Publications

Eijken, M.; Krautzberger, A. M.; Scholze-Wittler, M.; Boers-Sijmons, B.; Koedam, M.; Kosiol, B.; Schrewe, H.; van Leeuwen, J. P.; van der Eerden, B. C.: Vasorin-deficient mice display disturbed vitamin D and mineral homeostasis in combination with a low bone mass phenotype. Bone Reports 22, Article 101792 (2024)

MPG.PuRe

Batki, J.; Hetzel, S.; Schifferl, D.; Bolondi, A.; Walther, M.; Wittler, L.; Grosswendt, S.; Herrmann, B. G.; Meissner, A.: Extraembryonic gut endoderm cells undergo programmed cell death during development. Nature Cell Biology 26 (6), pp. 868 - 877 (2024)

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Andrique, C.; Bonnet, A. L.; Dang, J.; Lesieur, J.; Krautzberger, A. M.; Baroukh, B.; Torrens, C.; Sadoine, J.; Schmitt, A.; Rochefort, G. Y. et al.; Bardet, C.; Six, I.; Houillier, P.; Tharaux, P. L.; Schrewe, H.; Gaucher, C.; Chaussain, C.: Vasorin as an actor of bone turnover? Journal of Cellular Physiology 239 (6), Article e31257 (2024)

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Tsaytler, P.; Blaess, G.; Scholze-Wittler, M.; Koch, F.; Herrmann, B. G.: Early neural specification of stem cells is mediated by a set of SOX2-dependent neural-associated enhancers. Stem Cell Reports 19 (5), pp. 618 - 628 (2024)

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2023

Huang, X.; Henck, J.; Qiu, C.; Sreenivasan, V. K. A.; Balachandran, S.; Amarie, O. V.; de Angelis, M. H.; Behncke, R. Y.; Chan, W.-L.; Despang, A. et al.; Dickel, D. E.; Duran, M.; Feuchtinger, A.; Fuchs, H.; Gailus-Durner, V.; Haag, N.; Hägerling, R.; Hansmeier, N.; Hennig, F.; Marshall, C.; Rajderkar, S.; Ringel, A.; Robson, M. I.; Saunders, L. M.; da Silva-Buttkus, P.; Spielmann, N.; Srivatsan, S. R.; Ulferts, S.; Wittler, L.; Zhu, Y.; Kalscheuer, V. M.; Ibrahim, D. M.; Kurth, I.; Kornak, U.; Visel, A.; Pennacchio, L. A.; Beier, D. R.; Trapnell, C.; Cao, J.; Shendure, J.; Spielmann, M.: Single-cell, whole-embryo phenotyping of mammalian developmental disorders. Nature 623 (7988), pp. 772 - 781 (2023)

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Schifferl, D.; Scholze-Wittler, M.; Villaronga Luque, A.; Pustet , M.; Wittler, L.; Veenvliet, J. V.; Koch, F.; Herrmann, B. G.: Genome-wide identification of notochord enhancers comprising the regulatory landscape of the Brachyury (T) locus in mouse. Development 150 (22), dev202111 (2023)

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Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Limberg, E.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A. et al.; Stötzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 25 (11), pp. 1704 - 1715 (2023)

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Sampath Kumar, A.; Tian, L.; Bolondi, A.; Aragonés Hernández, A.; Stickels, R.; Kretzmer, H.; Murray, E.; Wittler, L.; Walther, M.; Barakat, G. et al.; Haut, L.; Elkabetz, Y.; Macosko, E. Z.; Guignard, L.; Chen, F.; Meissner, A.: Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nature Genetics 55 (7), pp. 1176 - 1185 (2023)

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Tsaytler, P.; Liu, J.; Blaess, G.; Schifferl, D.; Veenvliet, J. V.; Wittler, L.; Timmermann, B.; Herrmann, B. G.; Koch, F.: BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage. Development 150 (10), Article dev.201450 (2023)

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Cova, G.; Glaser, J.; Schöpflin, R.; Ali, S.; Prada-Medina, C. A.; Franke, M.; Falcone, R.; Federer, M.; Ponzi, E.; Ficarella, R. et al.; Novara, F.; Wittler, L.; Timmermann, B.; Gentile, M.; Zuffardi, O.; Spielmann, M.; Mundlos, S.: Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3. Nature Communications 14 (1), Article 1475 (2023)

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2022

Schindler, M.; Osterwalder, M.; Harabula, I.; Wittler, L.; Tzika, A. C.; Dechmann, D.; Vingron, M.; Visel, A.; Haas, S.; Real, F. M.: Co-option of the transcription factor SALL1 in mole ovotestis formation. bioRxiv, 514220 (2022)

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pre-print

López-Anguita, N.; Gassaloglu, S. I.; Stötzel, M.; Bolondi, A.; Conkar , D.; Typou, M.; Buschow, R.; Veenvliet, J. V.; Bulut-Karslioglu, A.: Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids. Development 149 (20), dev200679 (2022)

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Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Glaser, J.; Phan, M. H. Q.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S. A.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M. I.: Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Cell 185 (20), pp. 3689 - 3704 (2022)

