Publications

Demir, S.; Kessler, T.; Hotes, A.; Häberle, B.; Hiyama, E.; Hishiki, T.; Indersie, E.; Branchereau, S.; Vokuhl, C.; Dorel, M. et al.; Lehrach, H.; Lange, B.; Cairo, S.; Kappler, R.: Mechanistic models position ceritinib as a nuclear integrity disrupting therapy in pediatric liver tumors. Journal of Experimental & Clinical Cancer Research 44, 268 (2025)

Hetzel, S.; Hodis , E.; Torlai Triglia, E.; Kovacsovics, A.; Steinmann , K.; Gnirke, A.; Cui, M.; McQuaid, D.; Weigert, R.; Pohl, G. et al.; Muzumdar, M. D.; Leyvraz, S.; Keilholz, U.; Yaspo, M.-L.; Regev, A.; Kretzmer, H.; Smith, Z.; Meissner, A.: Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biology (26) (2025)

Lazaro-Navarro, J.; Alcon, C.; Dorel, M.; Alasfar, L.; Bastian, L.; Baldus, C.; Astrahantseff, K.; Yaspo, M.-L.; Montero, J.; Eckert, C.: Inhibiting H3K27 Demethylases Downregulates CREB-CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia. Cancer Medicine 14 (1), pp. 1 - 7 (2025)

Bortolini Silveira, A.; Houy, A.; Ganier, O.; Özemek, B.; Vanhuele, S.; Vincent-Salomon, A.; Cassoux, N.; Mariani , P.; Pierron, G.; Leyvraz, S. et al.; Rieke, D.; Picca, A.; Bielle, F.; Yaspo, M.-L.; Rodrigues, M.; Stern, M.-H.: Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes. Nature Communications 15 (1), Article 9864 (2024)

Künzel, S. E.; Frentzel, D. P.; Flesch, L. T. M.; Knecht, V. A.; Rübsam, A.; Dreher, F.; Schütte, M.; Dubrac, A.; Lange, B.; Yaspo, M.-L. et al.; Lehrach, H.; Joussen, A. M.; Zeitz, O.: AI-driven discovery of blood xenobiotic biomarkers in neovascular age-related macular degeneration using iterative random forests. Graefe's Archive for Clinical and Experimental Ophthalmology 262 (11), pp. 3567 - 3575 (2024)

Künzel, S. E.; Pompös, I.-M.; Flesch, L. T. M.; Frentzel, D. P.; Knecht, V. A.; Winkler, S.; Skosyrski, S.; Rübsam, A.; Dreher, F.; Kociok, N. et al.; Schütte, M.; Dubrac, A.; Lange, B.; Yaspo, M.-L.; Lehrach, H.; Strauß, O.; Joussen, A. M.; Zeitz, O.: Exploring the Impact of Saccharin on Neovascular Age-Related Macular Degeneration: A Comprehensive Study in Patients and Mice. Investigative Ophthalmology and Visual Science 65 (4), Article 5 (2024)

Sultana, Z.; Dorel, M.; Klinger, B.; Sieber, A.; Dunkel, I.; Blüthgen, N.; Schulz, E. G.: Modeling unveils sex differences of signaling networks in mouse embryonic stem cells. Molecular Systems Biology 19 (11), e11510 (2023)

Ng, M.; Verboon, L.; Issa, H.; Bhayadia, R.; Vermunt, M. W.; Winkler, R.; Schüler, L.; Alejo, O.; Schuschel, K.; Regenyi, E. et al.; Borchert, D.; Heuser, M.; Reinhardt, D.; Yaspo, M.-L.; Heckl, D.; Klusmann, J.-H.: Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15. iScience 26 (10), 107844 (2023)

Gialesaki , S.; Bräuer-Hartmann , D.; Issa, H.; Bhayadia, R.; Alejo-Valle, O.; Verboon, L.; Schmell, A.-L.; Laszig, S.; Regenyi, E.; Schuschel, K. et al.; Labuhn , M.; Ng, M.; Winkler , R.; Ihling, C.; Sinz, A.; Glaß, M.; Hüttelmaier, S.; Matzk, S.; Schmid, L.; Strüwe, F.; Kadel, S.-K.; Reinhardt, D.; Yaspo, M.-L.; Heckl, D.; Klusmann, J.-H.: RUNX1 isoform disequilibrium promotes the development of trisomy 21 associated myeloid leukemia. Blood 141 (10), pp. 1105 - 1118 (2022)

Leyvraz, S.; Konietschke, F.; Peuker, C.; Schütte, M.; Kessler, T.; Ochsenreither, S.; Ditzhaus, M.; Sprünken, E. D.; Dörpholz, G.; Lamping, M. et al.; Rieke, D. T.; Klinghammer, K.; Burock, S.; Ulrich, C.; Poch, G.; Schäfer, R.; Klauschen, F.; Joussen, A.; Yaspo, M.-L.; Keilholz, U.: Biomarker-driven therapies for metastatic uveal melanoma: A prospective precision oncology feasibility study. European Journal of Cancer 169, pp. 146 - 155 (2022)

Berlak, M.; Tucker, E.; Dorel, M.; Winkler, A.; McGearey, A.; Rodriguez-Fos, E.; Martins da Costa, B.; Barker, K.; Fyle, E.; Calton, E. et al.; Eising, S.; Ober, K.; Hughes, D.; Koutroumanidou, E.; Carter, P.; Stankunaite, R.; Proszek, P.; Jain, N.; Rosswog, C.; Dorado-Garcia, H.; Molenaar, J. J.; Hubank, M.; Barone, G.; Anderson, J.; Lang, P.; Deubzer, H. E.; Künkele, A.; Fischer, M.; Eggert, A.; Kloft, C.; Henssen, A. G.; Boettcher, M.; Hertwig, F.; Blüthgen, N.; Chesler, L.; Schulte, J. H.: Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells. Molecular Cancer 21, 126 (2022)

