Molecular networks in genome and proteome analysis
Research report (imported) 2014 - Max Planck Institute for Molecular Genetics
Molecular networks are data-based descriptions of molecular interactions in a cell. Today, a wealth of physiologically relevant protein information is available, obtained from cells under different conditions, from different systems or disease states, including information on genetic variation, protein levels, and post-translational modification. Molecular networks are useful frameworks to distinguish causal from other molecular alterations that are only consequence or do not substantially contribute to the phenotype. This way, molecular networks are also increasingly important for medicine.