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Asimi, V.; Sampath Kumar, A.; Niskanen, H.; Riemenschneider, C.; Hetzel, S.; Naderi, J.; Fasching, N.; Popitsch, N.; Du, M.; Kretzmer, H. et al.; Smith, Z. D.; Weigert, R.; Walther, M.; Mamde, S.; Meierhofer, D.; Wittler, L.; Buschow, R.; Timmermann, B.; Cisse, I. I.; Ameres, S. L.; Meissner, A.; Hnisz, D.: Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics 54 (8), pp. 1238 - 1247 (2022)

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Louvet, L.; Lenglet, G.; Krautzberger, A. M.; Mentaverri, R.; Hague, F.; Kowalewski, C.; Mahtal, N.; Lesieur, J.; Bonnet, A.-L.; Andrique, C. et al.; Gaucher, C.; Gomila, C.; Schrewe, H.; Tharaux, P.-L.; Kamel, S.; Chaussain, C.; Six, I.: Vasorin plays a critical role in vascular smooth muscle cells and arterial functions. Journal of Cellular Physiology 237 (10), pp. 3845 - 3859 (2022)

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Amaral, A.: Energy metabolism in mammalian sperm motility. Wiley interdisciplinary reviews: WIREs Mechanisms of Disease 14 (5), e1569 (2022)

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Zywitza, V.; Rusha, E.; Shaposhnikov, D.; Ruiz-Orera, J.; Telugu, N.; Rishko, V.; Hayashi, M.; Michel, G.; Wittler, L.; Stejskal, J. et al.; Holtze, S.; Göritz, F.; Hermes, R.; Wang, J.; Izsvák, Z.; Colleoni, S.; Lazzari, G.; Galli, C.; Hildebrandt, T. B.; Hayashi, K.; Diecke, S.; Drukker, M.: Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Scientific Reports 12 (1), Article 3100 (2022)

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Pour, M.; Sampath Kumar, A.; Farag, N.; Bolondi, A.; Kretzmer, H.; Walther, M.; Wittler, L.; Meissner, A.; Nachman, I.: Emergence and patterning dynamics of mouse-definitive endoderm. iScience 25 (1), 103556 (2022)

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2021

Schifferl, D.; Scholze-Wittler, M.; Wittler, L.; Veenvliet, J. V.; Koch, F.; Herrmann, B. G.: A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development. Development 148 (23), dev200059 (2021)

MPG.PuRe

Huang, T.-W.; Iyer, A. A.; Manalo, J. M.; Woo, J.; Bosquez Huerta, N. A.; McGovern, M. M.; Schrewe, H.; Pereira, F. A.; Groves, A. K.; Ohlemiller, K. K. et al.; Deneen, B.: Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. The Journal of Neuroscience 41 (34), pp. 7171 - 7181 (2021)

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pre-print

Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Sampath Kumar, A.; Mattei, A. L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B. et al.; Giehr, P.; Buschow, R.; Galonska, C.; von Meyenn, F.; Pappalardi, M. B.; McCabe, M. T.; Wittler, L.; Giesecke-Thiel, C.; Mielke, T.; Meierhofer, D.; Timmermann, B.; Müller, F.-J.; Walter, J.; Meissner, A.: Dnmt1 has de novo activity targeted to transposable elements. Nature Structural and Molecular Biology 28 (7), pp. 594 - 603 (2021)

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Bolondi, A.; Haut, L.; Gassaloglu, S. I.; Burton, P.; Kretzmer, H.; Buschow, R.; Meissner, A.; Herrmann, B. G.; Veenvliet, J. V.: Generation of Mouse Pluripotent Stem Cell-derived Trunk-like Structures: An in vitro Model of Post-implantation Embryogenesis. Bio-protocol 11 (11), e4042 (2021)

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Veenvliet, J. V.; Herrmann, B. G.: Modeling mammalian trunk development in a dish. Developmental Biology 474, pp. 5 - 15 (2021)

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Allou, L.; Balzano, S.; Magg, A.; Quinodoz, M.; Royer-Bertrand, B.; Schöpflin, R.; Chan, W.-L.; Speck-Martins, C. E.; Rocha Carvalho, D.; Farage, L. et al.; Marques Lourenço, C.; Albuquerque, R.; Rajagopal, S.; Nampoothiri, S.; Campos-Xavier, B.; Chiesa, C.; Niel-Bütschi, F.; Wittler, L.; Timmermann, B.; Spielmann, M.; Robson, M.; Ringel, A.; Heinrich, V.; Cova, G.; Andrey , G.; Prada-Medina, C. A.; Pescini-Gobert, R.; Unger, S.; Bonafé, L.; Grote, P.; Rivolta, C.; Mundlos, S.; Superti-Furga, A.: Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator. Nature 592 (7852), pp. 93 - 98 (2021)

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Amaral, A.; Herrmann, B. G.: RAC1 controls progressive movement and competitiveness of mammalian spermatozoa. PLoS Genetics 17 (2), e1009308 (2021)

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de Los Santos, M. R.; Rivalan, M.; David, F. S.; Stumpf, A.; Pitsch, J.; Tsortouktzidis, D.; Moreno Velasquez, L.; Voigt, A.; Schilling, K.; Mattei, D. et al.; Long, M.; Vogt, G.; Knaus, A.; Fischer-Zirnsak, B.; Wittler, L.; Timmermann, B.; Robinson , P. N.; Horn, D.; Mundlos, S.; Kornak, U.; Becker, A. J.; Schmitz , D.; Winter, Y.; Krawitz, P. M.: A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. Proceedings of the National Academy of Sciences of the United States of America 118 (2), e2014481118 (2021)

