Selected Publications

N. Furth, N. Cohen, A. Spitzer, T. Salame, B. Dassa, T. Mehlman, A. Brandis, A. Moussaieff, D. Friedmann-Morvinski, M.G. Castro, J. Fortin, M.L. Suvà, I. Tirosh, A. Erez, G. Ron & E. Shema

Oncogenic IDH1^mut drives robust loss of histone acetylation and increases chromatin heterogeneity

Proc. Natl. Acad. Sci. U.S.A. 122 (2025)

DOI

N. Erez, N. Furth, V. Fedyuk, J. Wadden, R. Aittaleb, T. Adam, K. Schwark, M. Niculcea, M. Miclea, R. Mody, A Franson, H. A. Parmar, M. Ibrahim, B. Lau, A. Eze, N. Nourmohammadi, I. Fried, J Nazarian, G. Ron, S. Venneti, C. Koschmann, E. Shema

Single-molecule systems for the detection and monitoring of plasma-circulating nucleosomes and oncoproteins in diffuse midline glioma

Cell Reports Medicine. 6 (2025)

DOI

Y. Isshiki, X. Chen, M. Teater, I. Karagiannidis, H. Nam, W. Cai, C. Meydan, M. Xia, H. Shen, J. Gutierrez, V. Easwar Kumar, S.E. Carrasco, M.M. Ouseph, S. Yamshon, P. Martin, O. Griess, E. Shema, P. Porazzi, M. Ruella, R.J. Brentjens, G. Inghirami, R. Zappasodi, A. Chadburn, A.M. Melnick, W. Béguelin

EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

Cancer Cell. 43 (2025)

DOI

L. Q. J. Lim, L. Adler, E. Hajaj, L. R. Soria, R. Ben-Tov Perry, N. Darzi, R. Brody, N. Furth, M. Lichtenstein, E. Bab-Dinitz, Z. Porat, T. Melman, A. Brandis, S. Malitsky, M. Itkin, Y. Aylon, S. Ben-Dor, I. Orr, A. Pri-Or, R. Seger, Y. Shaul, E. Ruppin, M. Oren, M. Perez, J. Meier, N. Brunetti-Pierri, E. Shema, I. Ulitsky & A. Erez

ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

Nature metabolism. 6 (2024)

DOI

M. P. Alcolea, D. Alonso-Curbelo, C. Ambrogio, S. Bullman, A. L. Correia, A. Ernst, C. J. Halbrook, G. L. Kelly, A. W. Lund, D. F. Quail, M. Ruscetti, E. Shema, I. M. Stromnes, W. L. Tam

Cancer Hallmarks: Piecing the Puzzle Together

Cancer Discovery. 14 (2024)

DOI

D. Algranati, R. Oren, B. Dassa, L. Fellus-Alyagor, A. Plotnikov, H. Barr, A. Harmelin, N. London, G. Ron, N. Furth, E. Shema

Dual targeting of histone deacetylases and myc as potential treatment strategy for h3- k27m pediatric gliomas

eLife. 13 (2024)

DOI

Shema E.

A single-molecule liquid biopsy for cancer diagnosis

Nature Reviews Cancer. 23 (2023)

DOI

V. Fedyuk, N. Erez, N. Furth, O. Beresh, E. Andreishcheva, A. Shinde, D. Jones, B. B. Zakai, Y. Mavor, T. Peretz, A. Hubert, J. E. Cohen, A. Salah, M. Temper, A. Grinshpun, M. Maoz, A. Zick, G. Ron, E. Shema

Multiplexed, single-molecule, epigenetic analysis of plasma-isolated nucleosomes for cancer diagnostics

Nature Biotechnology. 41 (2023)

DOI

Y. Aylon, N. Furth, G. Mallel, G. Friedlander, N. B. Nataraj, M. Dong, O. Hassin, R. Zoabi, B. Cohen, V. Drendel, T. M. Salame, S. Mukherjee, N. Harpaz, R. Johnson, W. E. Aulitzky, Y. Yarden, E. Shema, M. Oren

Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

Nature Communications. 13 (2022)

DOI

N. Furth, D. Algranati, B. Dassa, O. Beresh, V. Fedyuk, N. Morris, L. H. Kasper, D. Jones, M. Monje, S. J. Baker, E. Shema

H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

Cell Reports. 39 (2022)

DOI

N. Furth & E. Shema

It's all in the combination: decoding the epigenome for cancer research and diagnostics

Current Opinion in Genetics and Development. 73 (2022)

DOI

P. Zheng, M. Wanunu & E. Shema

Real-time single-molecule sequencing of nucleosomal DNA and combinatory histone modifications detection with zero-mode waveguides

Biophysical Journal. 121 (2022)

DOI

D. Sheban, T. Shani, R. Maor, A. Aguilera-Castrejon, N. Mor, B. Oldak, M. D. Shmueli, A.Eisenberg-Lerner, J. Bayerl, J. Hebert, S. Viukov, G. Chen, A. Kacen, V. Krupalnik, V. Chugaeva, S. Tarazi, A. Rodríguez-delaRosa, M. Zerbib, A. Ulman, S. Masarwi, M.Kupervaser, Y. Levin, E. Shema, Y. David, N. Novershtern, J. H. Hanna, Y. Merbl

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

Molecular Cell. 82 (2022)

DOI

K. L. Kim, P. van Galen, V. Hovestadt, G. J. Rahme, E. N. Andreishcheva, A. Shinde, E. Gaskell, D. R. Jones, E. Shema, B. E. Bernstein

Systematic detection of m⁶A-modified transcripts at single-molecule and single-cell resolution

Cell Reports Methods. 1 (2021)

DOI

N. Furth, S. Shilo, N. Cohen, N. Erez, V. Fedyuk, A. M. Schrager, A. Weinberger, A. A. Dror, A. Zigron, M. Shehadeh, E. Sela, S. Srouji, S. Amit, I. Levy, E. Segal, R. Dahan, D. Jones, D. C. Douek, E. Shema

Unified platform for genetic and serological detection of COVID-19 with single-molecule technology

PLoS ONE. 16 (2021)

DOI

I. Vitale, E. Shema, S. Loi & L. Galluzzi

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Nature Medicine. 27 (2021)

DOI