Publications

Hetzel, S.; Hodis , E.; Torlai Triglia, E.; Kovacsovics, A.; Steinmann , K.; Gnirke, A.; Cui, M.; McQuaid, D.; Weigert, R.; Pohl, G. et al.; Muzumdar, M. D.; Leyvraz, S.; Keilholz, U.; Yaspo, M.-L.; Regev, A.; Kretzmer, H.; Smith, Z.; Meissner, A.: Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biology (26) (2025)

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Yagi, M.; Bonilla, G.; Hoetker, M. S.; Tsopoulidis, N.; Horng, J. E.; Haggerty, C.; Meissner, A.; Sadreyev, R. I.; Hock, H.; Hochedlinger, K.: Bivalent chromatin instructs lineage specification during hematopoiesis. Cell (2025)

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Wang, G.; Korody, M. L.; Brändl, B.; Hernandez-Toro, C. J.; Rohrandt, C.; Hong, K.; Pang, A. W. C.; Lee, J.; Migliorelli, G.; Stanke, M. et al.; Ford, S. M.; Pollmann, I.; Houck, M. L.; Lewin, H. A.; Lear, T. L.; Ryder, O. A.; Meissner, A.; Loring, J. F.; Müller, F.-J.: Genomic map of the functionally extinct northern white rhinoceros (Ceratotherium simum cottoni). Proceedings of the National Academy of Sciences of the United States of America 122 (20) (2025)

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Haggerty, C.: Uncovering regulatory principles of mammalian methylomes. Dissertation (2025)

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Guckelberger, P.: Investigating the role of chromatin regulators in genome function. Dissertation, xv, 249 pp. (2025)

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Smith, Z. D.; Hetzel, S.; Meissner, A.: DNA methylation in mammalian development and disease. Nature Reviews Genetics 26 (1), pp. 7 - 30 (2025)

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2024

Hasenbein, T. P.; Hoelzl, S.; Smith, Z. D.; Gerhardinger, C.; Gonner, M. O. C.; Aguilar-Pimentel, A.; Amarie, O. V.; Becker, L.; Calzada-Wack, J.; Dragano, N. R. V. et al.; da Silva-Buttkus, P.; Garrett, L.; Hölter, S. M.; Kraiger, M.; Östereicher, M. A.; Rathkolb, B.; Sanz-Moreno, A.; Spielmann, N.; Wurst, W.; Gailus-Durner, V.; Fuchs, H.; Hrabě de Angelis, M.; Meissner, A.; Engelhardt, S.; Rinn, J. L.; Andergassen, D.: X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes. Nature Communications 15 (1), Article 10631 (2024)

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Stötzel, M.; Cheng, C.-Y.; Ilik, I. A.; Sampath Kumar, A.; Akbari-Omgba, P.; van der Weijden, V. A.; Zhang, Y.; Vingron, M.; Meissner, A.; Aktas, T. et al.; Kretzmer, H.; Bulut-Karslioglu, A.: TET activity safeguards pluripotency throughout embryonic dormancy. Nature Structural & Molecular Biology 31 (10), pp. 1625 - 1639 (2024)

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Guckelberger, P.; Doughty, B. R.; Munson, G.; Rao, S. S. P.; Tan, Y.; Cai, X. S.; Fulco, C. P.; Nasser, J.; Mualim, K. S.; Bergman, D. T. et al.; Ray, J.; Jagoda, E.; Munger, C. J.; Gschwind, A. R.; Sheth, M. U.; Tan, A. S.; Pulido, S. G.; Mitra, N.; Weisz, D.; Shamim, M. S.; Durand, N. C.; Mahajan, R.; Khan, R.; Steinmetz, L. M.; Kanemaki, M. T.; Lander, E. S.; Meissner, A.; Lieberman Aiden, E.; Engreitz, J. M.: Cohesin-mediated 3D contacts tune enhancer-promoter regulation. bioRxiv (2024)

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pre-print

Batki, J.; Hetzel, S.; Schifferl, D.; Bolondi, A.; Walther, M.; Wittler, L.; Grosswendt, S.; Herrmann, B. G.; Meissner, A.: Extraembryonic gut endoderm cells undergo programmed cell death during development. Nature Cell Biology 26 (6), pp. 868 - 877 (2024)

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Bolondi, A.; Law, B. K.; Kretzmer, H.; Gassaloglu, S. I.; Buschow, R.; Riemenschneider, C.; Yang, D.; Walther, M.; Veenvliet, J. V.; Meissner, A. et al.; Smith, Z. D.; Chan, M. M.: Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids. Developmental Cell 59 (12), pp. 1489 - 1505 (2024)

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Sato, N. S.; Rosa , V. S.; Makhlouf, A.; Kretzmer, H.; Sampath Kumar, A.; Grosswendt, S.; Mattei, A. L.; Courbot, O.; Wolf, S.; Boulanger, J. et al.; Langevin, F.; Wiacek, M.; Karpinski, D.; Elosegui-Artola, A.; Meissner, A.; Zernicka-Goetz , M.; Shahbazi, M. N.: Basal delamination during mouse gastrulation primes pluripotent cells for differentiation. Developmental Cell 59 (10), pp. 1252 - 1268 (2024)

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Hetzel, S.: Investigation of DNA methylation heterogeneity in cancer. Dissertation, xix, 198 pp pp. (2024)

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Hauswedell , H.; Hetzel, S.; Gottlieb , S. G.; Kretzmer, H.; Meissner, A.; Reinert, K.: Lambda3: homology search for protein, nucleotide, and bisulfite-converted sequences. Bioinformatics 40 (3), Article btae097 (2024)

