Publications of S. R. Connell

Ratje, A. H.; Loerke, J.; Mikolajka, A.; Brunner, M.; Hildebrand, P. W.; Starosta, A. L.; Donhofer, A.; Connell, S. R.; Fucini, P.; Mielke, T. et al.; Whitford, P. C.; Onuchic, J. N.; Yu, Y.; Sanbonmatsu, K. Y.; Hartmann, R. K.; Penczek, P. A.; Wilson, D. N.; Spahn, C. M.: Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature 468 (7324), pp. 713 - 716 (2010)

Jan-Christian Schuette, J.-C.; Murphy, F. V.; Kelley, A. C.; Weir, J. R.; Giesebrecht, J.; Connell, S. R.; Loerke, J.; Mielke, T.; Zhang, W.; Penczek, P. A. et al.; Ramakrishnan, V.; Spahn, C. M. T.: GTPase activation of elongation factor EF-Tu by the ribosome during decoding. The EMBO Journal 28 (6), pp. 755 - 765 (2009)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), pp. 910 - 915 (2008)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), pp. 910 - 915 (2008)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), pp. 910 - 915 (2008)

Connell, S. R.; Takemoto, C.; Wilson, D. N.; Wang, H.; Murayama, K.; Terada, T.; Shirouzu, M.; Rost, M.; Schüler, M.; Giesebrecht, J. et al.; Dabrowski, M.; Mielke, T.; Fucini, P.; Yokoyama, S.; Spahn, C. M. T.: Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors. Molecular Cell 25 (5), pp. 751 - 764 (2007)

Schüler, M.; Connell, S. R.; Lescoute, A.; Giesebrecht, J.; Dabrowski, M.; Schroeer, B.; Mielke, T.; Penczek, P. A.; Westhof, E.; Spahn, C. M. T.: Structure of the ribosome-bound cricket paralysis virus IRES RNA. Nature Structural & Molecular Biology 13 (12), pp. 1092 - 1096 (2006)

Owens, R. M.; Pritchard, G.; Skipp, P.; Hodey, M.; Connell, S. R.; Nierhaus, K. H.; O'Connor, C. D.: A dedicated translation factor controls the synthesis of the global regulator Fis. EMBO Journal 23 (16), pp. 3375 - 3385 (2004)

Christodoulou, J.; Larsson, G.; Fucini, P.; Connell, S. R.; Pertinhez, T. A.; Hanson, C. L.; Redfield, C.; Nierhaus, K. H.; Robinson, C. V.; Schleucher, J. et al.; Dobson, C. M.: Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes. Proceedings of the National Academy of Sciences 101 (30), pp. 10949 - 10954 (2004)

Gilbert, R. J. C.; Fucini, P.; Connell, S.; Fuller, S. D.; Nierhaus, K. H.; Robinson, C. V.; Dobson, C. M.; Stuart, D. I.: Three-dimensional structures of translating ribosomes by Cryo-EM. Molecular Cell 14 (1), pp. 57 - 66 (2004)

Connell, S. R.; Tracz, D. M.; Nierhaus, K. H.; Taylor, D. E.: Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrobial Agents and Chemotherapy 47 (12), pp. 3675 - 3681 (2003)

Dinos, G. P.; Connell, S. R.; Nierhaus, K. H.; Kalpaxis, D. L.: Erythromycin, roxithromycin, and clarithromycin: Use of slow-binding kinetics to compare their in vitro interaction with a bacterial ribosomal complex active in peptide bond formation. Molecular Pharmacology 63 (3), pp. 617 - 623 (2003)

Connell, S. R.; Trieber, C. A.; Dinos, G. P.; Einfeldt, E.; Taylor, D. E.; Nierhaus, K. H.: Mechanism of Tet(O)-mediated tetracycline resistance. EMBO Journal 22 (4), pp. 945 - 953 (2003)

Connell, S. R.; Trieber, C. A.; Stelzl, U.; Einfeldt, E.; Taylor, D. E.; Nierhaus, K. H.: The tetracycline resistance protein Tet() perturbs the conformation of the ribosomal decoding centre. Molecular Microbiology 45 (6), pp. 1463 - 1472 (2002)

Wilson, D. N.; Blaha, G.; Connell, S. R.; Ivanov, P. V.; Jenke, H.; Stelzl, U.; Teraoka, Y.; Nierhaus, K. H.: Protein Synthesis at Atomic Resolution: Mechanistics of Translation in the Light of Highly Resolved Structures for the Ribosome. Current Protein and Peptide Science 3 (1), pp. 1 - 53 (2002)