Max Planck Institute for Molecular Genetics

Publications

The following publications were published exclusively under the affiliation of the Max Planck Society. For publications by the principal investigator outside of the Max Planck Society, see the links on the lower left.

Journal Article (20)

Journal Article

Iyer, D. P.; Khoei , H. H.; van der Weijden, V. A.; Kagawa, H.; Pradhan, S. J.; Novatchkova, M.; McCarthy, A.; Rayon, T.; Simon, C. S.; Dunkel, I. et al.; Wamaitha, S. E.; Elder, K.; Snell , P.; Christie, L.; Schulz, E. G.; Niakan, K. K.; Rivron, N.; Bulut-Karslioglu, A.: mTOR activity paces human blastocyst stage developmental progression. Cell 187 (23), pp. 6566 - 6583 (2024)

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publisher-version

Journal Article

Schulz, E. G.; Martitz, A.: Structural remodeling of the inactive X chromosome during early mouse development. Nature Genetics 56 (10), pp. 2004 - 2005 (2024)

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publisher-version

Journal Article

Schulz, E. G.: BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding. Molecular Cell 84 (3), pp. 413 - 414 (2024)

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Journal Article

Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Limberg, E.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A. et al.; Stötzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 25 (11), pp. 1704 - 1715 (2023)

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Journal Article

de Sousa, J. A.; Wong, C.-W.; Dunkel, I.; Owens, T.; Voigt, P.; Hodgson, A.; Baker, D.; Schulz, E. G.; Reik, W.; Smith, A. et al.; Rostovskaya, M.; von Meyenn, F.: Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science Advances 9 (39), eadg1936 (2023)

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Journal Article

Sultana, Z.; Dorel, M.; Klinger, B.; Sieber, A.; Dunkel, I.; Blüthgen, N.; Schulz, E. G.: Modeling unveils sex differences of signaling networks in mouse embryonic stem cells. Molecular Systems Biology 19 (11), e11510 (2023)

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Journal Article

Noviello, G.; Gjaltema, R. A. F.; Schulz, E. G.: CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications 14 (1), 3225 (2023)

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Journal Article

Gjaltema, R. A. F.; Schwämmle, T.; Kautz, P.; Robson, M.; Schöpflin, R.; Ravid Lustig, L.; Brandenburg, L.; Dunkel, I.; Vechiatto, C.; Ntini, E. et al.; Mutzel, V.; Schmiedel, V.; Marsico, A.; Mundlos, S.; Schulz, E. G.: Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Molecular Cell 82 (1), pp. 190 - 208 (2022)

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Journal Article

Pacini, G.; Dunkel, I.; Mages, N.; Mutzel, V.; Timmermann, B.; Marsico, A.; Schulz, E. G.: Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution. Nature Communications 12 (1), 3638 (2021)

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Journal Article

Genolet, O.; Monaco, A. A.; Dunkel, I.; Boettcher, M.; Schulz, E. G.: Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology 22, 110 (2021)

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Journal Article

Mutzel, V.; Schulz, E. G.: Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation. Bioessays 42 (4), e1900163 (2020)

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Journal Article

Barros de Andrade e Sousa, L.; Jonkers, I.; Syx, L.; Dunkel, I.; Chaumeil, J.; Picard, C.; Foret, B.; Chen, C.-J.; Lis, J. T.; Heard, E. et al.; Schulz, E. G.; Marsico, A.: Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Research 29 (7), pp. 1087 - 1099 (2019)

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publisher-version

Journal Article

Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural and Molecular Biology 26 (5), pp. 350 - 360 (2019)

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publisher-version

supplementary-material

Journal Article

Schulz, E. G.: X-chromosome dosage as a modulator of pluripotency, signalling and differentiation? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 372 (1733), pii: 20160366 (2017)

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Journal Article

Zhan, Y.; Mariani, L.; Barozzi, I.; Schulz, E. G.; Blüthgen, N.; Stadler, M.; Tiana, G.; Giorgetti, L.: Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Research 27 (3), pp. 479 - 490 (2017)