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Haut, L.: Investigation of DNA methylation turnover in pluripotency and early differentiation. Dissertation, 146 Seiten pp. (2024)

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Li, Z.; Peluffo, G.; Stevens, L.; Qiu, X.; Seehawer, M.; Huang, X.-Y.; Egri, S.; Papanastasiou, M.; Kingston, N.; D'Santos, C. et al.; Papachristou, E.; Nishida, J.; Evans, K.; Seo, J.-H.; Clement, K.; Temko, D.; Ekram, M.; Rees, M.; Ronan, M.; Roth, J.; Simeonov, A.; Kales, S.; Rai, G.; Lal-Nag, M.; Maloney, D.; Jadhav, A.; Michor, F.; Meissner, A.; Balko, J.; Carroll, J.; Freedman, M.; Long, H.; Jaffe, J.; Polyak, K.: KDM4C histone demethylase connects redox balance to chromatin remodeling via histone H3 tail clipping. AACR Special Conference on Cancer Research - Advances in Breast Cancer Research, San Diego, CA, October 19, 2023 - October 22, 2023. Cancer Research 84 (Suppl. 1), Article B008, (2024)

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2023

Klever, M.-K.; Sträng , E.; Hetzel, S.; Jungnitsch, J.; Dolnik, A.; Schöpflin, R.; Schrezenmeier, J.-F.; Schick, F.; Blau, O.; Westermann, J. et al.; Rücker , F. G. ..; Xia, Z.; Döhner, K.; Schrezenmeier, H.; Spielmann, M.; Meissner, A.; Melo, U. S.; Mundlos, S.; Bullinger, L.: AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology. Blood Advances 7 (21), pp. 6520 - 6531 (2023)

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Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Limberg, E.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A. et al.; Stötzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 25 (11), pp. 1704 - 1715 (2023)

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Hoetker, M. S.; Yagi, M.; Di Stefano, B.; Langerman, J.; Cristea, S.; Ping Wong, L.; Huebner, A. J.; Charlton, J.; Deng, W.; Haggerty, C. et al.; Sadreyev, R. I.; Meissner, A.; Michor, F.; Plath, K.; Hochedlinger, K.: H3K36 methylation maintains cell identity by regulating opposing lineage programmes. Nature Cell Biology 25, pp. 1121 - 1134 (2023)

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Sampath Kumar, A.; Tian, L.; Bolondi, A.; Aragonés Hernández, A.; Stickels, R.; Kretzmer, H.; Murray, E.; Wittler, L.; Walther, M.; Barakat, G. et al.; Haut, L.; Elkabetz, Y.; Macosko, E. Z.; Guignard, L.; Chen, F.; Meissner, A.: Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nature Genetics 55 (7), pp. 1176 - 1185 (2023)

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Guo, H.; Vuille, J. A.; Wittner, B. S.; Lachtara, E. M.; Hou, Y.; Lin, M.; Zhao, T.; Raman, A. T.; Russell, H. C.; Reeves, B. A. et al.; Pleskow, H. M.; Wu, C.-L.; Gnirke, A.; Meissner, A.; Efstathiou, J. A.; Lee, R. J.; Toner, M.; Aryee, M. J.; Lawrence, M. S.; Miyamoto, D. T.; Maheswaran, S.; Haber, D. A.: DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs. Cell 186 (13), pp. 2765 - 2782 (2023)

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Sampath Kumar, A.: Spatiotemporal architecture of mouse embryogenesis at single-cell resolution. Dissertation, xvi, 124 pp. (2023)

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Riemenschneider, C.: Reacquisition and maintenance of pluripotency. Dissertation, xvi, 123 pp. (2023)

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Weigert, R.; Hetzel, S.; Bailly, N.; Haggerty, C.; Ilik, I. A.; Kwong Yung, P. Y.; Navarro, C.; Bolondi, A.; Sampath Kumar, A.; Anania, C. et al.; Brändl, B.; Meierhofer, D.; Lupiáñez, D. G.; Müller, F.-J.; Aktas, T.; Elsässer, S. J.; Kretzmer, H.; Smith, Z. D.; Meissner, A.: Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nature Cell Biology 25 (4), pp. 579 - 591 (2023)

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Landshammer, A.; Bolondi, A.; Kretzmer, H.; Much, C.; Buschow, R.; Rose, A.; Wu, H.-J.; Mackowiak, S. D.; Braendl, B.; Gießelmann, P. et al.; Tornisiello, R.; Mohan Parsi, K.; Huey, J.; Mielke, T.; Meierhofer, D.; Maehr, R.; Hnisz, D.; Michor, F.; Rinn, J. L.; Meissner, A.: T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation. eLife 12, Article e83077 (2023)

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Stevens , L. E.; Peluffo, G.; Qiu, X.; Temko , D.; Fassl , A.; Li , Z.; Trinh , A.; Seehawer, M.; Jovanovic, B.; Aleckovic , M. et al.; Wilde , C. M.; Geck, R. C.; Shu, S.; Kingston, N. L.; Harper, N. W.; Almendro, V.; Pyke, A. L.; Egri , S. B.; Papanastasiou, M.; Clement , K.; Zhou , N.; Walker, S.; Salas, J.; Park, S. Y.; Frank, D. A.; Meissner, A.; Jaffe , J. D.; Sicinski , P.; Toker, A.; Michor , F.; Long , H. W.; Overmoyer , B. A.; Polyak, K.: JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states. Cancer research: an official organ of the American Association for Cancer Research 83 (2), pp. 264 - 284 (2023)