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Farrall, A.; Lienhard, M.; Grimm, C.; Kuhl, H.; Sluka, S. H. M.; Caparros Rodriguez, M.; Forejt, J.; Timmermann, B.; Herwig, R.; Herrmann, B. G. et al.; Morkel, M.: PWD/Ph-encoded genetic variants modulate the cellular Wnt/β-Catenin response to suppress ApcMin-triggered intestinal tumor formation. Cancer research: an official organ of the American Association for Cancer Research 81 (1), pp. 38 - 49 (2021)

MPG.PuRe

2020

Veenvliet, J. V.; Bolondi, A.; Kretzmer, H.; Haut, L.; Scholze-Wittler, M.; Schifferl, D.; Koch, F.; Guignard, L.; Sampath Kumar, A.; Pustet, M. et al.; Heimann, S.; Buschow, R.; Wittler, L.; Timmermann, B.; Meissner, A.; Herrmann, B. G.: Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. Science 370 (6522), eaba4937 (2020)

MPG.PuRe

Real, F. M.; Haas, S. A.; Franchini, P.; Xiong, P.; Simakov, O.; Kuhl, H.; Schöpflin, R.; Heller, D.; Moeinzadeh, M. H.; Heinrich, V. et al.; Krannich , T.; Bressin, A.; Hartmann, M. F.; Wudy, S. A.; Dechmann, D. K. N.; Hurtado, A.; Barrionuevo, F. J.; Schindler, M.; Harabula, I.; Osterwalder, M.; Hiller, M.; Wittler, L.; Visel, A.; Timmermann, B.; Meyer, A.; Vingron, M.; Jiménez, R.; Mundlos, S.; Lupiáñez, D. G.: The mole genome reveals regulatory rearrangements associated with adaptive intersexuality. Science 370 (6513), pp. 208 - 214 (2020)

MPG.PuRe

Rieke, J. M.; Zhang, R.; Braun, D.; Yilmaz, Ö.; Japp, A. S.; Lopes, F. M.; Pleschka, M.; Hilger, A. C.; Schneider, S.; Newman, W. G. et al.; Beaman, G. M.; Nordenskjöld, A.; Ebert, A.-K.; Promm, M.; Roesch, W. H.; Stein, R.; Hirsch, K.; Schäfer, F.-M.; Schmiedeke, E.; Boemers, T. M.; Lacher, M.; Kluth, D.; Gosemann, J.-H.; Anderberg, M.; Barker, G.; Holmdahl, G.; Läckgren, G.; Keene, D.; Cervellione, R. M.; Giorgio, E.; Di Grazia, M.; Wouter, F. F. J.; Marcelis, C. L. M.; Van Rooij, I. A. L. M.; Bökenkamp, A.; Beckers, G. M. A.; Keegan, C. E.; Sharma, A.; Chand Dakal, T.; Wittler, L.; Grote, P.; Zwink, N.; Jenetzky, E.; Brusco, A.; Thiele, H.; Ludwig, M.; Schweizer, U.; Woolf, A. S.; Odermatt, B.; Reutter, H.: SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Frontiers in Cell and Developmental Biology 8, 567 (2020)

MPG.PuRe

Grosswendt, S.; Kretzmer, H.; Smith, Z. D.; Sampath Kumar, A.; Hetzel, S.; Wittler, L.; Klages, S.; Timmermann, B.; Mukherji, S.; Meissner, A.: Epigenetic regulator function through mouse gastrulation. Nature 584 (7819), pp. 102 - 108 (2020)

MPG.PuRe

2019

Segal, J.; Mülleder, M.; Krüger, A.; Adler, T.; Scholze-Wittler, M.; Becker, L.; Calzada-Wack, J.; Garrett, L.; Hölter, S. M.; Rathkolb, B. et al.; Rozman, J.; Racz, I.; Fischer, R.; Busch, D. H.; Neff, F.; Klingenspor, M.; Klopstock, T.; Grüning, N.-M.; Michel, S.; Lukaszewska-McGreal, B.; Voigt, I.; Hartmann, L.; Timmermann, B.; Lehrach, H.; Wolf, E.; Wurst, W.; Gailus-Durner, V.; Fuchs, H.; de Angelis, M. H.; Schrewe, H.; Yuneva, M.; Ralser, M.: Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency. Journal of Inherited Metabolic Disease 22 (5), pp. 839 - 849 (2019)

MPG.PuRe

Despang, A.; Schöpflin, R.; Franke, M.; Ali, S.; Jerković, I.; Paliou, C.; Chan, W.-L.; Timmermann, B.; Wittler, L.; Vingron, M. et al.; Mundlos, S.; Ibrahim, D. M.: Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture. Nature Genetics 51 (8), pp. 1263 - 1271 (2019)

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Brandt, R.; Sell, T.; Lüthen, M.; Uhlitz, F.; Klinger, B.; Riemer, P.; Giesecke-Thiel, C.; Schulze, S.; El-Shimy, I. A.; Kunkel, D. et al.; Fauler, B.; Mielke, T.; Mages, N.; Herrmann, B. G.; Sers, C.; Blüthgen, N.; Morkel, M.: Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nature Communications 10 (1), 2919 (2019)

