Selected Publications 2002 – 2021
2021
Dennis Schifferl, Manuela Scholze-Wittler, Lars Wittler, Jesse V. Veenvliet, Frederik Koch and Bernhard G. Herrmann. (2021) A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development. Development 148, dev200059; doi: 10.1242/dev200059
Amaral A, Herrmann BG (2021) RAC1 controls progressive movement and competitiveness of mammalian spermatozoa. PLoS Genetics 17(2): e1009308. doi: 10.1371/journal.pgen.1009308
2020
Veenvliet JV, Bolondi A, Kretzmer H, Haut L, Scholze-Wittler M, Schifferl D, Koch F, Guignard L, Kumar AS, Pustet M, Heimann S, Buschow R, Wittler L, Timmermann B, Meissner A, Herrmann BG. (2020) Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. Science 370 (6522), eaba4937. doi: 10.1126/science.aba4937
Farrall AL, Lienhard M, Grimm C, Kuhl H, Sluka SHM, Caparros M, Forejt J, Timmermann B, Herwig R, Herrmann BG, Morkel M. (2020) PWD/Ph-encoded genetic variants modulate the cellular Wnt/β-Catenin response to suppress ApcMin-triggered intestinal tumor formation. Cancer Research 81 (1), 38 – 49 (2021). doi: 10.1158/0008-5472.CAN-20-1480
Veenvliet JV, Herrmann BG (2020) Modeling mammalian trunk development in a dish. Developmental Biology, Volume 474, 5-15. doi: 10.1016/j.ydbio.2020.12.015
2019
Charron Y, Willert J, Lipkowitz B, Kusecek B, Herrmann BG, Bauer H. (2019) Two isoforms of the RAC-Specific guanine nucleotide exchange factor TIAM2 act oppositely on Transmission Ratio Distortion by the mouse t-haplotype. PLoS Genet 15(2): e1007964. doi: 10.1371/journal.pgen.1007964
2018
Beisaw A, Tsaytler P, Koch F, Schmitz SU, Melissari M-T, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P (2018). BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Reports 19(1):118-134
2017
Koch F, Scholze M, Wittler L, Schifferl D, Sudheer S, Grote P, Timmermann B, Macura K, Herrmann BG (2017). Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Dev Cell 42:514-526 e7
Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Bläß G, Timmermann B, Herrmann BG (2017). Pattering and gastrulation deffects caused by the tw18 lethal are due to loss of Ppp2r1a. Biology Open 6:752-764
2016
Schmitz SU, Grote P, Herrmann BG (2016). Mechanism of noncoding RNA function in development and disease. Cell Mol Life Sci 73:2491-2509
Sudheer S, Liu J, Marks M, Koch F, Anurin A, Scholze M, Senft AD, Wittler L, Macura K, Grote P, Herrmann BG (2016). Different concentrations of FGF Ligand, FGF2 or FGF8 determine distinct states of WNT-induced presomitic mesoderm. Stem Cells 34:1790-1800
Marks M, Pennimpede T, Lange L, Grote P, Herrmann BG,Wittler L (2016). Analysis oft he Fam181 gene family during mouse development reveals distint strain-specific expression patterns, suggesting a role in nervous system development and function. Gene 575:438-451
2015
Grote P & Herrmann BG (2015). Long noncoding RNAs in organogenesis: Making the difference. Trends in Genetics, doi: 10.1016/j.tig.2015.02.002
2014
Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, Bläker H, Herrmann BG & Morkel M (2014). Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-Catenin activity. Oncogene, doi 10.1038/onc. 2014.247
Schwartz B, Marks M, Wittler L, Werber M, Währisch S, Nordheim A, Herrmann BG & Grote P (2014). SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mechanisms of Development, doi: 10.1016/j.mod.2014.07.001
Werber M, Wittler L, Timmermann B, Grote P & Herrmann BG (2014) The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development, 141, 1-6
2013
Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard M, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M. (2013) DNA-methylome analysis of mouse intestinal adenoma identifies a tumor-specific signature that is partly conserved in human colon cancer. PLoS Genetics, 9, e1003250
Grote P & Herrmann BG (2013). The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. RNA Biology, 10, 1–7
Grote P, Wittler L, Hendrix D, Koch F, Währisch S, Macura K, Bläss G, Kellis M, Werber M, Herrmann BG. (2013) The tissue-specific IncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell, Vol. 24, 206-214; doi:10.1016/j.devcel.2012.12.012
2012
Bauer H, Schindler S, Charron Y, Willert J, Kusecek B, Herrmann BG. (2012) The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. PLoS Genetics, Vol. 8 (3), e1002567. Doi:10.1371
Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M. (2012) Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer, No. 3663, DOI: 10.1002/ijc.27500
Geffers L, Herrmann BG, Eichele G. (2012) Web-based Digital Gene Expression Atlases for the Mouse. Mammalian Genome, Vol. 23, 525-538
Herrmann BG, Bauer H. (2012) The mouse t-haplotype: a selfish chromosome – genetics molecular mechanism and evolution. In Evolution of the House Mouse (ed. Macholan, Baird, Munclinger), Cambridge University Press
Pennimpede T, Proske J, König A, Vidigal JA, Morkel M, Bramsen JB, Herrmann BG, Wittler L (2012). In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome. Dev Biol 372, 55–67
2011
Leushacke M, Spörle R, Bernemann C, Brouwer-Lehmitz A, Fritzmann J, Theis M, Buchholz F, Herrmann BG, Morkel M (2011). An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression. PLoS ONE, Vol. 6, e23381
2010
Rocha PP, Bleiss W, Schrewe H (2010). Mosaic Expression of Med12 in Female Mice Leads to Exencephaly, Spina Bifida, and Craniorachischisis. Birth Defects Research (Part A) 88:626-632
Rocha PP, Scholze M, Bleiß W, Schrewe H (2010). Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137, 2723-2731, doi:10.1242/dev.053660. Published by The Company of Biologists Ltd.
