Transposable elements in early embryogenesis

Fueyo Lab

Incoming group leader - starting in December 2025!

The early stages of mammalian embryogenesis involve the activation of families of endogenous retroviruses (ERVs), also known as LTR-retrotransposons, which constitute about 9% of the human genome. The ERVs repertoire varies significantly across species, hinting at their potential role in shaping species-specific functions.

Our lab investigates fundamental questions regarding the function and regulation of ERVs by leveraging novel human preimplantation models called blastoids, in combination with sophisticated genome-editing technologies.

The intrinsic connection between ERVs and early embryogenesis enables us to uncover quantitative and mechanistic aspects of genome regulation and evolution, offering critical insights into human phenotypic innovation.