Max Planck Institute for Molecular Genetics

Publications

The following publications were published exclusively under the affiliation of the Max Planck Society. For publications by the principal investigator outside of the Max Planck Society, see the links on the lower left.

Publication by Aktas Lab

Preprints

If preprints are available, they will be listed here.

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Published

2025

Review Article

Ilik, I. A.; Yang, X.; Zhang, Z. Z.; Aktas, T.: Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease. Nature Reviews Molecular Cell Biology (2025)

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Journal Article

Zhang, Y.; Stöppelkamp, I.; Fernandez-Pernas, P.; Allram, M.; Charman, M.; Magalhães, A. P.; Piedavent-Salomon, M.; Sommer, G.; Sung, Y.-C.; Meyer, K. et al.; Grams, N.; Halko, E.; Dongre, S.; Meierhofer, D.; Malszycki, M.; Ilik, I. A.; Aktas, T.; Kraushar, M. L.; Vastenhouw, N.; Weitzman, M. D.; Grebien, F.; Niskanen, H.; Hnisz, D.: Probing condensate microenvironments with a micropeptide killswitch. Nature (2025)

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publisher-version

Journal Article

Martina, L.; Malszycki, M.; Aktas, T.: Distinct states of Nuclear Speckles emerge as new predictors of cancer prognosis. Cancer Research 85 (8), pp. 1352 - 1353 (2025)

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2024

Journal Article

Stötzel, M.; Cheng, C.-Y.; Ilik, I. A.; Sampath Kumar, A.; Akbari-Omgba, P.; van der Weijden, V. A.; Zhang, Y.; Vingron, M.; Meissner, A.; Aktas, T. et al.; Kretzmer, H.; Bulut-Karslioglu, A.: TET activity safeguards pluripotency throughout embryonic dormancy. Nature Structural & Molecular Biology 31 (10), pp. 1625 - 1639 (2024)

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Journal Article

Kellner, M.; Hörmann, J.; Fackler, S.; Yuanyu, H.; Tielin, Z.; Lin, L.; Ilik, I.; Aktas, T.; Feederle, R.; Hauck, S. M. et al.; Gires, O.; Gärtner, K.; Lietao, L.; Zeidler, R.: The Nuclear Speckles Protein SRRM2 Is Exposed on the Surface of Cancer Cells. Cells 13 (18), Article 1563 (2024)

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Journal Article

Lisowski, P.; Lickfett, S.; Rybak-Wolf, A.; Menacho, C.; Le, S.; Pentimalli, T. M.; Notopoulou, S.; Dykstra, W.; Oehler, D.; López-Calcerrada, S. et al.; Mlody, B.; Otto, M.; Wu, H.; Richter, Y.; Roth, P.; Anand, R.; Kulka, L. A. M.; Meierhofer, D.; Glazar, P.; Legnini, I.; Telugu, N. S.; Hahn, T.; Neuendorf, N.; Miller, D. C.; Böddrich, A.; Polzin, A.; Mayatepek, E.; Diecke, S.; Olzscha, H.; Kirstein, J.; Ugalde, C.; Petrakis, S.; Cambridge, S.; Rajewsky, N.; Kühn, R.; Wanker, E. E.; Priller, J.; Metzger, J. J.; Prigione, A.: Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Nature Communications 15 (1), Article 7027 (2024)

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Journal Article

Ilik, I. A.; Glažar, P.; Tse, K.; Brändl, B.; Meierhofer, D.; Müller, F.-J.; Smith, Z. D.; Aktas, T.: Autonomous transposons tune their sequences to ensure somatic suppression. Nature 626 (8001), pp. 1116 - 1124 (2024)