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Paliou, C.; Guckelberger, P.; Schöpflin, R.; Heinrich, V.; Esposito, A.; Chiariello, A. M.; Bianco, S.; Annunziatella, C.; Helmuth, J.; Haas, S. et al.; Jerković, I.; Brieske, N.; Wittler, L.; Timmermann, B.; Nicodemi, M.; Vingron, M.; Mundlos, S.; Andrey, G.: Preformed Chromatin Topology Assists Transcriptional Robustness of Shh during Limb Development. Proceedings of the National Academy of Sciences of the United States of America 116 (25), pp. 12390 - 12399 (2019)

MPG.PuRe

supplementary-material

Kraft, K.; Magg, A.; Heinrich, V.; Riemenschneider, C.; Schöpflin, R.; Markowski, J.; Ibrahim, D.; Acuna-Hidalgo, R.; Despang, A.; Andrey, G. et al.; Wittler, L.; Timmermann, B.; Vingron, M.; Mundlos, S.: Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations. Nature Cell Biology 21 (3), pp. 305 - 310 (2019)

MPG.PuRe

Charron, Y.; Willert, J.; Lipkowitz, B.; Kusecek, B.; Herrmann, B. G.; Bauer, H.: Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype. PLOS Genetics 15 (2), e1007964 (2019)

MPG.PuRe

Kahrizi, K.; Hu, H.; Hosseini, M.; Kalscheuer, V. M.; Fattahi, Z.; Beheshtian, M.; Suckow, V.; Mohseni, M.; Lipkowitz, B.; Mehvari, S. et al.; Mehrjoo, Z.; Akhtarkhavari, T.; Ghaderi, Z.; Rahimi, M.; Arzhangi, S.; Jamali, P.; Falahat Chian, M.; Nikuei , P.; Sabbagh Kermani, F.; Sadeghinia, F.; Jazayeri , R.; Tonekaboni, S. H.; Khoshaeen, A.; Habibi, H.; Pourfatemi, F.; Mojahedi , F.; Khodaie‐Ardakani, M.; Najafipour, R.; Wienker, T. F.; Najmabadi , H.; Ropers, H.-H.: Effect of inbreeding on intellectual disability revisited by Trio sequencing. Clinical Genetics: an international journal of genetics in medicine 95 (1), pp. 151 - 159 (2019)

MPG.PuRe

2018

Kragesteen , B. K.; Spielmann, M.; Paliou, C.; Heinrich, V.; Schöpflin, R.; Esposito, A.; Annunziatella, C.; Bianco , S.; Chiariello, A. M.; Jerković , I. et al.; Harabula, I.; Guckelberger, P.; Pechstein, M.; Wittler, L.; Chan, W.-L.; Franke, M.; Lupiáñez , D. G.; Kraft, K.; Timmermann, B.; Vingron, M.; Visel, A.; Nicodemi, M.; Mundlos, S.; Andrey, G.: Dynamic 3D chromatin architecture determines enhancer specificity and morphogenetic identity in limb development. Nature Genetics 50 (10), pp. 1463 - 1473 (2018)

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supplementary-material

Flöttmann, R.; Kragesteen, B. K.; Geuer, S.; Socha, M.; Allou, L.; Sowińska-Seidler, A.; Bosquillon de Jarcy, L.; Wagner, J.; Jamsheer, A.; Oehl-Jaschkowitz, B. et al.; Wittler, L.; de Silva, D.; Kurth, I.; Maya, I.; Santos-Simarro, F.; Hülsemann, W.; Klopocki, E.; Mountford, R.; Fryer, A.; Borck, G.; Horn, D.; Lapunzina, P.; Wilson, M.; Mascrez, B.; Duboule, D.; Mundlos, S.; Spielmann, M.: Noncoding copy-number variations are associated with congenital limb malformation. GENETICS IN MEDICINE 20 (6), pp. 599 - 607 (2018)

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Bianco, S.; Lupiáñez, D. G.; Chiariello, A. M.; Annunziatella, C.; Kraft, K.; Schöpflin, R.; Wittler, L.; Andrey, G.; Vingron, M.; Pombo, A. et al.; Mundlos, S.; Nicodemi, M.: Polymer physics predicts the effects of structural variants on chromatin architecture. Nature Genetics 50 (5), pp. 662 - 667 (2018)

MPG.PuRe

Weitensteiner, V.; Zhang, R.; Bungenberg, J.; Marks, M.; Gehlen, J.; Ralser, D. J.; Hilger, A. C.; Sharma, A.; Schumacher , J.; Gembruch, U. et al.; Merz, W. M.; Becker, A.; Altmüller, J.; Thiele, H.; Herrmann, B. G.; Odermatt , B.; Ludwig, M.; Reutter, H.: Exome sequencing in syndromic brain malformations identifies novel mutations in ACTB, and SLC9A6, and suggests BAZ1A as a new candidate gene. Birth Defects Research 110 (7), pp. 587 - 597 (2018)

