Publications of Sara Hetzel

Batki, J.; Hetzel, S.; Schifferl, D.; Bolondi, A.; Walther, M.; Wittler, L.; Grosswendt, S.; Herrmann, B. G.; Meissner, A.: Extraembryonic gut endoderm cells undergo programmed cell death during development. Nature Cell Biology 26 (6), pp. 868 - 877 (2024)

Hauswedell , H.; Hetzel, S.; Gottlieb , S. G.; Kretzmer, H.; Meissner, A.; Reinert, K.: Lambda3: homology search for protein, nucleotide, and bisulfite-converted sequences. Bioinformatics 40 (3), Article btae097 (2024)

Klever, M.-K.; Sträng , E.; Hetzel, S.; Jungnitsch, J.; Dolnik, A.; Schöpflin, R.; Schrezenmeier, J.-F.; Schick, F.; Blau, O.; Westermann, J. et al.; Rücker , F. G. ..; Xia, Z.; Döhner, K.; Schrezenmeier, H.; Spielmann, M.; Meissner, A.; Melo, U. S.; Mundlos, S.; Bullinger, L.: AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology. Blood Advances 7 (21), pp. 6520 - 6531 (2023)

Weigert, R.; Hetzel, S.; Bailly, N.; Haggerty, C.; Ilik, I. A.; Kwong Yung, P. Y.; Navarro, C.; Bolondi, A.; Sampath Kumar, A.; Anania, C. et al.; Brändl, B.; Meierhofer, D.; Lupiáñez, D. G.; Müller, F.-J.; Aktas, T.; Elsässer, S. J.; Kretzmer, H.; Smith, Z. D.; Meissner, A.: Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nature Cell Biology 25 (4), pp. 579 - 591 (2023)

Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Glaser, J.; Phan, M. H. Q.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S. A.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M. I.: Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Cell 185 (20), pp. 3689 - 3704 (2022)

Asimi, V.; Sampath Kumar, A.; Niskanen, H.; Riemenschneider, C.; Hetzel, S.; Naderi, J.; Fasching, N.; Popitsch, N.; Du, M.; Kretzmer, H. et al.; Smith, Z. D.; Weigert, R.; Walther, M.; Mamde, S.; Meierhofer, D.; Wittler, L.; Buschow, R.; Timmermann, B.; Cisse, I. I.; Ameres, S. L.; Meissner, A.; Hnisz, D.: Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics 54, pp. 1238 - 1247 (2022)

Hetzel, S.; Mattei, A. L.; Kretzmer, H.; Qu, C.; Chen, X.; Fan, Y.; Wu, G.; Roberts, K. G.; Luger, S.; Litzow, M. et al.; Rowe, J.; Paietta, E.; Stock, W.; Mardis, E. R.; Wilson, R. K.; Downing, J. R.; Mullighan, C. G.; Meissner, A.: Acute lymphoblastic leukemia displays a distinct highly methylated genome. Nature Cancer 3 (6), pp. 768 - 782 (2022)

Hetzel, S.; Gießelmann, P.; Reinert, K.; Meissner, A.; Kretzmer, H.: RLM: Fast and simplified extraction of Read-Level Methylation metrics from bisulfite sequencing data. Bioinformatics 37 (21), pp. 3934 - 3935 (2021)

Rossmann, M. P.; Hoi, K.; Chan, V.; Abraham, B. J.; Yang, S.; Mullahoo, J.; Papanastasiou, M.; Wang, Y.; Elia, I.; Perlin, J. R. et al.; Hagedorn, E. J.; Hetzel, S.; Weigert, R.; Vyas, S.; Nag, P. P.; Sullivan, L. B.; Warren, C. R.; Dorjsuren, B.; Custo Greig, E.; Adatto, I.; Cowan, C. A.; Schreiber, S. L.; Young, R. A.; Meissner, A.; Haigis, M. C.; Hekimi, S.; Carr, S. A.; Zon, L. I.: Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science 372 (6543), pp. 716 - 721 (2021)

Grosswendt, S.; Kretzmer, H.; Smith, Z. D.; Sampath Kumar, A.; Hetzel, S.; Wittler, L.; Klages, S.; Timmermann, B.; Mukherji, S.; Meissner, A.: Epigenetic regulator function through mouse gastrulation. Nature 584, pp. 102 - 108 (2020)

Giesselmann, P.; Hetzel, S.; Müller, F.-J.; Meissner, A.; Kretzmer, H.: Nanopype: A modular and scalable nanopore data processing pipeline. Bioinformatics 35 (22), pp. 4770 - 4772 (2019)

Klever, M.-K.; Sträng, E.; Jungnitsch, J.; Melo, U. S.; Hetzel, S.; Dolnik, A.; Schöpflin, R.; Schrezenmeier, J. F.; Blau, O.; Westermann, J. et al.; Döhner, K.; Schrezenmeier, H.; Spielmann, M.; Meissner, A.; Mundlos, S.; Bullinger, L.: Integration of Hi-C and Nanopore Sequencing for Structural Variant Analysis in AML with a Complex Karyotype: (Chromothripsis)². 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH) (Virtual meeting), December 05, 2020 - December 08, 2020. Blood 136, S28, (2020)

Rossmann, M.; Hoi, K.; Chan, V.; Abraham, B.; Yang, S.; Mullahoo, J.; Papanastasiou, M.; Elia, I.; Vyas, S.; Nag, P. et al.; Sullivan, L.; Perlin, J.; Hagedorn, E.; Hetzel, S.; Weigert, R.; Warren, C.; Dorjsuren, B.; Custo Greig, E.; Adatto, I.; Cowan, C.; Schreiber, S.; Young, R.; Meissner, A.; Haigis, M.; Carr, S.; Zon, L.: Transcriptional regulation of mitochondrial metabolism by TIF1γ drives erythroid progenitor differentiation. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology (Virtual Meeting), New York City, USA, August 19, 2020 - August 21, 2020. Experimental Hematology 88, S35, (2020)

Hetzel, S.: Investigation of DNA methylation heterogeneity in cancer. Dissertation (2023)

Smith, Z. D.; Hetzel, S.; Meissner, A.: DNA methylation in mammalian development and disease. Nature Reviews Genetics 26 (1), pp. 7 - 30 (2025)

Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Phan, M.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M.: Promoter repression and 3D-restructuring resolves divergent developmental gene expression in TADs. bioRxiv (2021)