Selected Publications 2002 – 2021


Dennis Schifferl, Manuela Scholze-Wittler, Lars Wittler, Jesse V. Veenvliet, Frederik Koch and Bernhard G. Herrmann. (2021) A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail developmentDevelopment 148, dev200059; doi: 10.1242/dev200059 

Amaral A, Herrmann BG (2021) RAC1 controls progressive movement and competitiveness of mammalian spermatozoa. PLoS Genetics 17(2): e1009308. doi: 10.1371/journal.pgen.1009308


Veenvliet JV,  Bolondi A, Kretzmer H, Haut L, Scholze-Wittler M, Schifferl D, Koch F, Guignard L, Kumar AS, Pustet M, Heimann S, Buschow R, Wittler L, Timmermann B, Meissner A, Herrmann BG. (2020) Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. Science 370 (6522), eaba4937. doi: 10.1126/science.aba4937

Farrall AL, Lienhard M, Grimm C, Kuhl H, Sluka SHM, Caparros M, Forejt J, Timmermann B, Herwig R, Herrmann BG, Morkel M. (2020) PWD/Ph-encoded genetic variants modulate the cellular Wnt/β-Catenin response to suppress ApcMin-triggered intestinal tumor formation. Cancer Research 81 (1), 38 – 49 (2021). doi: 10.1158/0008-5472.CAN-20-1480

Veenvliet JV, Herrmann BG (2020) Modeling mammalian trunk development in a dish. Developmental Biology, Volume 474, 5-15. doi: 10.1016/j.ydbio.2020.12.015


Charron Y, Willert J, Lipkowitz B, Kusecek B, Herrmann BG, Bauer H. (2019) Two isoforms of the RAC-Specific guanine nucleotide exchange factor TIAM2 act oppositely on Transmission Ratio Distortion by the mouse t-haplotype. PLoS Genet 15(2): e1007964. doi: 10.1371/journal.pgen.1007964


Beisaw A, Tsaytler P, Koch F, Schmitz SU, Melissari M-T, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P (2018). BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Reports 19(1):118-134


Koch F, Scholze M, Wittler L, Schifferl D, Sudheer S, Grote P, Timmermann B, Macura K, Herrmann BG (2017). Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Dev Cell 42:514-526 e7

Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Bläß G, Timmermann B, Herrmann BG (2017). Pattering and gastrulation deffects caused by the tw18 lethal are due to loss of Ppp2r1a. Biology Open 6:752-764


Schmitz SU, Grote P, Herrmann BG (2016). Mechanism of noncoding RNA function in development and disease. Cell Mol Life Sci 73:2491-2509

Sudheer S, Liu J, Marks M, Koch F, Anurin A, Scholze M, Senft AD, Wittler L, Macura K, Grote P, Herrmann BG (2016). Different concentrations of FGF Ligand, FGF2 or FGF8 determine distinct states of WNT-induced presomitic mesoderm. Stem Cells 34:1790-1800

Marks M, Pennimpede T, Lange L, Grote P, Herrmann BG,Wittler L (2016). Analysis oft he Fam181 gene family during mouse development reveals distint strain-specific expression patterns, suggesting a role in nervous system development and function. Gene 575:438-451


Grote P & Herrmann BG (2015). Long noncoding RNAs in organogenesis: Making the difference. Trends in Genetics, doi: 10.1016/j.tig.2015.02.002


Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, Bläker H, Herrmann BG & Morkel M (2014). Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-Catenin activity. Oncogene, doi 10.1038/onc. 2014.247

Schwartz B, Marks M, Wittler L, Werber M, Währisch S, Nordheim A, Herrmann BG & Grote P (2014). SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mechanisms of Development, doi: 10.1016/j.mod.2014.07.001

Werber M, Wittler L, Timmermann B, Grote P & Herrmann BG (2014) The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development, 141, 1-6


Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard M, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M. (2013) DNA-methylome analysis of mouse intestinal adenoma identifies a tumor-specific signature that is partly conserved in human colon cancer. PLoS Genetics, 9, e1003250

Grote P & Herrmann BG (2013). The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. RNA Biology, 10, 1–7

Grote P, Wittler L, Hendrix D, Koch F, Währisch S, Macura K, Bläss G, Kellis M, Werber M, Herrmann BG. (2013) The tissue-specific IncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell, Vol. 24, 206-214; doi:10.1016/j.devcel.2012.12.012


Bauer H, Schindler S, Charron Y, Willert J, Kusecek B, Herrmann BG. (2012) The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. PLoS Genetics, Vol. 8 (3), e1002567. Doi:10.1371

Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M. (2012) Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer, No. 3663, DOI: 10.1002/ijc.27500

Geffers L, Herrmann BG,  Eichele G. (2012)  Web-based Digital Gene Expression Atlases for the Mouse. Mammalian Genome, Vol. 23, 525-538

Herrmann BG, Bauer H. (2012) The mouse t-haplotype: a selfish chromosome – genetics molecular mechanism and evolution. In Evolution of the House Mouse (ed. Macholan, Baird, Munclinger), Cambridge University Press

Pennimpede T, Proske J, König A, Vidigal JA, Morkel M, Bramsen JB, Herrmann BG, Wittler  L (2012). In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome. Dev Biol 372, 55–67


Leushacke M, Spörle R, Bernemann C, Brouwer-Lehmitz A, Fritzmann J, Theis M, Buchholz F, Herrmann BG, Morkel M (2011). An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression. PLoS ONE, Vol. 6, e23381


Rocha PP, Bleiss W, Schrewe H (2010). Mosaic Expression of Med12 in Female Mice Leads to Exencephaly, Spina Bifida, and Craniorachischisis. Birth Defects Research (Part A) 88:626-632

Rocha PP, Scholze M, Bleiß W, Schrewe H (2010). Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137, 2723-2731, doi:10.1242/dev.053660. Published by The Company of Biologists Ltd.

Scholz AK, Klebl BM, Morkel M, Lehrach H, Dahl A, Lange BM (2010). A Flexible Multiwell Format for Immunofluorescence Screening Microscopy of Small-Molecule Inhibitors. Assay Drug Dev Technol 8, 571–580

Timmermann B, Kerick M, Roehr C, Fischer A, Isau M, Boerno ST, Wunderlich A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasb M, Bertram L, Trappe K, Werber M, Herrmann BG, Zatloukal K, Lehrach H, Schweiger MR (2010). Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS ONE, Vol. 5 (12) pp. e15661

Vidigal JA, Morkel M, Wittler L, Brouwer-Lehmitz A, Grote P, Macura K, Herrmann BG (2010). An inducible RNA interference system fort he functional dissection of mouse embryogenesis. Nucleic Acids Res 38, e122 (doi:10.1093/nar/gkq199)


Verón N, Bauer H, Weisse A, Lüder G, Werber M, Herrmann BG (2009). Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t-complex-responder. Genes Dev 23, 2705-2710


Deutsch EW, Ball CA, Berman JJ, Bova JS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen J, Daian F, Dauga D, Davidson DR, Gimenez G, Goo YA, Grimmond S, Henrich T,  Herrmann BG, Johnson MH, Korb M, Mills JC, Oudes AJ, Parkinson HE, Pascal LE, Pollet N, Quackenbush J, Ramialison M, Ringwald M, Salgado D, Sansone SA, Sherlock G, Stoeckert CJ Jr., Swedlow J, Taylor RC, Walashek L, Warford A, Wilkinson DG, Zhou Y, Zon LI, Liu AY, True LD (2008).  Minimum Information Specification For In Situ Hybridization and Immunohistochemistry Experiments (MISFISHIE). Nature Biotechnology 26, 305-312


Bauer H, Véron N, Willert J, Herrmann BG (2007). The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes Dev 21 (1), 143-147

Wittler L, Shin Eh, Grote P, Kispert A, Beckers A, Gossler A, Werber M, Herrmann BG (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8 (8), 784-789


Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann BG, Pourquié O (2006). Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental Patterning and Morphogenesis in Vertebrate Somitogenesis. Dev Cell 10, 355–366

Grote P & Conradt B (2006). The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Dev Cell 11, 561-573.


Bauer H, Willert J, Koschorz B & Herrmann BG (2005). The t complex−encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nature Genetics 37 (9), 969-973


Abdelkhalek HB, Becker A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Müller I, Hermann BG, Ceolin M, Rivera-Pomar R & Gossler A (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev 18 (14), 1725-1736

Aulehla A & Herrmann BG (2004). Segmentation in vertebrates: clock and gradient finally joined. Genes Dev 18 (17), 2060-2067

Hofmann M, Schuster-Gossler K, Watabe-Rudolph M, Aulehla A, Herrmann BG & Gossler A (2004). WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev 18 (22), 2712-2717


Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG (2003). Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 4 (3), 395-406


Gitton Y, Dahmane N, Baik S, iAltaba AR, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkhala A, Schrinner S, Yildirimman R, Herwig R, Lehrach H & Yaspo ML (2002). A gene expression map of human chromosome 21 orthologues in the mouse. Nature 420 (6917), 586-590 (2002)

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