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Bailly, N.: Dissecting structural and biochemical features of DNA methyltransferase 1. Dissertation, xix, 195 pp. (2023)

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2022

Knisbacher, B. A.; Lin, Z.; Hahn, C. K.; Nadeu, F.; Duran-Ferrer, M.; Stevenson, K. E.; Tausch, E.; Delgado, J.; Barbera-Mourelle, A.; Taylor-Weiner, A. et al.; Bousquets-Muñoz, P.; Diaz-Navarro, A.; Dunford, A.; Anand, S.; Kretzmer, H.; Gutierrez-Abril, J.; López-Tamargo, S.; Fernandes, S. M.; Sun, C.; Sivina, M.; Rassenti, L. Z.; Schneider, C.; Li, S.; Parida, L.; Meissner, A.; Aguet , F.; Burger, J. A.; Wiestner, A.; Kipps, T. J.; Brown, J. R.; Hallek, M.; Stewart, C.; Neuberg, D. S.; Martín-Subero , J. I.; Puente, X. S.; Stilgenbauer, S.; Wu, C. J.; Campo, E.; Getz, G.: Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nature Genetics 54, pp. 1664 - 1674 (2022)

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Kubelt , C.; Brändl , B.; van Bömmel , A.; Rohrandt, C.; Wang, G.; Evers , M.; Kolkenbrock , S.; Wong, D.; Danso, D.; Maicher, A. et al.; Friedrichsen , S.; Proescholdt , M.; Riemenschneider , M.; Jetzek, U.; Meissner, A.; Yip , S.; Kretzmer, H.; Synowitz, M.; Müller, F.-J.: INTRAEPIGLIOM - RAPID SEQUENCING-BASED DIAGNOSIS OF BRAIN TUMORS. 27th Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), Tampa, FL, November 16, 2022 - November 20, 2022. Neuro-Oncology: official journal of the World Federation of Neuro-Oncology 24, Suppl. 7 Ed., pp. 160 - 161 (2022)

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Weigert, R.: Dissecting the epigenetic regulation of the placental methylome. Dissertation, v, 142 Seiten pp. (2022)

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Ringel, A.; Szabo, Q.; Chiariello, A. M.; Chudzik, K.; Schöpflin, R.; Rothe, P.; Mattei, A. L.; Zehnder, T.; Harnett, D.; Laupert, V. et al.; Bianco, S.; Hetzel, S.; Glaser, J.; Phan, M. H. Q.; Schindler, M.; Ibrahim, D. M.; Paliou, C.; Esposito, A.; Prada-Medina, C. A.; Haas, S. A.; Giere, P.; Vingron, M.; Wittler, L.; Meissner, A.; Nicodemi, M.; Cavalli, G.; Bantignies, F.; Mundlos, S.; Robson, M. I.: Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes. Cell 185 (20), pp. 3689 - 3704 (2022)

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Landshammer, A.: Study of the human SOX17 locus and its genetic determinants in definitive endoderm. Dissertation, XII, 167 Seiten pp. (2022)

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Asimi, V.; Sampath Kumar, A.; Niskanen, H.; Riemenschneider, C.; Hetzel, S.; Naderi, J.; Fasching, N.; Popitsch, N.; Du, M.; Kretzmer, H. et al.; Smith, Z. D.; Weigert, R.; Walther, M.; Mamde, S.; Meierhofer, D.; Wittler, L.; Buschow, R.; Timmermann, B.; Cisse, I. I.; Ameres, S. L.; Meissner, A.; Hnisz, D.: Hijacking of transcriptional condensates by endogenous retroviruses. Nature Genetics 54 (8), pp. 1238 - 1247 (2022)

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Yuan, W.; Ma, S.; Brown, J. R.; Kim, K.; Murek, V.; Trastulla, L.; Meissner, A.; Lodato, S.; Shetty, A. S.; Levin, J. Z. et al.; Buenrostro, J. D.; Ziller, M. J.; Arlotta, P.: Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex. Nature Neuroscience 25 (8), pp. 1049 - 1058 (2022)

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supplementary-material

Bolondi, A.; Kretzmer, H.; Meissner, A.: Single-cell technologies: a new lens into epigenetic regulation in development. Current Opinion in Genetics & Development 76, 101947 (2022)

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Bolondi, A.: Generation and molecular characterization of mouse embryonic stem cells derived Trunk-Like Structures. Dissertation, IX, 168 pp. (2022)

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Mattei, A. L.; Bailly, N.; Meissner, A.: DNA methylation: a historical perspective. Trends in Genetics 38 (7), pp. 676 - 707 (2022)

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Hetzel, S.; Mattei, A. L.; Kretzmer, H.; Qu, C.; Chen, X.; Fan, Y.; Wu, G.; Roberts, K. G.; Luger, S.; Litzow, M. et al.; Rowe, J.; Paietta, E.; Stock, W.; Mardis, E. R.; Wilson, R. K.; Downing, J. R.; Mullighan, C. G.; Meissner, A.: Acute lymphoblastic leukemia displays a distinct highly methylated genome. Nature Cancer 3 (6), pp. 768 - 782 (2022)

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Pour, M.; Sampath Kumar, A.; Farag, N.; Bolondi, A.; Kretzmer, H.; Walther, M.; Wittler, L.; Meissner, A.; Nachman, I.: Emergence and patterning dynamics of mouse-definitive endoderm. iScience 25 (1), 103556 (2022)

