Multi-Level Gene Control Group

Hnisz lab

We seek to understand how transcriptional programs are established during development, how their corruption leads to human pathologies, and how this knowledge can be used for therapeutic manipulation of human disease genes. We operate on the interphase of biology, chemistry and physics in a highly collaborative way to solve fundamental problems in gene regulation, currently using embryonic stem cells, cancer models, state-of-the art genetic and biochemical perturbation technologies, genome structure mapping and computational methods.