Publications of Lars Wittler

Schwartz, B.; Marks, M.; Wittler, L.; Werber, M.; Währisch, S.; Nordheim, A.; Herrmann, B. G.; Grote, P.: SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mechanisms of Development 133, pp. 23 - 35 (2014)

Draaken, M.; Baudisch, F.; Timmermann, B.; Kuhl, H.; Kerick, M.; Proske, J.; Wittler, L.; Pennimpede, T.; Ebert, A. K.; Rösch, W. et al.; Stein, R.; Bartels, E.; von Lowtzow, C.; Boemers, T. M.; Herms, S.; Gearhart, J. P.; Lakshmanan, Y.; Kockum, C. C.; Holmdahl, G.; Läckgren, G.; Nordenskjöld, A.; Boyadjiev, S. A.; Herrmann, B. G.; Nöthen, M. M.; Ludwig, M.; Reutter, H.: Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region. Birth Defects Research Part A: Clinical and Molecular Teratology 100 (6), pp. 512 - 517 (2014)

Werber, M.; Wittler, L.; Timmermann, B.; Grote, P.; Herrmann, B. G.: The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development 141 (11), pp. 2325 - 2330 (2014)

Müller, D.; Cherukuri, P.; Henningfeld, K.; Poh, C. H.; Wittler, L.; Grote, P.; Schlüter, O.; Schmidt, J.; Laborda, J.; Bauer, S. R. et al.; Brownstone, R. M.; Marquardt, T.: Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution. Science 343 (6176), pp. 1264 - 1266 (2014)

Hilger, A.; Schramm, C.; Pennimpede, T.; Wittler, L.; Dworschak, G. C.; Bartels, E.; Engels, H.; Zink, A. M.; Degenhardt, F.; Müller, A. M. et al.; Schmiedeke, E.; Grasshoff-Derr , S.; Märzheuser, S.; Hosie, S.; Holland-Cunz , S.; Wijers, C. H.; Marcelis, C. L.; van Rooij , I. A.; Hildebrandt, F.; Hermann, B. G.; Nöthen, M. M.; Ludwig, M.; Reutter, H.; Draaken, M.: De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER/VACTERL association. European journal of human genetics: EJHG ; the official journal of the European Society of Human Genetics 21 (12), pp. 1377 - 1382 (2013)

Grote, P.; Wittler, L.; Hendrix, D.; Währisch, S.; Beisaw, A.; Macura, K.; Bläss, G.; Kellis, M.; Werber, M.; Herrmann, B. G.: The tissue-specific IncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Developmental Cell 24 (2), pp. 206 - 214 (2013)

Pennimpede, T.; Proske, J.; Koenig, A.; Vidigal, J. A.; Morkel, M.; Bramsen, J. B.; Herrmann, B. G.; Wittler, L.: In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome. Developmental Biology 372 (1), pp. 55 - 67 (2012)

Spielmann, M.; Brancati, F.; Krawitz, P. M.; Robinson, P. N.; Ibrahim, D. M.; Franke, M.; Hecht, J.; Lohan, S.; Dathe, K.; Nardone, A. M. et al.; Ferrari, P.; Landi, A.; Wittler, L.; Timmermann, B.; Chan, D.; Mennen, U.; Klopocki, E.; Mundlos, S.: Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus. American Journal of Human Genetics 91 (4), pp. 629 - 635 (2012)

Wittler, L.; Hilger, A.; Proske, J.; Pennimpede, T.; Draaken, M.; Ebert, A.-K.; Rösch, W.; Stein, R.; Nöthen, M. M.; Reutter, H. et al.; Ludwig, M.: Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias. Gene 506 (2), pp. 392 - 395 (2012)

Qi, L.; Chen, K.; Hur, D. J.; Yagnik, G.; Lakshmanan, Y.; Kotch, L. E.; Ashrafi, G. H.; Martinez-Murillo, F.; Kowalski, J.; Naydenov, C. et al.; Wittler, L.; Gearhart, J. P.; Draaken, M.; Reutter, H.; Ludwig, M.; Boyadjiev, S. A.: Genome-wide expression profiling of urinary bladder implicates desmosomal and cytoskeletal dysregulation in the bladder exstrophy-epispadias complex. International Journal of Molecular Medicine 27 (6), pp. 755 - 65 (2011)

Vidigal, J. A.; Morkel, M.; Wittler, L.; Brouwer-Lehmitz, A.; Grote, P.; Macura, K.; Herrmann, B. G.: An inducible RNA interference system for the functional dissection of mouse embryogenesis. Nucleic Acids Research 38 (11), p. e122 - e122 (2010)

Wittler, L.; Shin, E.-h.; Grote, P.; Kispert, A.; Beckers, A.; Gossler, A.; Werber, M.; Herrmann, B. G.: Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Reports 8 (8), pp. 784 - 789 (2007)

Glaser, J.; Cova, G.; Fauler, B.; Prada-Medina, C. A.; Stanislas, V.; Phan, M. H. Q.; Schöpflin, R.; Aktas, Y.; Franke, M.; Andrey, G. et al.; Paliou, C.; Laupert, V.; Chan, W.-L.; Wittler, L.; Mielke, T.; Mundlos, S.: Enhancer adoption by an LTR retrotransposon generates viral-like particles causing developmental limb phenotypes. bioRxiv (2024)

Ravid-Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A.; Stötzel, M. et al.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element. bioRxiv (2022)

Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Phan, M.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M.: Promoter repression and 3D-restructuring resolves divergent developmental gene expression in TADs. bioRxiv (2021)

Despang, A.; Schöpflin, R.; Franke, M.; Ali, S.; Jerkovic, I.; Paliou, C.; Chan, W.-L.; Timmermann, B.; Wittler, L.; Vingron, M. et al.; Mundlos, S.; Ibrahim, D. M.: Functional dissection of TADs reveals non-essential and instructive roles in regulating gene expression. bioRxiv (2019)