Kaur, Cristina Batlle, Borja Mateos, Mateusz Biesaga, Albert Escobedo, Lídia Bardia, Xavier Verdaguer, Alessandro Ruffoni, Nasrin R. Mawji, Jun Wang, Jon K. Obst, Teresa Tam, Isabelle Brun-Heath, Salvador Ventura, David Meierhofer, Jesús García, Paul Robustelli, Travis H. Stracker, Marianne D. Sadar, Antoni Riera, Denes Hnisz, and Xavier Salvatella, "Rational optimization of a transcription factor activation domain inhibitor," Nature Structural & Molecular Biology 30 (12), 1958-1969 (2023).

Annkatrin Bressin, Olga Jasnovidova, Mirjam Arnold, Elisabeth Altendorfer, Filip Trajkovski , Thomas A. Kratz, Joanna E. Handzlik, Denes Hnisz, and Andreas Mayer, "High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription," Nature Communications 14 (1), Article 4971 (2023).

Marie Christou-Kent, Sergi Cuartero, Carla Garcia-Cabau, Julia Ruehle, Julian Naderi, Julia Erber, Maria Victoria Neguembor, Marcos Plana-Carmona, Marc Alcoverro-Bertran, Luisa De Andres-Aguayo, Antonios Klonizakis, Eric Julià-Vilella, Cian Lynch, Manuel Serrano, Denes Hnisz, Xavier Salvatella, Thomas Graf, and Grégoire Stik, "CEBPA phase separation links transcriptional activity and 3D chromatin hubs," Cell Reports 42 (8), 112897 (2023).

Marion Dejosez, Alessandra Dall’Agnese, Mahesh Ramamoorthy, Jesse Platt, Xing Yin, Megan Hogan, Ran Brosh, Abraham S. Weintraub, Denes Hnisz, Brian J. Abraham, Richard A. Young, and Thomas P. Zwaka, "Regulatory architecture of housekeeping genes is driven by promoter assemblies," Cell Reports 42 (5), 112505 (2023).

Martin A. Mensah, Henri Niskanen, Alexandre P. Magalhães, Shaon Basu, Martin Kircher, Henrike L. Sczakiel, Alisa M. V. Reiter, Jonas Elsner, Peter Meinecke, Saskia Biskup, Brian H. Y. Chung, Gregor Dombrowsky, Christel Eckmann-Scholz, Marc Phillip Hitz, Alexander Hoischen, Paul-Martin Holterhus, Wiebke Hülsemann, Kimia Kahrizi, Vera M. Kalscheuer, Anita Kan, Mandy Krumbiegel, Ingo Kurth, Jonas Leubner, Ann Carolin Longardt, Jörg D. Moritz, Hossein Najmabadi, Karolina Skipalova, Lot Snijders Blok, Andreas Tzschach, Eberhard Wiedersberg, Martin Zenker, Carla Garcia-Cabau, Rene Buschow, Xavier Salvatella, Matthew L. Kraushar, Stefan Mundlos, Almuth Caliebe, Malte Spielmann, Denise Horn, and Denes Hnisz, "Aberrant phase separation and nucleolar dysfunction in rare genetic diseases," Nature 614 (7948), 564-571 (2023).

Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, Rene Buschow, Alina Rose, Hua-Jun Wu, Sebastian D. Mackowiak, Bjoern Braendl, Pay Gießelmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L. Rinn, and Alexander Meissner, "T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation," eLife 12, e83077 (2023).

Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, Rene Buschow, Alina Rose, Hua-Jun Wu, Sebastian Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L. Rinn, and Alexander Meissner, "Discovery and characterization of LNCSOX17 as an essential regulator in human endoderm formation," bioRxiv (Preprint Server) (2022).

Vahid Asimi, Abhishek Sampath Kumar, Henri Niskanen, Christina Riemenschneider, Sara Hetzel, Julian Naderi, Nina Fasching, Niko Popitsch, Manyu Du, Helene Kretzmer, Zachary D. Smith, Raha Weigert, Maria Walther, Sainath Mamde, David Meierhofer, Lars Wittler, Rene Buschow, Bernd Timmermann, Ibrahim I. Cisse, Stefan L. Ameres, Alexander Meissner, and Denes Hnisz, "Hijacking of transcriptional condensates by endogenous retroviruses," Nature Genetics 54, 1238-1247 (2022).