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Beisaw, A.; Tsaytler, P.; Koch, F.; Schmitz, S. U.; Melissari, M.-T.; Senf, A. D.; Wittler, L.; Pennimpede, T.; Macura, K.; Herrmann, B. G. et al.; Grote, P.: BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Reports 19 (1), pp. 118 - 134 (2018)

MPG.PuRe

2017

Will , A. J.; Cova, G.; Osterwalder, M.; Chan, W. L.; Wittler, L.; Brieske, N.; Heinrich, V.; de Villartay, J. P.; Vingron, M.; Klopocki, E. et al.; Visel, A.; Lupianez, D. G.; Mundlos, S.: Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog). Nature Genetics 49 (10), pp. 1539 - 1545 (2017)

MPG.PuRe

Koch, F.; Scholze, M.; Wittler, L.; Schifferl, D.; Sudheer, S.; Grote, P.; Timmermann, B.; Macura, K.; Herrmann, B. G.: Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Developmental Cell 42, pp. 514 - 526 (2017)

MPG.PuRe

Baskin, K. K.; Makarewich, C. A.; DeLeon, S. M.; Ye, W.; Chen, B.; Beetz, N.; Schrewe, H.; Bassel-Duby, R.; Olson, E. N.: MED12 regulates a transcriptional network of calcium-handling genes in the heart. JCI Insight 2 (14), e91920 (2017)

MPG.PuRe

Lange, L.; Marks, M.; Liu, J.; Wittler, L.; Bauer, H.; Piehl, S.; Bläß, G.; Timmermann, B.; Herrmann, B. G.: Pattering and gastrulation deffects caused by the tw18 lethal are due to loss of Ppp2r1a. Biology Open 6 (6), pp. 752 - 764 (2017)

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Riemer, P.; Rydenfelt, M.; Marks, M.; van Eunen, K.; Thedieck, K.; Herrmann, B. G.; Blüthgen, N.; Sers, C.; Morkel, M.: Oncogenic ß-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids. The Journal of Cell Biology: JCB 216 (6), pp. 1567 - 1577 (2017)

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Cauchy, P.; Koch, F.; Andrau, J.-C.: Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP at nucleosome-occupied enhancers. Transcription 8 (3), pp. 179 - 184 (2017)

MPG.PuRe

2016

Franke, M.; Ibrahim, D.; Andrey, G.; Schwarzer, W.; Heinrich, V.; Schöpflin, R.; Kraft, K.; Kempfer, R.; Jerković, I.; Chan, W.-L. et al.; Spielmann, M.; Timmermann, B.; Wittler, L.; Kurth, I.; Cambiaso, P.; Zuffardi, O.; Houge, G.; Lambie, L.; Brancati, F.; Pombo, A.; Vingron, M.; Spitz, F.; Mundlos, S.: Formation of novel chromatin domains determines pathogenicity of genomic duplications. Nature 538 (7624), pp. 265 - 269 (2016)

MPG.PuRe

Vermeren, M. M.; Zhang, Q.; Smethurst, E.; Segonds-Pichon, A.; Schrewe, H.; Wakelam, M. J. O.: The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia. PLoS One 11 (9), e0162814 (2016)

MPG.PuRe

Fenouil, R.; Descostes, N.; Spinelli, .; Koch, F.; Maqbool, M. A.; Benoukraf, T.; Cauchy, P.; Innocenti , C.; Ferrier , P.; Andrau, J.-C.: Pasha: a versatile R package for piling chromatin HTS data. Bioinformatics 32 (16), pp. 2528 - 2530 (2016)

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Schmitz, S. U.; Grote, P.; Herrmann, B. G.: Mechanisms of long noncoding RNA function in development and disease. Cellular and Molecular Life Sciences 73 (13), pp. 2491 - 2509 (2016)

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Sudheer, S.; Liu, J.; Marks, M.; Koch, F.; Anurin, A.; Scholze, M.; Senft, A. D.; Wittler, L.; Macura, K.; Grote, P. et al.; Herrmann, B. G.: Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm. Stem Cells 34 (7), pp. 1790 - 800 (2016)

MPG.PuRe

Veenvliet, J. V.: Studying Mesodiencephalic Dopaminergic Neuron Development In Vivo to Improve Stem Cell Therapy in Parkinson’s Disease. The Journal of Neuroscience 36 (6), pp. 1794 - 1796 (2016)

MPG.PuRe

Spielmann, M.; Kakar, N.; Tayebi, N.; Leettola, C.; Nürnberg, G.; Sowada, N.; Lupiáñez, D. G.; Harabula, I.; Flöttmann, R.; Horn, D. et al.; Chan, W. L.; Wittler, L.; Yilmaz, R.; Altmüller, J.; Thiele, H.; van Bokhoven,, H.; Schwartz, C. E.; Nürnberg, P.; Bowie, J. U.; Ahmad, J.; Kubisch, C.; Mundlos, S.: Exome Sequencing and CRISPR/Cas Genome Editing Identify Mutations of ZAK as a Cause of Limb Defects in Humans and Mice. Genome Research 26 (2), pp. 183 - 191 (2016)

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Marks, M.; Pennimpede, T.; Lange, L.; Grote, P.; Herrmann, B. G.; Wittler, L.: Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene 575 (2 Pt 2), pp. 438 - 451 (2016)

