Publications of L. Wittler

Will , A. J.; Cova, G.; Osterwalder, M.; Chan, W. L.; Wittler, L.; Brieske, N.; Heinrich, V.; de Villartay, J. P.; Vingron, M.; Klopocki, E. et al.; Visel, A.; Lupianez, D. G.; Mundlos, S.: Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog). Nature Genetics 49 (10), pp. 1539 - 1545 (2017)

Koch, F.; Scholze, M.; Wittler, L.; Schifferl, D.; Sudheer, S.; Grote, P.; Timmermann, B.; Macura, K.; Herrmann, B. G.: Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Developmental Cell 42, pp. 514 - 526 (2017)

Lange, L.; Marks, M.; Liu, J.; Wittler, L.; Bauer, H.; Piehl, S.; Bläß, G.; Timmermann, B.; Herrmann, B. G.: Pattering and gastrulation deffects caused by the tw18 lethal are due to loss of Ppp2r1a. Biology Open 6 (6), pp. 752 - 764 (2017)

Franke, M.; Ibrahim, D.; Andrey, G.; Schwarzer, W.; Heinrich, V.; Schöpflin, R.; Kraft, K.; Kempfer, R.; Jerković, I.; Chan, W.-L. et al.; Spielmann, M.; Timmermann, B.; Wittler, L.; Kurth, I.; Cambiaso, P.; Zuffardi, O.; Houge, G.; Lambie, L.; Brancati, F.; Pombo, A.; Vingron, M.; Spitz, F.; Mundlos, S.: Formation of novel chromatin domains determines pathogenicity of genomic duplications. Nature 538 (7624), pp. 265 - 269 (2016)

Sudheer, S.; Liu, J.; Marks, M.; Koch, F.; Anurin, A.; Scholze, M.; