DNA methylation is a prevalent epigenetic mark in mammalian genomes, with essential roles for development. Over the past years, our team has made significant contribution in understanding the role of this mark for spermatogenesis and male fertility. I will present our latest work that demonstrates that sperm production relies on a division of labor between two DNA methylation enzymes, with specialized and non-redundant functions in developing germ cells: transposon control or stem cell homeostasis. [more]

[more]

As part of the GP write consortium, Romain Koszul is involved in rewriting the yeast (and other genomes). His lab engineers synthetic chromosomes and develops software to analyse 3D chromatin structure or to use Hi-C for genome assembly. With wet lab and computation, it’s fun for everyone! [more]

Does every gene affect the phenotypic variation in every complex trait? [more]

"Mediator condensates localize signaling factors to key cell identity genes" [more]

The endovirome, its polydactyl controllers and the species-specificity of human transcriptional networks [more]

"Pervasive transcription: Origins and impact on the expression and stability of the yeast genome" [more]

"SMCHD1: To Have, or not Have, a Nose" [more]

“Self-organisation of the pluripotent linage during mouse peri-implantation development” [more]

"Transcription during DNA damage" [more]

"Signal integration in alternative splicing networks" [more]

"How to get published-Perspectives from a Nature Biotechnology editor" [more]

"DNA methylation and the causes of Rett syndrome" [more]

"Regulation of RNA-protein interactions" [more]

Modeling differentiation and stimulation response in single-cell genomics [more]

"Viewing nuclear architecture through the eyes of nocturnal mammals" [more]

"Early differentiation decisions in a 3D developmental model - What can we learn from embryoid bodies?" [more]

Long-term single-cell quantification: New tools for old questions [more]

Function of cell cycle in stem cell differentiation [more]

A battlefield: Signaling during fertilization and embryo activation in plants [more]

"Integration of regulatory RNAs in the cellular networks" [more]

"Phenotypic noise in metabolic systems" [more]

“In vivo selection to enhance cell and gene therapy for the liver” [more]

"Detecting and manipulating chromosome structure in vivo without crosslinking and ligation” [more]

“Accessible chromatin mapping of human and mouse at single base-pair resolution” [more]

"Transcription of the genome: from molecular movies to regulatory systems" [more]

"PHF3 binds RNA polymerase II via the SPOC domain and regulates transcription of neuronal genes" [more]

"Editing fate changing marks" [more]

[more]

"Single-cell and population genetic approaches to understand developmental evolution" [more]

"balancing RNA levels" [more]

"Novel players regulating chromatin function" [more]

"Restricting the extent of transcription across the mammalian genome to prevent the formation of pathological RNA" [more]

"Predicting Functional Mechanisms from public CLIP-seq data" [more]

"Mining the genome: Novel tissue-specific genes and lincRNAs in human inflammation" [more]

"Probing gene control via chemical protein degradation" [more]

"Mechanisms involved in reading and writing of methyl marks" [more]