Biniam Adane, Gabriela Alexe, Bo Kyung A. Seong, Diana Lu, Elizabeth E. Hwang, Denes Hnisz, Caleb A. Lareau, Linda Ross, Shan Lin, Filemon S. Dela Cruz, Melissa Richardson, Abraham S. Weintraub, Sarah Wang, Amanda Balboni Iniguez, Neekesh V. Dharia, Amy Saur Conway, Amanda L. Robichaud, Benjamin Tanenbaum, John M. Krill-Burger, Francisca Vazquez, Monica Schenone, Jason N. Berman, Andrew L. Kung, Steven A. Carr, Martin J. Aryee, Richard A. Young, Brian D. Crompton, and Kimberly Stegmaier, "STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma," Cancer Cell 39 (6), 827-844 (2021).

M. G. Jaeger, B. Schwalb, S. D. Mackowiak, T. Velychko, A. Hanzl, H. Imrichova, M. Brand, B. Agerer, S. Chorn, B. Nabet, F. M. Ferguson, A. C. Müller, A. Bergthaler, N. S. Gray, J. E. Bradner, C. Bock, Denes Hnisz, P. Cramer, and G. E. Winter, "Selective Mediator dependence of cell-type-specifying transcription," Nature Genetics 52 (7), 719-727 (2020).

Shaon Basu, Sebastian Mackowiak, Henri Niskanen, Dora Knezevic, Vahid Asimi, Stefanie Grosswendt, Hylkje Geertsema, Salaheddine Ali, Ivana Jerković, Helge Ewers, Stefan Mundlos, Alexander Meissner, Daniel M. Ibrahim, and Denes Hnisz, "Unblending of Transcriptional Condensates in Human Repeat Expansion Disease," Cell 181 (5), 1062-1079 (2020).

Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A. Klein, Eliot L. Coffey, Krishna Shrinivas, Brian J. Abraham, Nancy M. Hannett, Alicia V. Zamudio, John C. Manteiga, Charles H. Li, Yang E. Guo, Daniel S. Day, Jurian Schuijers, Eliza Vasile, Sohail Malik, Denes Hnisz, Tong Ihn Lee, Ibrahim I. Cisse, Robert G. Roeder, Phillip A. Sharp, Arup K. Chakraborty, and Richard A. Young, "Coactivator condensation at super-enhancers links phase separation and gene control," Science (6400), eaar3958 (2018).

Jurian Schuijers, John Colonnese Manteiga, Abraham Selby Weintraub, Daniel Sindt Day, Alicia Viridiana Zamudio, Denes Hnisz, Tong Ihn Lee, and Richard Allen Young, "Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism," Cell Reports 23 (2), 349-360 (2018).

Julian Naderi, The dispersion of aromatic residues in TF IDRs controls a molecular trade-off between activity and specificity, PhD Thesis, 2024.

Shaon Basu, Genetic and chemical hydrophobic modification of transcription factor condensates in human disease, PhD Thesis, 2023.

Benjamin R. Sabari, Anthony A. Hyman, and Denes Hnisz, "Functional specificity in biomolecular condensates revealed by genetic complementation", in Nature Reviews Genetics, (Nature Pub. Group, London, UK, 2025), Vol. 26, pp. 279-290.

Shaon Basu, Paula Martínez-Cristóbal, Mireia Pesarrodona, Marta Frigolé-Vivas, Elzbieta Szulc, Michael Lewis, C. Adriana Bañuelos, Carolina Sánchez-Zarzalejo, Stasė Bielskutė, Jiaqi Zhu, Carla Garcia-Cabau, Cristina Batlle, Borja Mateos, Mateusz Biesaga, Albert Escobedo, Lídia Bardia, Xavier Verdaguer, Alessandro Ruffoni, Nasrin R. Mawji, Juan Wang, Teresa Tam, Isabelle Brun-Heath, Salvador Ventura, David Meierhofer, Jesús García, Paul Robustelli, Travis H. Stracker, Marianne D. Sadar, Antoni Riera, Denes Hnisz, and Xavier Salvatella, "Androgen receptor condensates as drug targets", in bioRxiv, (2022).