MPG.PuRe

2015

Grote, P.; Herrmann, B. G.: Long noncoding RNAs in organogenesis: Making the difference. Trends in Genetics 31 (6), pp. 329 - 335 (2015)

MPG.PuRe

Lupiáñez, D. G.; Kraft, K.; Heinrich, V.; Krawitz, P.; Brancati, F.; Klopocki, E.; Horn, D.; Kayserili, H.; Opitz, J. M.; Laxova, R. et al.; Santos-Simarro, F.; Gilbert-Dussardier, B.; Wittler, L.; Borschiwer, M.; Haas, S. A.; Osterwalder, M.; Franke, M.; Timmermann, B.; Hecht, J.; Spielmann, M.; Visel, A.; Mundlos, S.: Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions. Cell 161 (5), pp. 1012 - 1025 (2015)

MPG.PuRe

Milenkovic, A.; Brandl, C.; Milenkovic, V. M.; Jendryke, T.; Sirianant, L.; Wanitchakool, P.; Zimmermann, S.; Reiff, C. M.; Horling, F.; Schrewe, H. et al.; Schreiber, R.; Kunzelmann, K.; Wetzel, C. H.; Weber, B. H. F.: Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells. Proceedings of the National Academy of Sciences of the United States of America 112 (20), pp. E2630 - E2639 (2015)

MPG.PuRe

Kraft, K.; Geuer, S.; Will, A. J.; Chan, W. L.; Paliou, C.; Borschiwer, M.; Harabula, I.; Wittler, L.; Franke, M.; Ibrahim, D. et al.; Kragesteen, B. K.; Spielmann, M.; Mundlos, S.; Lupianez, D. G.; Andrey, G.: Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice. Cell Reports 10 (5), pp. 833 - 839 (2015)

MPG.PuRe

2014

Scherthan, H.; Schöfisch, K.; Dell, T.; Illner, D.: Contrasting behavior of heterochromatic and euchromatic chromosome portions and pericentric genome separation in pre-bouquet spermatocytes of hybrid mice. Chromosoma: Biology of the Nucleus 123 (6), pp. 609 - 624 (2014)

MPG.PuRe

Rudat, C.; Grieskamp, T.; Röhr, C.; Airik, R.; Wrede, C.; Hegermann, J.; Herrmann, B. G.; Schuster-Gossler, K.; Kispert, A.: Upk3b is dispensable for development and integrity of urothelium and mesothelium. PLoS One 9 (11), e112112 (2014)

MPG.PuRe

Reutter, H.; Draaken, M.; Pennimpede, T.; Wittler, L.; Brockschmidt, F. F.; Ebert, A. K.; Bartels, E.; Rösch, W.; Boemers, T. M.; Hirsch, K. et al.; Schmiedeke, E.; Meesters, C.; Becker, T.; Stein, R.; Utsch, B.; Mangold, E.; Nordenskjöld, A.; Barker, G.; Kockum, C. C.; Zwink, N.; Homdahl, G.; Läckgren, G.; Jenetzky, E.; Feitz, W. F.; Marcelis, C.; Wijers, C. H.; Van Rooij, I. A.; Gearhart, J. P.; Herrmann, B. G.; Ludwig, M.; Boyadjiev, S. A.; Nöthen, M. M.; Mattheisen, M.: Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder. Human Molecular Genetics 23 (20), pp. 5536 - 5544 (2014)

MPG.PuRe

Liu, J.; Wang, X.; Li, J.; Wang, H.; Wei, G.; Yan, J.: Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain. PLoS Computational Biology 10 (10), e1003884 (2014)

MPG.PuRe

Liao, J.; Jijon, H. B.; Kim, I. R.; Goel, G.; Doan, A.; Sokol, H.; Bauer, H.; Herrmann, B. G.; Lassen, K. G.; Xavier, R. J.: An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse. PLoS One 9 (9), e108777 (2014)

MPG.PuRe

Kumar, V.; Cheng, S.-C.; Johnson, M. D.; Smeekens, S.; Wojtowicz, A.; Giamarellos-Bourboulis, E.; Karjalainen, J.; Franke, L.; Withoff, S.; Plantinga, T. S. et al.; van de Veerdonk, F.; van der Meer, J.; Joosten, L. A. B.; Sokol, H.; Bauer, H.; Herrmann, B. G.; Bochud, P.-Y.; Marchetti, O.; Perfect, J. R.; Xavier, R.; Kullberg, B. J.; Wijmenga, C.; Netea, M.: Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nature Communications 5, Article 4675 (2014)

MPG.PuRe

Carrell, D. T.; Rajpert-De Meyts, E.; Krausz, C.; Jannini, E. A.; Liu, P. Y.; Gerton, G. L.; La Salle, S.; Amaral, A.: The need of continuous focus on improved mentoring of trainees and young investigators in the field of andrology: highlights of current programs and opportunities for the future. Andrology 2 (5), pp. 649 - 651 (2014)

MPG.PuRe

Riemer, P.; Sreekumar, A.; Reinke, S.; Rad, R.; Schäfer, R.; Sers, C.; Bläker, H.; Herrmann, B. G.; Morkel, M.: Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-Catenin activity. Oncogene 2014, pp. 1 - 12 (2014)