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2023

Journal Article

Weigert, R.; Hetzel, S.; Bailly, N.; Haggerty, C.; Ilik, I. A.; Kwong Yung, P. Y.; Navarro, C.; Bolondi, A.; Sampath Kumar, A.; Anania, C. et al.; Brändl, B.; Meierhofer, D.; Lupiáñez, D. G.; Müller, F.-J.; Aktas, T.; Elsässer, S. J.; Kretzmer, H.; Smith, Z. D.; Meissner, A.: Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nature Cell Biology 25 (4), pp. 579 - 591 (2023)

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2022

Review Article

Ilik, I. A.; Aktas, T.: Nuclear speckles: dynamic hubs of gene expression regulation. The FEBS Journal 289 (22), pp. 7234 - 7245 (2022)

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Journal Article

Bergfort, A.; Hilal, T.; Kuropka, B.; Ilik, I. A.; Weber, G.; Aktas, T.; Freund, C.; Wahl, M. C.: The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Research (London) 50 (5), pp. 2938 - 2958 (2022)

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Journal Article

Aktas, T.: Transposons: catch them if you can. Nature Reviews Molecular Cell Biology 23 (5), 306 (2022)

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Journal Article

Bergfort, A.; Preußner, M.; Kuropka, B.; Ilik, I. A.; Hilal, T.; Weber, G.; Freund, C.; Aktas, T.; Heyd, F.; Wahl, M. C.: A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing. Nature Communications 13 (1), Article 1132 (2022)

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2020

Journal Article

Ilik, I. A.; Malszycki, M.; Lübke, A. K.; Schade, C.; Meierhofer, D.; Aktas, T.: SON and SRRM2 are essential for nuclear speckle formation. eLife 9, Article e60579 (2020)

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Journal Article

Ilik, I. A.; Aktas, T.; Maticzka, D.; Backofen, R.; Akhtar, A.: FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research 48 (3), Article e15 (2020)

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Publications by Dr. Tuğçe Aktaş before 2018

Basilicata, M.F., Bruel, AL., Semplicio, G., Aktas T. et al.

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

Nat Genet. 2018

Daniel Maticzka, Ibrahim Avsar Ilik, Tugce Aktas, Rolf Backofen, Asifa Akhtar

uvCLAP is a fast and non-radioactive method to identify in vivo targets of RNA-binding proteins

Nature Communications volume 9 (2018)

Tuğçe Aktaş, İbrahim Avşar Ilık, Daniel Maticzka, Vivek Bhardwaj, Cecilia Pessoa Rodrigues, Gerhard Mittler, Thomas Manke, Rolf Backofen, Asifa Akhtar

DHX9 suppresses RNA processing defects originating from the Alu invasion of human genome

Nature volume 544 (2017)

Orsolya Symmons, Leslie Pan, Silvia Remeseiro, Tugce Aktas, Felix Klein, Wolfgang Huber, François Spitz

The Shh topological domain facilitates the action of remote enhancers by reducing the effects of genomic distances

Dev Cell. 2016

Tomasz Chelmicki, Friederike Dündar, Matthew James Turley, Tasneem Khanam, Tugce Aktas, Fidel Ramírez, Anne-Valerie Gendrel, Patrick Rudolf Wright, Pavankumar Videm, Rolf Backofen, Edith Heard, Thomas Manke, Asifa Akhtar

MOF-associated complexes ensure stem cell identity and Xist repression

Elife. 2014

Helen M Rowe, Marc Friedli, Sandra Offner, Sonia Verp, Daniel Mesnard, Julien Marquis, Tugce Aktas, Didier Trono

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

Development. 2013

Mirna Marinić, Tugce Aktas, Sandra Ruf, François Spitz

An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape

Developmental Cell. 2013

Helen M. Rowe, Johan Jakobsson, Daniel Mesnard, Jacques Rougemont, Séverine Reynard, Tugce Aktas, Pierre V. Maillard, Hillary Layard-Liesching, Sonia Verp, Julien Marquis, François Spitz, Daniel B. Constam, Didier Trono

KAP1 controls endogenous retroviruses in embryonic stem cells

Nature 2010