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Huang, Y.-H.; Chen, C.-W.; Sundaramurthy, V.; Słabicki, M.; Hao, D.; Watson, C. J.; Tovy, A.; Reyes, J. M.; Dakhova, O.; Crovetti, B. R. et al.; Galonska, C.; Lee, M.; Brunetti, L.; Zhou, Y.; Tatton-Brown, K.; Huang, Y.; Cheng, X.; Meissner, A.; Valk, P. J. M.; Van Maldergem, L.; Sanders, M. A.; Blundell, J. R.; Li, W.; Ebert, B. L.; Goodell, M. A.: Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor. Cancer Discovery 12 (1), pp. 220 - 235 (2022)

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2021

Biran, A.; Yin, S.; Kretzmer, H.; ten Hacken, E.; Parvin, S.; Lucas, F.; Uduman, M.; Gutierrez, C.; Dangle, N. ....; Meissner, A. et al.; Wu, C. J.: Activation of Notch and Myc Signaling via B-cell-Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia. Cancer Research 81 (24), pp. 6117 - 6130 (2021)

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Gießelmann, P.: Genome Analysis Methods using Long Read Nanopore Sequencing. Dissertation, xiv, 105 pp. (2021)

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Mattei, A. L.: Dissecting the embryonic and extraembryonic requirements for DNA methylation in mice. Dissertation, xviii, 214 pp. (2021)

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Blanco, M. A.; Sykes, D. B.; Gu, L.; Wu, M.; Petroni, R.; Karnik, R.; Wawer, M.; Rico, J.; Li, H.; Jacobus, W. D. et al.; Jambhekar, A.; Cheloufi, S.; Meissner, A.; Hochedlinger, K.; Scadden, D. T.; Shi, Y.: Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Reports 37 (6), 109967 (2021)

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Andergassen, D.; Smith, Z. D.; Kretzmer, H.; Rinn, J. L.; Meissner, A.: Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages. Developmental Cell 56 (21), pp. 2995 - 3005 (2021)

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ZIP

Hetzel, S.; Gießelmann, P.; Reinert, K.; Meissner, A.; Kretzmer, H.: RLM: Fast and simplified extraction of Read-Level Methylation metrics from bisulfite sequencing data. Bioinformatics 37 (21), pp. 3934 - 3935 (2021)

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Gu, H.; Raman, A. T.; Wang, X.; Gaiti, F.; Chaligne, R.; Mohammad, A. W.; Arczewska, A. A.; Smith, Z. D.; Landau, D. A.; Aryee, M. J. et al.; Meissner, A.; Gnirke, A.: Smart-RRBS for single-cell methylome and transcriptome analysis. Nature Protocols 16, pp. 4004 - 4030 (2021)

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Yagi , M.; Ji, F.; Charlton, J.; Cristea, S.; Messemer, K.; Horwitz, N.; Di Stefano, B.; Tsopoulidis, N.; Hoetker, M. S.; Huebner, A. J. et al.; Bar-Nur, O.; Almada, A. E.; Yamamoto, M.; Patelunas, A.; Goldhamer, D. J.; Wagers, A. J.; Michor, F.; Meissner, A.; Sadreyev, R. I.; Hochedlinger, K.: Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes and Development 35 (17-18), pp. 1209 - 1228 (2021)

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Wu, H.-J.; Landshammer, A.; Stamenova, E. K.; Bolondi, A.; Kretzmer, H.; Meissner, A.; Michor, F.: Topological isolation of developmental regulators in mammalian genomes. Nature Communications 12 (1), Article 4897 (2021)

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Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Sampath Kumar, A.; Mattei, A. L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B. et al.; Giehr, P.; Buschow, R.; Galonska, C.; von Meyenn, F.; Pappalardi, M. B.; McCabe, M. T.; Wittler, L.; Giesecke-Thiel, C.; Mielke, T.; Meierhofer, D.; Timmermann, B.; Müller, F.-J.; Walter, J.; Meissner, A.: Dnmt1 has de novo activity targeted to transposable elements. Nature Structural and Molecular Biology 28 (7), pp. 594 - 603 (2021)

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Bolondi, A.; Haut, L.; Gassaloglu, S. I.; Burton, P.; Kretzmer, H.; Buschow, R.; Meissner, A.; Herrmann, B. G.; Veenvliet, J. V.: Generation of Mouse Pluripotent Stem Cell-derived Trunk-like Structures: An in vitro Model of Post-implantation Embryogenesis. Bio-protocol 11 (11), e4042 (2021)

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Rossmann, M. P.; Hoi, K.; Chan, V.; Abraham, B. J.; Yang, S.; Mullahoo, J.; Papanastasiou, M.; Wang, Y.; Elia, I.; Perlin, J. R. et al.; Hagedorn, E. J.; Hetzel, S.; Weigert, R.; Vyas, S.; Nag, P. P.; Sullivan, L. B.; Warren, C. R.; Dorjsuren, B.; Custo Greig, E.; Adatto, I.; Cowan, C. A.; Schreiber, S. L.; Young, R. A.; Meissner, A.; Haigis, M. C.; Hekimi, S.; Carr, S. A.; Zon, L. I.: Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science 372 (6543), pp. 716 - 721 (2021)

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Pan, H.; Renaud, L.; Chaligne, R.; Bloehdorn, J.; Tausch, E.; Mertens, D.; Fink, A. M.; Fischer, K.; Zhang, C.; Betel, D. et al.; Gnirke, A.; Imielinski, M.; Moreaux, J.; Hallek, M.; Meissner, A.; Stilgenbauer, S.; Wu, C. J.; Elemento, O.; Landau, D. A.: Discovery of candidate DNA methylation cancer driver genes. Cancer Discovery 11 (9), pp. 2266 - 2281 (2021)