MPG.PuRe

Schwartz, B.; Marks, M.; Wittler, L.; Werber, M.; Währisch, S.; Nordheim, A.; Herrmann, B. G.; Grote, P.: SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mechanisms of Development 133, pp. 23 - 35 (2014)

MPG.PuRe

Draaken, M.; Baudisch, F.; Timmermann, B.; Kuhl, H.; Kerick, M.; Proske, J.; Wittler, L.; Pennimpede, T.; Ebert, A. K.; Rösch, W. et al.; Stein, R.; Bartels, E.; von Lowtzow, C.; Boemers, T. M.; Herms, S.; Gearhart, J. P.; Lakshmanan, Y.; Kockum, C. C.; Holmdahl, G.; Läckgren, G.; Nordenskjöld, A.; Boyadjiev, S. A.; Herrmann, B. G.; Nöthen, M. M.; Ludwig, M.; Reutter, H.: Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region. Birth Defects Research Part A: Clinical and Molecular Teratology 100 (6), pp. 512 - 517 (2014)

MPG.PuRe

Saisawat, P.; Kohl, S.; Hilger, A. C.; Hwang, D.-Y.; Gee, H. Y.; Dworschak, G. C.; Tasic, V.; Pennimpede, T.; Natarajan, S.; Sperry, E. et al.; Matassa, D. S.; Stajic, N.; Bogdanovic, R.; de Blaauw, I.; Marcelis, C. L. M.; Wijers, C. H. W.; Bartels, E.; Schmiedeke, E.; Schmidt, D.; Märzheuser, S.; Grasshoff-Derr, S.; Holland-Cunz, S.; Ludwig, M.; Nöthen, M. M.; Draaken, M.; Brosens, E.; Heij, H.; Tibboel, D.; Hermann, B. G.; Solomon, B. D.; de Klein, A.; van Rooij, I. A. L. M.; Esposito, F.; Reutter, H. M.; Hildebrandt, F.: Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association. Kidney International 85 (6), pp. 1310 - 1317 (2014)

MPG.PuRe

Werber, M.; Wittler, L.; Timmermann, B.; Grote, P.; Herrmann, B. G.: The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development 141 (11), pp. 2325 - 2330 (2014)

MPG.PuRe

Descostes, N.; Heidemann, M.; Spinelli, L.; Schüller, R.; Maqbool, M. A.; Fenouil, R.; Koch, F.; Innocenti, C.; Gut, M.; Gut, I. et al.; Eick, D.; Andrau, J.-C.: Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells. eLife 3, e02105 (2014)

MPG.PuRe

Müller, D.; Cherukuri, P.; Henningfeld, K.; Poh, C. H.; Wittler, L.; Grote, P.; Schlüter, O.; Schmidt, J.; Laborda, J.; Bauer, S. R. et al.; Brownstone, R. M.; Marquardt, T.: Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution. Science 343 (6176), pp. 1264 - 1266 (2014)

MPG.PuRe

Vucicevic, D.; Schrewe, H.; Ørom, U. A.: Molecular mechanisms of long ncRNAs in neurological disorders. Frontiers in Genetics 5, 5:48 (2014)

MPG.PuRe

Lienhard, M.; Grimm, C.; Morkel, M.; Herwig, R.; Chavez, L.: MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments. Bioinformatics 30 (2), pp. 284 - 286 (2014)

MPG.PuRe

ZIP

Lienhard, M.; Grimm, C.; Morkel, M.; Herwig, R.; Chavez, L.: MEDIPS: genome wide differential coverage analysis of sequencing data derived from DNA enrichment experiments. Bioinformatics 30 (2), pp. 284 - 286 (2014)

MPG.PuRe

Lienhard, M.; Grimm, C.; Morkel, M.; Herwig, R.; Chavez, L.: MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments. Bioinformatics 30 (2), pp. 284 - 286 (2014)

MPG.PuRe

2013

Hilger, A.; Schramm, C.; Pennimpede, T.; Wittler, L.; Dworschak, G. C.; Bartels, E.; Engels, H.; Zink, A. M.; Degenhardt, F.; Müller, A. M. et al.; Schmiedeke, E.; Grasshoff-Derr , S.; Märzheuser, S.; Hosie, S.; Holland-Cunz , S.; Wijers, C. H.; Marcelis, C. L.; van Rooij , I. A.; Hildebrandt, F.; Hermann, B. G.; Nöthen, M. M.; Ludwig, M.; Reutter, H.; Draaken, M.: De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER/VACTERL association. European journal of human genetics: EJHG ; the official journal of the European Society of Human Genetics 21 (12), pp. 1377 - 1382 (2013)

MPG.PuRe

Grote, P.; Herrmann, B. G.: The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. RNA Biology 10 (10), pp. 1579 - 1585 (2013)

MPG.PuRe

Vogl, M. R.; Reiprich, S.; Küspert, M.; Kosian, T.; Schrewe, H.; Nave, K.-A.; Wegner, M.: Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 33 (15), pp. 6679 - 6690 (2013)

MPG.PuRe

Draaken, M.; Mughal, S. S.; Pennimpede, T.; Wolter, S.; Wittler, L.; Ebert, A.-K.; Rösch, W.; Stein, R.; Bartels, E.; Schmidt, D. et al.; Boemers, T. M.; Schmiedeke, E.; Hoffmann, P.; Moebus, S.; Herrmann, B. G.; Nöthen, M. M.; Reutter, H.; Ludwig, M.: Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12. Birth Defects Research, Part A: Clinical and Molecular Teratology 97 (3), pp. 133 - 139 (2013)