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publisher-version

Journal Article

Schulz, E. G.; Meisig, J.; Nakamura, T.; Okamoto, I.; Sieber, A.; Picard, C.; Borensztein, M.; Saitou, M.; Blüthgen, N.; Heard, E.: The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network. Cell Stem Cell 14 (2), pp. 203 - 2016 (2014)

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Journal Article

Schulz, E. G.; Heard, E.: Role and control of X chromosome dosage in mammalian development. Current Opinion in Genetics & Development 23 (2), pp. 109 - 115 (2013)

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Journal Article

Nora, E. P.; Lajoie, B. R.; Schulz, E. G.; Giorgetti, L.; Okamoto, I.; Servant, N.; Piolot, T.; van Berkum, N. L.; Meisig, J.; Sedat, J. et al.; Gribnau, J.; Barillot, E.; Blüthgen, N.; Dekker, J.; Heard, E.: Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 485 (7398), pp. 381 - 385 (2012)

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publisher-version

Journal Article

Schulz, E. G.; Nora , E. P.; Heard, E.: Rnf12—A Jack of All Trades in X Inactivation? PLoS Genetics 7 (1), e1002002 (2011)

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publisher-version

Journal Article

Schulz, E. G.; Mariani, L.; Radbruch, A.; Höfer, T.: Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12. Immunity 30 (5), pp. 673 - 683 (2009)

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Book Chapter (2)

Book Chapter

Genolet, O.; Ravid-Lustig, L.; Schulz, E. G.: Dissecting molecular phenotypes through FACS-based pooled CRISPR screens. In: Embryonic Stem Cell Protocols. Methods in Molecular Biology, 2520., Vol. 2520, pp. 1 - 24 (Ed. Turksen, K.). Humana Press, New York, NY (2022)

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Book Chapter

Gjaltema, R. A. F.; Schulz, E. G.: CRISPR/dCas9 switch systems for temporal transcriptional control. In: Epigenome Editing. Methods in Molecular Biology., Vol. 1767, pp. 167 - 185 (Eds. Jeltsch , A.; Rots, M.). Humana Press, New York (2018)

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Thesis - PhD (6)

Thesis - PhD

Sultana, Z.: Modeling the impact of double X-dosage on pluripotency maintenance in mouse embryonic stem cells. Dissertation (2025)

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Thesis - PhD

Schwämmle, T.: Functional investigation of the regulatory landscape around the Xist locus. Dissertation (2024)

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Thesis - PhD

Noviello, G.: Development of a method to tune endogenous gene expression and its application to study dose-sensitivity in transcriptional regulation and random X-chromosome inactivation. Dissertation (2024)

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Thesis - PhD

Pacini, G.: Transcriptome regulation during the X chromosome inactivation process. Dissertation (2023)

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Thesis - PhD

Mutzel, V.: Experimental and theoretical analysis of X-chromosome inactivation as a paradigm for epigenetic memory and molecular decision-making. Dissertation, 191 pp. (2021)

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Thesis - PhD

Genolet, O.: Identification of X-chromosomal genes that drive global X-dosage effects in mammals. Dissertation (2021)

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Review Article (2)

Review Article

Martitz, A.; Schulz, E. G.: Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation. Current Opinion in Genetics & Development 86, Article 102198 (2024)

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Review Article

Kanata, E.; Duffié, R.; Schulz, E. G.: Establishment and maintenance of random monoallelic expression. Development 151 (10), Article dev201741 (2024)

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Preprint (3)

Preprint

Schwaemmle, T.; Noviello, G.; Kanata, E.; Froehlich, J. J.; Bothe, M.; Altay, A.; Scouarnec, J.; Feng, V.-Y.; Vingron, M.; Schulz, E. G.: Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus. bioRxiv (2024)

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Preprint

Mutzel, V.; Schwämmle, T.; Oeverdieck, S.; Librenjak, L.; Boesen, B.; Bothe, M.; Gjaltema, R. A. F.; Dunkel, I.; Noviello, G.; Schulz, E. G.: Antisense transcription can induce expression memory via stable promoter repression. bioRxiv (2024)

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Preprint

Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X-chromosome inactivation. bioRxiv: the preprint server for biology 2017, pp. 1 - 54 (2017)

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