Scholz AK, Klebl BM, Morkel M, Lehrach H, Dahl A, Lange BM (2010). A Flexible Multiwell Format for Immunofluorescence Screening Microscopy of Small-Molecule Inhibitors. Assay Drug Dev Technol 8, 571–580
Timmermann B, Kerick M, Roehr C, Fischer A, Isau M, Boerno ST, Wunderlich A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasb M, Bertram L, Trappe K, Werber M, Herrmann BG, Zatloukal K, Lehrach H, Schweiger MR (2010). Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS ONE, Vol. 5 (12) pp. e15661
Vidigal JA, Morkel M, Wittler L, Brouwer-Lehmitz A, Grote P, Macura K, Herrmann BG (2010). An inducible RNA interference system fort he functional dissection of mouse embryogenesis. Nucleic Acids Res 38, e122 (doi:10.1093/nar/gkq199)
2009
Verón N, Bauer H, Weisse A, Lüder G, Werber M, Herrmann BG (2009). Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t-complex-responder. Genes Dev 23, 2705-2710
2008
Deutsch EW, Ball CA, Berman JJ, Bova JS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen J, Daian F, Dauga D, Davidson DR, Gimenez G, Goo YA, Grimmond S, Henrich T, Herrmann BG, Johnson MH, Korb M, Mills JC, Oudes AJ, Parkinson HE, Pascal LE, Pollet N, Quackenbush J, Ramialison M, Ringwald M, Salgado D, Sansone SA, Sherlock G, Stoeckert CJ Jr., Swedlow J, Taylor RC, Walashek L, Warford A, Wilkinson DG, Zhou Y, Zon LI, Liu AY, True LD (2008). Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE). Nature Biotechnology 26, 305-312
2007
Bauer H, Véron N, Willert J, Herrmann BG (2007). The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes Dev 21 (1), 143-147
Wittler L, Shin Eh, Grote P, Kispert A, Beckers A, Gossler A, Werber M, Herrmann BG (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8 (8), 784-789
2006
Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann BG, Pourquié O (2006). Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental Patterning and Morphogenesis in Vertebrate Somitogenesis. Dev Cell 10, 355–366
Grote P & Conradt B (2006). The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Dev Cell 11, 561-573.
2005
Bauer H, Willert J, Koschorz B & Herrmann BG (2005). The t complex−encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nature Genetics 37 (9), 969-973
2004
Abdelkhalek HB, Becker A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Müller I, Hermann BG, Ceolin M, Rivera-Pomar R & Gossler A (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev 18 (14), 1725-1736
Aulehla A & Herrmann BG (2004). Segmentation in vertebrates: clock and gradient finally joined. Genes Dev 18 (17), 2060-2067
Hofmann M, Schuster-Gossler K, Watabe-Rudolph M, Aulehla A, Herrmann BG & Gossler A (2004). WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev 18 (22), 2712-2717
2003
Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG (2003). Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 4 (3), 395-406
2002
Gitton Y, Dahmane N, Baik S, iAltaba AR, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkhala A, Schrinner S, Yildirimman R, Herwig R, Lehrach H & Yaspo ML (2002). A gene expression map of human chromosome 21 orthologues in the mouse. Nature 420 (6917), 586-590 (2002)