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Sieńska, A. A.: The consequences of DNA methylation maintenance deficiency in human Embryonic Stem Cells. Dissertation, 159 Seiten, 15 ungezählte Seiten pp. (2021)

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Kretzmer, H.; Biran, A.; Purroy, N.; Lemvigh, C. K.; Clement, K.; Gruber, M.; Gu, H.; Rassenti, L.; Mohammad, A. W.; Lesnick, C. et al.; Slager, S. L.; Braggio, E.; Shanafelt, T. D.; Kay, N. E.; Fernandes, S. M.; Brown, J. R.; Wang, L.; Li, S.; Livak, K. J.; Neuberg, D. S.; Klages, S.; Timmermann, B.; Kipps, T. J.; Campo, E.; Gnirke, A.; Wu, C. J.; Meissner, A.: Pre-neoplastic alterations define CLL DNA methylome and persist through disease progression and therapy. Blood Cancer Discovery 2 (1), pp. 54 - 69 (2021)

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2020

Veenvliet, J. V.; Bolondi, A.; Kretzmer, H.; Haut, L.; Scholze-Wittler, M.; Schifferl, D.; Koch, F.; Guignard, L.; Sampath Kumar, A.; Pustet, M. et al.; Heimann, S.; Buschow, R.; Wittler, L.; Timmermann, B.; Meissner, A.; Herrmann, B. G.: Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites. Science 370 (6522), eaba4937 (2020)

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Meissner, A.; Hirsch, C.; Fritz, G.; Adjaye, J.; Schupp, N.: iPSC differentiating into renal proximal tubular cells are vulnerable to oxidative stress. 27th Annual Conference of the Society-for-Redox-Biology-and-Medicine (SfRBM) (Virtual meeting), November 18, 2020 - November 20, 2020. Free Radical Biology and Medicine 159, pp. S109 - S110 (2020)

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Klever, M.-K.; Sträng, E.; Jungnitsch, J.; Melo, U. S.; Hetzel, S.; Dolnik, A.; Schöpflin, R.; Schrezenmeier, J. F.; Blau, O.; Westermann, J. et al.; Döhner, K.; Schrezenmeier, H.; Spielmann, M.; Meissner, A.; Mundlos, S.; Bullinger, L.: Integration of Hi-C and Nanopore Sequencing for Structural Variant Analysis in AML with a Complex Karyotype: (Chromothripsis)². 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH) (Virtual meeting), December 05, 2020 - December 08, 2020. Blood 136, Article 28, (2020)

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Knisbacher, B. A.; Lin, Z.; Hahn, C. K.; Nadeu, F.; Duran-Ferrer, M.; Stevenson, K. E.; Tausch, E.; Barbera-Mourelle, A.; Dunford, A.; Anand, S. et al.; Delgado, J.; Hess, J. M.; Taylor-Weiner, A.; Kretzmer, H.; Bousquets Muñoz, P.; Shaughnessy, C. J.; Fernandes, S. M.; Sivina, M.; Rassenti, L. Z.; Meissner, A.; Wiestner, A. ....; Getz, G.: The CLL-1100 Project: Towards Complete Genomic Characterization and Improved Prognostics for CLL. 62nd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH) (Virtual meeting), December 05, 2020 - December 08, 2020. Blood 136, Article 3, (2020)

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Pan, H.; Renaud, L.; Chaligne, R.; Bloehdorn, J.; Tausch, E.; Mertens, D.; Fink, A.-M.; Fischer, K.; Zhang, C.; Betel , D. et al.; Gnirke, A.; Imielinski, M.; Moreaux , J.; Hallek, M.; Meissner, A.; Stilgenbauer, S.; Wu, C. J.; Elemento, O.; Landau, D. A.: Robust Discovery of Candidate DNA Methylation Cancer Drivers. 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH) (Virtual meeting), December 05, 2020 - December 08, 2020. Blood 136, pp. 33 - 34 (2020)

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McGuire, A. L.; Gabriel, S.; Tishkoff, S. A.; Wonkam, A.; Chakravarti, A.; Furlong, E. E. M.; Treutlein, B.; Meissner, A.; Chang, H. Y.; López-Bigas, N. et al.; Segal, E.; Kim, J.-S.: The road ahead in genetics and genomics. Nature Reviews Genetics 21 (10), pp. 581 - 596 (2020)

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Grosswendt, S.; Kretzmer, H.; Smith, Z. D.; Sampath Kumar, A.; Hetzel, S.; Wittler, L.; Klages, S.; Timmermann, B.; Mukherji, S.; Meissner, A.: Epigenetic regulator function through mouse gastrulation. Nature 584 (7819), pp. 102 - 108 (2020)

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Charlton, J.; Jung, E. J.; Mattei, A. L.; Bailly, N.; Liao, J.; Martin, E. J.; Gießelmann, P.; Brändl, B.; Stamenova, E. K.; Müller, F.-J. et al.; Kiskinis, E.; Gnirke, A.; Smith, Z. D.; Meissner, A.: TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers. Nature Genetics 52 (8), pp. 819 - 827 (2020)

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Rossmann, M.; Hoi, K.; Chan, V.; Abraham, B.; Yang, S.; Mullahoo, J.; Papanastasiou, M.; Elia, I.; Vyas, S.; Nag, P. et al.; Sullivan, L.; Perlin, J.; Hagedorn, E.; Hetzel, S.; Weigert, R.; Warren, C.; Dorjsuren, B.; Custo Greig, E.; Adatto, I.; Cowan, C.; Schreiber, S.; Young, R.; Meissner, A.; Haigis, M.; Carr, S.; Zon, L.: Transcriptional regulation of mitochondrial metabolism by TIF1γ drives erythroid progenitor differentiation. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology (Virtual Meeting), New York City, USA, August 19, 2020 - August 21, 2020. Experimental Hematology 88, S35, (2020)

