Publications of Lars Wittler

Journal Article (49)

1.
Journal Article
Huang, X.; Henck, J.; Qiu, C.; Sreenivasan, V. K. A.; Balachandran, S.; Amarie, O. V.; de Angelis, M. H.; Behncke, R. Y.; Chan, W.-L.; Despang, A. et al.; Dickel, D. E.; Duran, M.; Feuchtinger, A.; Fuchs, H.; Gailus-Durner, V.; Haag, N.; Hägerling, R.; Hansmeier, N.; Hennig, F.; Marshall, C.; Rajderkar, S.; Ringel, A.; Robson, M. I.; Saunders, L. M.; da Silva-Buttkus, P.; Spielmann, N.; Srivatsan, S. R.; Ulferts, S.; Wittler, L.; Zhu, Y.; Kalscheuer, V. M.; Ibrahim, D. M.; Kurth, I.; Kornak, U.; Visel, A.; Pennacchio, L. A.; Beier, D. R.; Trapnell, C.; Cao, J.; Shendure, J.; Spielmann, M.: Single-cell, whole-embryo phenotyping of mammalian developmental disorders. Nature 623 (7988), pp. 772 - 781 (2023)
2.
Journal Article
Schifferl, D.; Scholze-Wittler, M.; Villaronga Luque, A.; Pustet , M.; Wittler, L.; Veenvliet, J. V.; Koch, F.: Genome-wide identification of notochord enhancers comprising the regulatory landscape of the Brachyury (T) locus in mouse. Development 150 (22), dev202111 (2023)
3.
Journal Article
Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Limberg, E.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A. et al.; Stötzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 25, pp. 1704 - 1715 (2023)
4.
Journal Article
Sampath Kumar, A.; Tian, L.; Bolondi, A.; Aragonés Hernández, A.; Stickels, R.; Kretzmer, H.; Murray, E.; Wittler, L.; Walther, M.; Barakat, G. et al.; Haut, L.; Elkabetz, Y.; Macosko, E. Z.; Guignard, L.; Chen, F.; Meissner, A.: Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nature Genetics 55 (7), pp. 1176 - 1185 (2023)
5.
Journal Article
Tsaytler, P.; Liu, J.; Blaess, G.; Schifferl, D.; Veenvliet, J. V.; Wittler, L.; Timmermann, B.; Herrmann, B. G.; Koch, F.: BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage. Development, dev.201450 (2023)
6.
Journal Article
Cova, G.; Glaser, J.; Schöpflin, R.; Ali, S.; Prada-Medina, C. A.; Franke, M.; Falcone, R.; Federer, M.; Ponzi, E.; Ficarella, R. et al.; Novara, F.; Wittler, L.; Timmermann, B.; Gentile, M.; Zuffardi, O.; Spielmann, M.; Mundlos, S.: Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3. Nature Communications 14, 1475 (2023)
7.
Journal Article
Schindler, M.; Osterwalder, M.; Harabula, I.; Wittler, L.; Tzika, A. C.; Dechmann, D. K. N.; Vingron, M.; Visel, A.; Haas, S.; Real, F. M.: Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes. Development 150 (17), dev201562 (2023)
8.
Journal Article
Schindler, M.; Osterwalder, M.; Harabula, I.; Wittler, L.; Tzika, A. C.; Dechmann, D.; Vingron, M.; Visel, A.; Haas, S.; Real, F. M.: Co-option of the transcription factor SALL1 in mole ovotestis formation. bioRxiv, 514220 (2022)
9.
Journal Article
Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Glaser, J.; Phan, M. H. Q.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S. A.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M. I.: Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Cell 185 (20), pp. 3689 - 3704 (2022)
10.
Journal Article
Asimi, V.; Sampath Kumar, A.; Niskanen, H.; Riemenschneider, C.; Hetzel, S.; Naderi, J.; Fasching, N.; Popitsch, N.; Du, M.; Kretzmer, H. et al.; Smith, Z. D.; Weigert, R.; Walther, M.; Mamde, S.; Meierhofer, D.; Wittler, L.; Buschow, R.; Timmermann, B.; Cisse, I. I.; Ameres, S. L.; Meissner, A.; Hnisz, D.: Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics 54, pp. 1238 - 1247 (2022)
11.
Journal Article
Zywitza, V.; Rusha, E.; Shaposhnikov, D.; Ruiz-Orera, J.; Telugu, N.; Rishko, V.; Hayashi, M.; Michel, G.; Wittler, L.; Stejskal, J. et al.; Holtze, S.; Göritz, F.; Hermes, R.; Wang, J.; Izsvák, Z.; Colleoni, S.; Lazzari, G.; Galli, C.; Hildebrandt, T. B.; Hayashi, K.; Diecke, S.; Drukker, M.: Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Scientific Reports 12, 3100 (2022)
12.
Journal Article
Pour, M.; Sampath Kumar, A.; Farag, N.; Bolondi, A.; Kretzmer, H.; Walther, M.; Wittler, L.; Meissner, A.; Nachman, I.: Emergence and patterning dynamics of mouse-definitive endoderm. iScience 25 (1), 103556 (2022)
13.