Vuaroqueaux, V.; Musch, A.; Kobelt, D.; Risch, T.; Herrmann, P.; Burock, S.; Peille, A.-L.; Yaspo, M.-L.; Fiebig, H.-H.; Stein, U.: Elevated MACC1 Expression in Colorectal Cancer Is Driven by Chromosomal Instability and Is Associated with Molecular Subtype and Worse Patient Survival. Cancers / Molecular Diversity Preservation International (MDPI) 14 (7), 1749 (2022)

Alejo-Valle, O.; Weigert, K.; Bhayadia, R.; Ng, M.; Issa, H.; Beyer, C.; Emmrich, S.; Schuschel, K.; Ihling, C.; Sinz, A. et al.; Zimmermann, M.; Wickenhauser, C.; Flasinski, M.; Regenyi, E.; Labuhn, M.; Reinhardt, D.; Yaspo, M.-L.; Heckl, D.; Klusmann, J.-H.: The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis. Blood 139 (5), pp. 651 - 665 (2022)

Keil, M.; Conrad, T.; Becker, M.; Keilholz, U.; Yaspo, M.-L.; Lehrach, H.; Schütte, M.; Haybaeck, J.; Hoffmann, J.: Modeling of Personalized Treatments in Colon Cancer Based on Preclinical Genomic and Drug Sensitivity Data. Cancers 13 (23), 6018 (2021)

Xiao, Y.; Rabien, A.; Buschow, R.; Amstislavskiy, V.; Busch, J.; Kilic, E.; Villegas, S. L.; Timmermann, B.; Schütte, M.; Mielke, T. et al.; Yaspo, M.-L.; Jung, K.; Meierhofer, D.: Endocytosis-mediated replenishment of amino acids favors cancer cell proliferation and survival in chromophobe renal cell carcinoma. Cancer research: an official organ of the American Association for Cancer Research 80, pp. 5491 - 5501 (2020)

Bornhauser, B.; Cario, G.; Rinaldi, A.; Risch, T.; Rodriguez Martinez, V.; Schütte, M.; Warnatz, H.-J.; Scheidegger, N.; Mirkowska, P.; Temperli, M. et al.; Möller, C.; Schumich, A.; Dworzak, M.; Attarbaschi, A.; Brüggemann, M.; Ritgen, M.; Mejstrikova, E.; Hofmann, A.; Buldini, B.; Scarparo, P.; Basso, G.; Maglia, O.; Gaipa, G.; Skoblyn, T.-L.; Te Kronnie, G.; Vendramini, E.; Panzer-Grümayer, R.; Barz, M. J.; Marovca, B.; Hauri-Hohl, M.; Niggli, F.; Eckert, C.; Schrappe, M.; Stanulla, M.; Zimmermann, M.; Wollscheid, B.; Yaspo, M.-L.; Bourquin, J.-P.: The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL. Blood Advances 4 (17), pp. 4052 - 4064 (2020)

Burns, M.; Schulz, A. R.; Kunkel, D.; Hönig, M.; Warth, S.; Bengsch, B.; Burns, T.; Reinhardt, J.; Grützkau, A.; Yaspo, M.-L. et al.; Sodenkamp, J.; Hoffmann, U.; Mei, H. E.: Mass Cytometry-A Tool for the Curious: Networking in Berlin. Cytometry Part A 97 (8), pp. 764 - 767 (2020)

Lampignano , R.; Neumann, M. H.D.; Weber, S.; Kloten, V.; Herdean, A.; Voss, T.; Groelz, D.; Babayan, A.; Tibbesma, M.; Schlumpberger, M. et al.; Chemi, F.; Rothwell, D. G.; Wikman, H.; Galizzi, J.-P.; Bergheim, I. R.; Russnes, H.; Mussolin, B.; Bonin, S.; Voigt, C.; Musa, H.; Pinzani, P.; Lianidou, E.; Brady, G.; Speicher, M. R.; Pantel, K.; Betsou, F.; Schuuring, E.; Kubista, M.; Ammerlaan, W.; Sprenger-Haussels, M.; Schlange, T.; Heitzer, E.; Lehrach, H.; Yaspo, M.-L.: Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows. Clinical Chemistry: International Journal of Molecular Diagnostics and Laboratory Medicine 66 (1), pp. 149 - 160 (2020)

Huang, Y.; Mouttet , B.; Warnatz, H.-J.; Risch, T.; Rietmann, F.; Frommelt, F.; Ngo, Q. A.; Dobay, M. P.; Marovca, B.; Jenni, S. et al.; Tsai, Y.-C.; Matzk, S.; Amstislavskiy, V.; Schrappe, M.; Stanulla, M.; Gstaiger, M.; Bornhauser, B.; Yaspo, M.-L.; Bourquin , J.-P.: The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell 36 (6), pp. 630 - 644 (2019)

Christensen, S.; Van der Roest, B.; Besselink, N.; Janssen, R.; Boymans, S.; Martens, J.; Yaspo, M.-L.; Priestley, P.; Kuijk, E.; Cuppen, E. et al.; Van Hoeck, A.: 5-Fluorouracil treatment induces characteristic T>G mutations in human cancer. Nature Communications 10, Article 4571, p. 1 (2019)