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The ENCODE Project Consortium; Snyder, M. P.; Gingeras, T. R.; Moore, J. E.; Weng, Z.; Gerstein, M. B.; Ren, B.; Hardison, R. C.; Stamatoyannopoulos, J. A.; Graveley, B. R. et al.; Feingold, E. A.; Pazin, M. J.; Pagan, M.; Gilchrist, D. A.; Hitz, B. C.; Cherry, J. M.; Bernstein, B. E.; Mendenhall, E. M.; Zerbino, D. R.; Frankish, A.; Flicek, P.; Myers , R. M.; Meissner, A.: Perspectives on ENCODE. Nature 583, pp. 693 - 698 (2020)

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Yagi, M.; Kabata, M.; Tanaka, A.; Ukai, T.; Ohta, S.; Nakabayashi, K.; Shimizu, M.; Hata, K.; Meissner, A.; Yamamoto, T. et al.; Yamada, Y.: Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. Nature Communications 11, 3199 (2020)

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Basu, S.; Mackowiak, S.; Niskanen, H.; Knezevic, D.; Asimi, V.; Grosswendt, S.; Geertsema, H.; Ali, S.; Jerković, I.; Ewers, H. et al.; Mundlos, S.; Meissner, A.; Ibrahim, D. M.; Hnisz, D.: Unblending of Transcriptional Condensates in Human Repeat Expansion Disease. Cell 181 (5), pp. 1062 - 1079 (2020)

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Huyghe, A.; Furlan, G.; Ozmadenci, D.; Galonska, C.; Charlton, J.; Gaume, X.; Combémorel, N.; Riemenschneider, C.; Allègre, N.; Zhang, J. et al.; Wajda, P.; Rama, N.; Vieugué, P.; Durand, I.; Brevet , M.; Gadot, N.; Imhof, T.; Merrill , B. J.; Koch, M.; Mehlen, P.; Chazaud, C.; Meissner, A.; Lavial , F.: Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling. Nature Cell Biology 22 (4), pp. 389 - 400 (2020)

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Gokhman, D.; Nissim-Rafinia, M.; Agranat-Tamir, L.; Housman, G.; García-Pérez, R.; Lizano, E.; Cheronet, O.; Mallick, S.; Nieves-Colón, M. A.; Li, H. et al.; Alpaslan-Roodenberg, S.; Novak, M.; Gu, H.; Osinski, J. M.; Ferrando-Bernal, M.; Gelabert, P.; Lipende, I.; Mjungu, D.; Kondova, I.; Bontrop, R.; Kullmer, O.; Weber, G.; Shahar, T.; Dvir-Ginzberg, M.; Faerman, M.; Quillen, E. E.; Meissner, A.; Lahav, Y.; Kandel, L.; Liebergall, M.; Prada, M. E.; Vidal, J. M.; Gronostajski, R. M.; Stone, A. C.; Yakir, B.; Lalueza-Fox, C.; Pinhasi, R.; Reich, D.; Marques-Bonet, T.; Meshorer, E.; Carmel, L.: Differential DNA methylation of vocal and facial anatomy genes in modern humans. Nature Communications 11, 1189 (2020)

MPG.PuRe

Alvarez-Dominguez, J. R.; Donaghey, J.; Rasouli, N.; Kenty, J. H. R.; Helman, A.; Charlton, J.; Straubhaar, J. R.; Meissner, A.; Melton, D. A.: Circadian Entrainment Triggers Maturation of Human In Vitro Islets. Cell Stem Cell 26 (1), pp. 108 - 122 (2020)

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2019

Gießelmann, P.; Brändl, B.; Raimondeau, E.; Bowen, R.; Rohrandt, C.; Tandon, R.; Kretzmer, H.; Assum, G.; Galonska, C.; Siebert, R. et al.; Ammerpohl, O.; Heron, A.; Schneider, S. A.; Ladewig, J.; Koch, P.; Schuldt, B. M.; Graham, J. E.; Meissner, A.; Müller, F.-J.: Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing. Nature Biotechnology 37 (12), pp. 1478 - 1481 (2019)

MPG.PuRe

Kottakis, F.; Nicolay, B. N.; Roumane, A.; Karnik, R.; Gu, H.; Nagle, J. M.; Boukhali, M.; Hayward, M. C.; Li, Y. Y.; Chen, T. et al.; Liesa, M.; Hammerman, P. S.; Wong, K. K.; Hayes, D. N.; Shirihai, O. S.; Dyson, N. J.; Haas, W.; Meissner, A.; Bardeesy, N.: Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 575 (7783), E5 (2019)

MPG.PuRe

Andergassen, D.; Smith, Z. D.; Lewandowski, J. P.; Gerhardinger, C.; Meissner, A.; Rinn, J. L.: In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation. eLife 8, e47214 (2019)

MPG.PuRe

Biran, A.; Kretzmer, H.; Yin, S.; Billington, L.; Regis, F. F.; Mohammad, A. W.; Gnirke, A.; Neuberg, D. S.; Carrasco, R. D.; Meissner, A. et al.; Wu, C. J.: Deciphering the Role of Locally Disordered DNA Methylation on CLL Development In Vivo. Blood 134 (Suppl. 1), p. 1737 - 1737 (2019)