MPG.PuRe

Grimm, C.; Chavez, L.; Vilardell, M.; Farrall, A.; Tierling, S.; Böhm, J. W.; Grote, P.; Lienhard, M.; Dietrich, J.; Timmermann, B. et al.; Walter, J.; Schweiger, M. R.; Lehrach, H.; Herwig, R.; Herrmann, B. G.; Morkel, M.: DNA–Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer. PLoS Genetics 9 (2), p. e1003250 - e1003250 (2013)

MPG.PuRe

Grote, P.; Wittler, L.; Hendrix, D.; Währisch, S.; Beisaw, A.; Macura, K.; Bläss, G.; Kellis, M.; Werber, M.; Herrmann, B. G.: The tissue-specific IncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Developmental Cell 24 (2), pp. 206 - 214 (2013)

MPG.PuRe

Krüger, A.; Vowinckel, J.; Mulleder, M.; Grote, P.; Capuano, F.; Bluemlein, K.; Ralser, M.: Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response. EMBO Reports 14 (12), pp. 1113 - 9 (2013)

MPG.PuRe

2012

Pennimpede, T.; Proske, J.; Koenig, A.; Vidigal, J. A.; Morkel, M.; Bramsen, J. B.; Herrmann, B. G.; Wittler, L.: In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome. Developmental Biology 372 (1), pp. 55 - 67 (2012)

MPG.PuRe

Farrall, A.; Riemer, P.; Leushacke, M.; Sreekumar, A.; Grimm, C.; Hermann, B. G.; Morkel, M.: Wnt and BMP signals control intestinal adenoma cell fates. International Journal of Cancer 131 (10), pp. 2242 - 2252 (2012)

MPG.PuRe

Sudheer, S.; Bhushan, R.; Fauler, B.; Lehrach, H.; Adjaye, J.: FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. Stem Cells and Development 21 (16), pp. 2987 - 3000 (2012)

MPG.PuRe

Geffers, L.; Herrmann, B. G.; Eichele, G.: Web-based digital gene expression atlases for the mouse. Mammalian Genome 23, pp. 525 - 538 (2012)

MPG.PuRe

Kämpjärvi, K.; Mäkinen, N.; Kilpivaara, O.; Arola, J.; Heinonen, H.-R.; Böhm, J.; Abdel-Wahab, O.; Lehtonen, H. J.; Pelttari, L. M.; Mehine, M. et al.; Schrewe, H.; Nevanlinna, H.; Levine, R. L.; Hokland, P.; Böhling, T.; Mecklin, J.-P.; Bützow, R.; Aaltonen, L. A.; Vahteristo, P.: Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. British Journal of Cancer 107, pp. 1761 - 1765 (2012)

MPG.PuRe

Wittler, L.; Hilger, A.; Proske, J.; Pennimpede, T.; Draaken, M.; Ebert, A.-K.; Rösch, W.; Stein, R.; Nöthen, M. M.; Reutter, H. et al.; Ludwig, M.: Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias. Gene 506 (2), pp. 392 - 395 (2012)

MPG.PuRe

Krautzberger, M. K.; Kosiol, B.; Scholze, M.; Schrewe, H.: Expression of vasorin (Vasn) during embryonic development of the mouse. Gene Expression Patterns 12 (5-6), pp. 167 - 171 (2012)

MPG.PuRe

Kammerer, R.; Rüttiger, L.; Riesenberg, R.; Schäuble, C.; Krupar, R.; Kamp, A.; Sunami, K.; Eisenried, A.; Hennenberg, M.; Grunert, F. et al.; Breß, A.; Battaglia, S.; Schrewe, H.; Knipper, M.; Schneider, M. R.: Loss of the mammal-specific tectorial membrane component CEA cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. Journal of Biological Chemistry 287, pp. 21584 - 21598 (2012)

MPG.PuRe

Bauer, H.; Schindler, S.; Charon, Y.; Willert, J.; Kusecek, B.; Herrmann, B. G.: The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. PLoS Genetics 8 (3), Article e1002567 (2012)

MPG.PuRe

Schwaerzer, G. K.; Hiepen, C.; Schrewe, H.; Nickel, J.; Ploeger, F.; Sebald, W.; Mueller, T.; Knaus, P.: New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. Journal of Bone and Mineral Research 27 (2), pp. 429 - 442 (2012)

MPG.PuRe

Herrmann, B. G.; Bauer, H.: The mouse t-haplotype: a selfish chromosome-genetics molecular mechanism and evollution. In: Evolution of the House Mouse, 1st edition Ed., pp. 297 - 314 (Ed. Macholán , M.). Cambridge University Press, Cambridge, UK (2012)

MPG.PuRe

2011

Diaz-Lacava, A.; Walier, M.; Penacino, G.; Wienker, T. F.; Baur, M. P.: Spatial assessment of Argentinean genetic admixture with geographical information systems. Forensic Sci Int Genet 5 (4), pp. 297 - 302 (2011)

MPG.PuRe