Maria Hondele: From Condensation to Control: DEAD-box ATPases as Global Regulators of RNA Granules

Maria Hondele is an assistant professor at the Biozentrum of the University of Basel, Switzerland. After a PhD at EMBL in Heidelberg and LMU Munich, she spent six years as a postdoc with Prof. Karsten Weis at ETH Zurich. Her research focuses on the formation, regulation and function of membraneless organelles, in particular those associated with RNA processing. The lab investigates how condensates influence the cellular ‘flux’ of RNAs, and whether they impact how efficiently an RNA is translated or decayed. They use biochemical reconstitutions, biophysical measurements, screening approaches and imaging to dissect which human DEAD-box ATPases regulate which membraneless organelles, and to characterize their biochemical function.

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