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Di Stefano, B.; Luo, E.-C.; Haggerty, C.; Aigner, S.; Charlton, J.; Brumbaugh, J.; Ji, F.; Rabano Jiménez, I.; Clowers, K. J.; Huebner, A. J. et al.; Clement, K.; Lipchina, I.; de Kort, M. A. C.; Anselmo, A.; Pulice, J.; Gerli, M. F. M.; Gu, H.; Gygi, S. P.; Sadreyev, R. I.; Meissner, A.; Yeo, G. W.; Hochedlinger, K.: The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis. Cell Stem Cell 25 (5), pp. 622 - 638 (2019)

MPG.PuRe

Brumbaugh , J.; Kim, I. S.; Ji, F.; Huebner, A. J.; Di Stefano , B.; Schwarz, B. A.; Charlton, J.; Coffey, A.; Choi, J.; Walsh, R. M. et al.; Schindler, J. W.; Anselmo, A.; Meissner, A.; Sadreyev, R. I.; Bernstein, B. E.; Hock, H.; Hochedlinger , K.: Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo. Nature Cell Biology 21 (11), pp. 1449 - 1461 (2019)

MPG.PuRe

Thakurela, S.; Sindhu, C.; Yurkovsky, E.; Riemenschneider, C.; Smith, Z. D.; Nachman, I.; Meissner, A.: Differential regulation of OCT4 targets facilitates reacquisition of pluripotency. Nature Communications 10, 4444 (2019)

MPG.PuRe

Tsankov, A. M.; Wadsworth, M. H.; Akopian, V.; Charlton, J.; Allon, S. J.; Arczewska, A. A.; Mead, B. E.; Drake, R. S.; Smith, Z. D.; Mikkelsen, T. S. et al.; Shalek, A. K.; Meissner, A.: Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression. Development 146 (19), dev174722 (2019)

MPG.PuRe

Jönsson, M. E.; Brattas, P. L.; Gustafsson, C.; Petri, R.; Yudovich, D.; Pircs, K.; Verschuere, S.; Madsen, S.; Hansson, J.; Larsson, J. et al.; Mansson, R.; Meissner, A.; Jakobsson, J.: Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors. Nature Communications 10, 3182 (2019)

MPG.PuRe

Giesselmann, P.; Hetzel, S.; Müller, F.-J.; Meissner, A.; Kretzmer, H.: Nanopype: A modular and scalable nanopore data processing pipeline. Bioinformatics 35 (22), pp. 4770 - 4772 (2019)

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supplementary-material

Modic, M.; Grosch, M.; Rot, G.; Schirge, S.; Lepko, T.; Yamazaki, T.; Lee, F. C. Y.; Rusha, E.; Shaposhnikov, D.; Palo, M. et al.; Merl-Pham, J.; Cacchiarelli, D.; Rogelj, B.; Hauck, S. M.; von Mering, C.; Meissner, A.; Lickert, H.; Hirose, T.; Drukker, M.: Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Molecular Cell 74 (5), pp. 951 - 965 (2019)

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Chan, M. M.; Smith, Z. D.; Grosswendt, S.; Kretzmer, H.; Norman, T. M.; Adamson, B.; Jost, M.; Quinn, J. J.; Yang, D.; Jones, M. G. et al.; Khodaverdian, A.; Nir, Y.; Meissner, A.; Weissman, J. S.: Molecular recording of mammalian Embryogenesis. Nature 570 (7759), pp. 77 - 82 (2019)

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Gaiti, F.; Chaligne, R.; Gu, H.; Brand, R. M.; Kothen-Hill, S.; Schulman, R. C.; Grigorev, K.; Risso, D.; Kim, K.-T.; Pastore, A. et al.; Huang, K. Y.; Alonso, A.; Sheridan, C.; Omans, N. D.; Biederstedt, E.; Clement, K.; Wang, L.; Felsenfeld, J. A.; Bhavsar, E. B.; Aryee, M. J.; Allan, J. N.; Furman, R.; Gnirke, A.; Wu, C. J.; Meissner, A.; Landau, D. A.: Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia. Nature 569 (7757), pp. 576 - 580 (2019)

MPG.PuRe

Pastore, A.; Gaiti, F.; Lu, S. X.; Brand, R. M.; Kulm, S.; Chaligne, R.; Gu, H.; Huang, K. Y.; Stamenova, E. K.; Béguelin, W. et al.; Jiang, Y.; Chulman, R. C.; Kim, K.-T.; Alonso, A.; Allan, J. N.; Furman, R. R.; Gnirke, A.; Wu, C. J.; Melnick, A. M.; Meissner, A.; Bernstein, B. E.; Abdel-Wahab, O.; Landau, D. A.: Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL. Nature Communications 10 (1), 1874 (2019)

MPG.PuRe

Hinohara, K.; Wu, H.-J.; Vigneau, S.; McDonald, T. O.; Igarashi, K. J.; Yamamoto, K. N.; Madsen, T.; Fassl, A.; Egri, S. B.; Papanastasiou, M. et al.; Ding, L.; Peluffo, G.; Cohen, O.; Kales, S. C.; Lal-Nag, M.; Rai, G.; Maloney, D. J.; Jadhav, A.; Simeonov, A.; Wagle, N.; Brown, M.; Meissner, A.; Sicinski, P.; Jaffe, J. D.; Jeselsohn, R.; Gimelbrant, A. A.; Michor, F.; Polyak, K.: KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. Cancer Cell 35 (2), pp. 330 - 332 (2019)