Journal Article
Schifferl, D.; Scholze-Wittler, M.; Wittler, L.; Veenvliet, J. V.; Koch, F.; Herrmann, B. G.: A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development. Development 148 (23), dev200059 (2021)
14.
Journal Article
Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Sampath Kumar, A.; Mattei, A. L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B. et al.; Giehr, P.; Buschow, R.; Galonska, C.; von Meyenn, F.; Pappalardi, M. B.; McCabe, M. T.; Wittler, L.; Giesecke-Thiel, C.; Mielke, T.; Meierhofer, D.; Timmermann, B.; Müller, F.-J.; Walter, J.; Meissner, A.: Dnmt1 has de novo activity targeted to transposable elements. Nature Structural and Molecular Biology 2021 (2021)
15.
Journal Article
Allou, L.; Balzano, S.; Magg, A.; Quinodoz, M.; Royer-Bertrand, B.; Schöpflin, R.; Chan, W.-L.; Speck-Martins, C. E.; Rocha Carvalho, D.; Farage, L. et al.; Marques Lourenço, C.; Albuquerque, R.; Rajagopal, S.; Nampoothiri, S.; Campos-Xavier, B.; Chiesa, C.; Niel-Bütschi, F.; Wittler, L.; Timmermann, B.; Spielmann, M.; Robson, M.; Ringel, A.; Heinrich, V.; Cova, G.; Andrey , G.; Prada-Medina, C. A.; Pescini-Gobert, R.; Unger, S.; Bonafé, L.; Grote, P.; Rivolta, C.; Mundlos, S.; Superti-Furga, A.: Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator. Nature (2021)
16.
Journal Article
de Los Santos, M. R.; Rivalan, M.; David, F. S.; Stumpf, A.; Pitsch, J.; Tsortouktzidis, D.; Moreno Velasquez, L.; Voigt, A.; Schilling, K.; Mattei, D. et al.; Long, M.; Vogt, G.; Knaus, A.; Fischer-Zirnsak, B.; Wittler, L.; Timmermann, B.; Robinson , P. N.; Horn, D.; Mundlos, S.; Kornak, U.; Becker, A. J.; Schmitz , D.; Winter, Y.; Krawitz, P. M.: A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. Proceedings of the National Academy of Sciences of the United States of America 118 (2), e2014481118 (2021)
17.
Journal Article
Veenvliet, J. V.; Bolondi, A.; Kretzmer, H.; Haut, L.; Scholze-Wittler, M.; Schifferl, D.; Koch, F.; Guignard, L.; Sampath Kumar, A.; Pustet, M. et al.; Heimann, S.; Buschow, R.; Wittler, L.; Timmermann, B.; Meissner, A.; Herrmann, B. G.: Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. Science 370 (6522), eaba4937 (2020)
18.
Journal Article
Real, F. M.; Haas, S. A.; Franchini, P.; Xiong, P.; Simakov, O.; Kuhl, H.; Schöpflin, R.; Heller, D.; Moeinzadeh, M. H.; Heinrich, V. et al.; Krannich , T.; Bressin, A.; Hartmann, M. F.; Wudy, S. A.; Dechmann, D. K. N.; Hurtado, A.; Barrionuevo, F. J.; Schindler, M.; Harabula, I.; Osterwalder, M.; Hiller, M.; Wittler, L.; Visel, A.; Timmermann, B.; Meyer, A.; Vingron, M.; Jiménez, R.; Mundlos, S.; Lupiáñez, D. G.: The mole genome reveals regulatory rearrangements associated with adaptive intersexuality. Science 370 (6513), pp. 208 - 214 (2020)
19.
Journal Article
Rieke, J. M.; Zhang, R.; Braun, D.; Yilmaz, Ö.; Japp, A. S.; Lopes, F. M.; Pleschka, M.; Hilger, A. C.; Schneider, S.; Newman, W. G. et al.; Beaman, G. M.; Nordenskjöld, A.; Ebert, A.-K.; Promm, M.; Roesch, W. H.; Stein, R.; Hirsch, K.; Schäfer, F.-M.; Schmiedeke, E.; Boemers, T. M.; Lacher, M.; Kluth, D.; Gosemann, J.-H.; Anderberg, M.; Barker, G.; Holmdahl, G.; Läckgren, G.; Keene, D.; Cervellione, R. M.; Giorgio, E.; Di Grazia, M.; Wouter, F. F. J.; Marcelis, C. L. M.; Van Rooij, I. A. L. M.; Bökenkamp, A.; Beckers, G. M. A.; Keegan, C. E.; Sharma, A.; Chand Dakal, T.; Wittler, L.; Grote, P.; Zwink, N.; Jenetzky, E.; Brusco, A.; Thiele, H.; Ludwig, M.; Schweizer, U.; Woolf, A. S.; Odermatt, B.; Reutter, H.: SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Frontiers in Cell and Developmental Biology 8, 567 (2020)
20.
Journal Article
Grosswendt, S.; Kretzmer, H.; Smith, Z. D.; Sampath Kumar, A.; Hetzel, S.; Wittler, L.; Klages, S.; Timmermann, B.; Mukherji, S.; Meissner, A.: Epigenetic regulator function through mouse gastrulation. Nature 584, pp. 102 - 108 (2020)
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