Publications of Thorsten Mielke

Brandt, R.; Sell, T.; Lüthen, M.; Uhlitz, F.; Klinger, B.; Riemer, P.; Giesecke-Thiel, C.; Schulze, S.; El-Shimy, I. A.; Kunkel, D. et al.; Fauler, B.; Mielke, T.; Mages, N.; Herrmann, B. G.; Sers, C.; Blüthgen, N.; Morkel, M.: Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nature Communications 10 (1), 2919 (2019)

Krupp, F.; Said, N.; Huang, Y.-H.; Loll, B.; Bürger, J.; Mielke, T.; Spahn, C. M.T.; Wahl, M. C.: Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor. Molecular Cell 74 (1), e5, pp. 143 - 157 (2019)

Flis, J.; Holm, M.; Rundlet, E. J.; Loerke, J.; Hilal, T.; Dabrowski, M.; Bürger, J.; Mielke, T.; Blanchard, S. C.; Spahn, C. M.T. et al.; Budkevich, T. V.: tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell Reports 25 (10), e7, pp. 2676 - 2688 (2018)

Qureshi, B. M.; Behrmann, E.; Schöneberg, J.; Loerke, J.; Bürger, J.; Mielke, T.; Giesebrecht, J.; Noé, F.; Lamb, T. D.; Hofmann, K. P. et al.; Spahn, C. M. T.; Heck, M.: It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods. Open Biology 8 (8), 180075 (2018)

Jaworski, P.; Donczew, R.; Mielke, T.; Weigel, C.; Stingl, K.; Zawilak-Pawlik, A.: Structure and function of the Campylobacter jejuni chromosome replication origin. Frontiers in Microbiology 9, 9:1533 (2018)

Nikolay, R.; Hilal, T.; Qin, B.; Mielke, T.; Bürger, J.; Loerke, J.; Textoris-Taube, K.; Nierhaus, K. H.; Spahn, C. M.T.: Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution. Molecular Cell 70 (5), e3, pp. 881 - 893 (2018)

Reddy Devullapally, P.; Bürger, J.; Mielke, T.; Konthur, Z.; Lehrach, H.; Yaspo, M.-L.; Glökler, J.; Warnatz, H.-J.: Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes. Genome Medicine 10, 10:34 (2018)

Qureshi, B. M.; Schmidt, A.; Behrmann, E.; Bürger, J.; Mielke, T.; Spahn, C. M. T.; Heck, M.; Scheerer, P.: Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6. Nature Communications 9 (1), 90 (2018)

Reddy-Alla, S.; Böhme, M. A.; Reynolds, E.; Beis, C.; Grasskamp, A. T.; Mampell, M. M.; Maglione, M.; Jusyte, M.; Rey, U.; Babikir, H. et al.; McCarthy, A. W.; Quentin, C.; Matkovic, T.; Bergeron, D. D.; Mushtaq, Z.; Göttfert, F.; Owald, D.; Mielke, T.; Hell, S. W.; Sigrist, S. J.; Walter, A. M.: Stable positioning of Unc13 restricts synaptic vesicle fusion to defined release sites to promote synchronous neurotransmission. Neuron 95 (6), pp. 1350 - 1364 (2017)

Matz, P.; Wruck, W.; Fauler, B.; Herebian, D.; Mielke, T.; Adjaye, J.: Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks. Scientific Reports 7 (1), 6294 (2017)

Lorenz, C.; Lesimple, P.; Bukowiecki, R.; Zink, A.; Inak, G.; Mlody, B.; Singh, M.; Semtner, M.; Mah, N.; Auré, K. et al.; Leong, M.; Zabiegalov, O.; Lyras, E.-M.; Pfiffer, V.; Fauler, B.; Eichhorst, J.; Wiesner, B.; Huebner, N.; Priller, J.; Mielke, T.; Meierhofer, D.; Izsvák, Z.; Meier, J. C.; Bouillaud, F.; Adjaye, J.; Schuelke, M.; Wanker, E. E.; Lombès, A.; Prigione, A.: Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders. Cell Stem Cell 20 (5), e9, pp. 659 - 674 (2017)

Said, N.; Krupp, F.; Anedchenko, E.; Santos, K. F.; Dybkov, O.; Huang, Y. H.; Lee, C. T.; Loll, B.; Behrmann, E.; Buerger, J. et al.; Mielke, T.; Loerke, J.; Urlaub, H.; Spahn, C. M. T.; Weber, G.; Wahl, M. C.: Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2, 2:17062 (2017)

Hilal, T.; Yamamoto, H.; Loerke, J.; Bürger, J.; Mielke, T.; Spahn, C. M. T.: Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution. Nature Communications 7, 7:13521 (2016)

Arumughan, A.; Roske, Y.; Barth, C.; Forero, L. L.; Bravo-Rodriguez, K.; Redel, A.; Kostova, S.; McShane, E.; Robert Opitz, R.; Faelber, K. et al.; Rau, K.; Mielke, T.; Daumke, O.; Selbach, M.; Sanchez-Garcia, E.; Rocks, O.; Daniela Panáková, D.; Heinemann, U.; Wanker, E. E.: Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nature Communications 7, 7:13047 (2016)

Jaworski, P.; Donczew, R.; Mielke, T.; Thiel, M.; Oldziej, S.; Weigel, C.; Zawilak-Pawlik, A.: Unique and Universal Features of Epsilonproteobacterial Origins of Chromosome Replication and DnaA-DnaA Box Interactions. Frontiers in Microbiology 7, 7:1555 (2016)

Gupta, V. K.; Pech, U.; Bhukel, A.; Fulterer, A.; Ender, A.; Mauermann, S. F.; Andlauer, T. F. M.; Antwi-Adjei, E.; Beuschel, C.; Thriene, K. et al.; Maglione, M.; Quentin, C.; Bushow, R.; Schwaerzel, M.; Mielke, T.; Dengjel, J.; Fiala, A.; Sigrist, S. J.: Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release. PLOS BIOLOGY 14 (9), e1002563 (2016)

Sprink, T.; Ramrath, D. J. F.; Yamamoto, H.; Yamamoto, K.; Loerke, J.; Ismer, J.; Hildebrand, P. W.; Scheerer, P.; Bürger, J.; Mielke, T. et al.; Spahn, C. M. T.: Structures of ribosome-bound initiation factor 2 reveal mechanism of subunit association. Science Advances 2 (3), e1501502 (2016)

Yamamoto, H.; Collier, M.; Loerke, J.; Ismer, J.; Schmidt, A.; Hilal, T.; Sprink, T.; Yamamoto, K.; Mielke, T.; Bürger, J. et al.; Shaikh, T. R.; Dabrowski, M.; Hildebrand, P. W.; Scheerer, P.; Spahn, C. M. T.: Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA. EMBO Journal 34 (24), pp. 3042 - 3058 (2015)

Behrmann, E.; Loerke, J.; Budkevich, T. .; Yamamoto, K.; Schmidt, A.; Penczek, P. .; Vos, M. .; Bürger, J.; Mielke, T.; Scheerer, P. et al.; Spahn, C. . T.: Structural Snapshots of Actively Translating Human Ribosomes. Cell 161 (4), pp. 845 - 857 (2015)

van der Sluis, E. O.; Bauerschmitt, H.; Becker, T.; Mielke, T.; Frauenfeld, J.; Berninghausen, O.; Neupert, W.; Herrmann, J. M.; Beckmann, R.: Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes. Genome biology and evolution 7 (5), pp. 1235 - 1251 (2015)