MPG.PuRe

Klein, H.-U.; McCabe, C.; Gjoneska, E.; Sullivan, S. E.; Kaskow, B. J.; Tang, A.; Smith, R. V.; Xu, J.; Pfenning, A. R.; Bernstein, B. E. et al.; Meissner, A.; Schneider, J. A.; Mostafavi, S.; Tsai, L.-H.; Young-Pearse, T. L.; Bennett, D. A.; De Jager, P. L.: Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nature Neuroscience 22 (1), pp. 37 - 46 (2019)

MPG.PuRe

2018

Zhang, Y.; Charlton, J.; Karnik, R.; Beerman, I.; Smith, Z. D.; Gu, H.; Boyle, P.; Mi , X.; Clement, K.; Pop, R. et al.; Gnirke, A.; Rossi, D. J.; Meissner, A.: Targets and genomic constraints of ectopic Dnmt3b expression. eLife 7, e40757 (2018)

MPG.PuRe

Ichida, J. K.; Staats, K. A.; Davis-Dusenbery, B. N.; Clement, K.; Galloway, K. E.; Babos, K. N.; Shi, Y.; Son, E. Y.; Kiskinis, E.; Atwater, N. et al.; Gu, H.; Gnirke, A.; Meissner, A.; Eggan, K.: Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development 145 (22), pii: dev168617 (2018)

MPG.PuRe

Bernstein, E.; Meissner, A.; Ramalho-Santos, M.: Paying PIs from grants blocks talent and diversity. Nature 563 (7731), p. 325 (2018)

MPG.PuRe

correspondence

Rajavelu, A.; Lungu, C.; Emperle, M.; Dukatz, M.; Bröhm, A.; Broche, J.; Hanelt, I.; Parsa, E.; Schiffers, S.; Karnik, R. et al.; Meissner, A.; Carell, T.; Rathert, P.; Jurkowska, R. Z.; Jeltsch, A.: Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Research (London) 46 (17), pp. 9044 - 9056 (2018)

MPG.PuRe

Cacchiarelli, D.; Qiu, X.; Srivatsan, S.; Manfredi, A.; Ziller, M.; Overbey, E.; Grimaldi, A.; Grimsby, J.; Pokharel, P.; Livak, K. J. et al.; Li, S.; Meissner, A.; Mikkelsen, T. S.; Rinn, J. L.; Trapnell, C.: Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome. Cell Systems 7 (3), pp. 258 - 268 (2018)

MPG.PuRe

Di Stefano, B.; Ueda, M.; Sabri, S.; Brumbaugh, J.; Huebner, A. J.; Sahakyan, A.; Clement, K.; Clowers, K. J.; Erickson, A. R.; Shioda, K. et al.; Gygi, S. P.; Gu, H.; Shioda, T.; Meissner, A.; Takashima, Y.; Plath, K.; Hochedlinger, K.: Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nature methods 15 (9), pp. 732 - 740 (2018)

MPG.PuRe

Schwarz, B. A.; Cetinbas, M.; Clement, K.; Walsh, R. M.; Cheloufi, S.; Gu, H.; Langkabel, J.; Kamiya, A.; Schorle, H.; Meissner, A. et al.; Sadreyev, R. I.; Hochedlinger, K.: Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell 23 (2), pp. 289 - 305 (2018)

MPG.PuRe

Nehme, R.; Zuccaro, E.; Ghosh, S. D.; Li, C.; Sherwood, J. L.; Pietilainen, O.; Barrett, L. E.; Limone, F.; Worringer, K. A.; Kommineni, S. et al.; Zang, Y.; Cacchiarelli, D.; Meissner, A.; Adolfsson, R.; Haggarty, S.; Madison, J.; Muller, M.; Arlotta, P.; Fu, Z.; Feng, G.; Eggan, K.: Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Reports 23 (8), pp. 2509 - 2523 (2018)

MPG.PuRe

Pasque, V.; Karnik, R.; Chronis, C.; Petrella, P.; Langerman, J.; Bonora, G.; Song, J.; Vanheer, L.; Dimashkie, A. S.; Meissner, A. et al.; Plath, K.: X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. Stem Cell Reports 10 (5), pp. 1537 - 1550 (2018)

MPG.PuRe

Shukla, S. A.; Bachireddy, P.; Schilling, B.; Galonska, C.; Zhan, Q.; Bango, C.; Langer, R.; Lee, P. C.; Gusenleitner, D.; Keskin, D. B. et al.; Babadi, M.; Mohammad, A.; Gnirke, A.; Clement, K.; Cartun, Z. J.; Van Allen, E. M.; Miao, D.; Huang, Y.; Snyder, A.; Merghoub, T.; Wolchok, J. D.; Garraway, L. A.; Meissner, A.; Weber, J. S.; Hacohen, N.; Neuberg, D.; Potts, P. R.; Murphy, G. F.; Lian, C. G.; Schadendorf, D.; Hodi, F. S.; Wu, C. J.: Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell 173 (3), pp. 624 - 633 (2018)

MPG.PuRe

Cesana, M.; Guo, M. H.; Cacchiarelli, D.; Wahlster, L.; Barragan, J.; Doulatov, S.; Vo, L. T.; Salvatori, B.; Trapnell, C.; Clement, K. et al.; Cahan, P.; Tsanov, K. M.; Sousa, P. M.; Tazon-Vega, B.; Bolondi, A.; Giorgi, F. M.; Califano, A.; Rinn, J. L.; Meissner, A.; Hirschhorn, J. N.; Daley, G. Q.: A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development. Cell Stem Cell 22 (4), pp. 575 - 588 (2018)

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