Chromatin Biology of Gene Regulatory Domains

Ibrahim Lab

We aim to understand the principles of gene regulation, how they control cell differentiation, and how these are disrupted in disease. We investigate these questions through systematic genome engineering. We synthesize and genetically engineer entire regulatory domains in pluripotent stem cells and study how this alters expression level, pattern, or any other aspect of gene regulation. To do so, we apply cutting-edge functional genomic and epigenetic analyses in vivo, in organoids and in types of clinical relevance.