Max Planck Institute for Molecular Genetics

Publications

The following publications were published exclusively under the affiliation of the Max Planck Society. For publications by the principal investigator outside of the Max Planck Society, see the links on the lower left.

Journal Article (20)

Journal Article

Iyer, D. P.; Khoei , H. H.; van der Weijden, V. A.; Kagawa, H.; Pradhan, S. J.; Novatchkova, M.; McCarthy, A.; Rayon, T.; Simon, C. S.; Dunkel, I. et al.; Wamaitha, S. E.; Elder, K.; Snell , P.; Christie, L.; Schulz, E. G.; Niakan, K. K.; Rivron, N.; Bulut-Karslioglu, A.: mTOR activity paces human blastocyst stage developmental progression. Cell 187 (23), pp. 6566 - 6583 (2024)

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Schulz, E. G.; Martitz, A.: Structural remodeling of the inactive X chromosome during early mouse development. Nature Genetics 56 (10), pp. 2004 - 2005 (2024)

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Schulz, E. G.: BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding. Molecular Cell 84 (3), pp. 413 - 414 (2024)

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Ravid Lustig, L.; Sampath Kumar, A.; Schwämmle, T.; Dunkel, I.; Noviello, G.; Limberg, E.; Weigert, R.; Pacini, G.; Buschow, R.; Ghauri, A. et al.; Stötzel, M.; Wittler, L.; Meissner, A.; Schulz, E. G.: GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers. Nature Cell Biology 25 (11), pp. 1704 - 1715 (2023)

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de Sousa, J. A.; Wong, C.-W.; Dunkel, I.; Owens, T.; Voigt, P.; Hodgson, A.; Baker, D.; Schulz, E. G.; Reik, W.; Smith, A. et al.; Rostovskaya, M.; von Meyenn, F.: Epigenetic dynamics during capacitation of naïve human pluripotent stem cells. Science Advances 9 (39), eadg1936 (2023)

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Sultana, Z.; Dorel, M.; Klinger, B.; Sieber, A.; Dunkel, I.; Blüthgen, N.; Schulz, E. G.: Modeling unveils sex differences of signaling networks in mouse embryonic stem cells. Molecular Systems Biology 19 (11), e11510 (2023)

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Noviello, G.; Gjaltema, R. A. F.; Schulz, E. G.: CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Nature Communications 14 (1), 3225 (2023)

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Gjaltema, R. A. F.; Schwämmle, T.; Kautz, P.; Robson, M.; Schöpflin, R.; Ravid Lustig, L.; Brandenburg, L.; Dunkel, I.; Vechiatto, C.; Ntini, E. et al.; Mutzel, V.; Schmiedel, V.; Marsico, A.; Mundlos, S.; Schulz, E. G.: Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus. Molecular Cell 82 (1), pp. 190 - 208 (2022)

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Pacini, G.; Dunkel, I.; Mages, N.; Mutzel, V.; Timmermann, B.; Marsico, A.; Schulz, E. G.: Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution. Nature Communications 12 (1), 3638 (2021)

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Genolet, O.; Monaco, A. A.; Dunkel, I.; Boettcher, M.; Schulz, E. G.: Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach. Genome Biology 22, 110 (2021)

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Mutzel, V.; Schulz, E. G.: Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation. Bioessays 42 (4), e1900163 (2020)

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Barros de Andrade e Sousa, L.; Jonkers, I.; Syx, L.; Dunkel, I.; Chaumeil, J.; Picard, C.; Foret, B.; Chen, C.-J.; Lis, J. T.; Heard, E. et al.; Schulz, E. G.; Marsico, A.: Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Research 29 (7), pp. 1087 - 1099 (2019)

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Mutzel, V.; Okamoto, I.; Dunkel, I.; Saitou, M.; Giorgetti, L.; Heard, E.; Schulz, E. G.: A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structural and Molecular Biology 26 (5), pp. 350 - 360 (2019)

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supplementary-material

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Schulz, E. G.: X-chromosome dosage as a modulator of pluripotency, signalling and differentiation? Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 372 (1733), pii: 20160366 (2017)

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Zhan, Y.; Mariani, L.; Barozzi, I.; Schulz, E. G.; Blüthgen, N.; Stadler, M.; Tiana, G.; Giorgetti, L.: Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Research 27 (3), pp. 479 - 490 (2017)

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Schulz, E. G.; Meisig, J.; Nakamura, T.; Okamoto, I.; Sieber, A.; Picard, C.; Borensztein, M.; Saitou, M.; Blüthgen, N.; Heard, E.: The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network. Cell Stem Cell 14 (2), pp. 203 - 2016 (2014)

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Schulz, E. G.; Heard, E.: Role and control of X chromosome dosage in mammalian development. Current Opinion in Genetics & Development 23 (2), pp. 109 - 115 (2013)

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Nora, E. P.; Lajoie, B. R.; Schulz, E. G.; Giorgetti, L.; Okamoto, I.; Servant, N.; Piolot, T.; van Berkum, N. L.; Meisig, J.; Sedat, J. et al.; Gribnau, J.; Barillot, E.; Blüthgen, N.; Dekker, J.; Heard, E.: Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 485 (7398), pp. 381 - 385 (2012)

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Schulz, E. G.; Nora , E. P.; Heard, E.: Rnf12—A Jack of All Trades in X Inactivation? PLoS Genetics 7 (1), e1002002 (2011)

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Schulz, E. G.; Mariani, L.; Radbruch, A.; Höfer, T.: Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12. Immunity 30 (5), pp. 673 - 683 (2009)

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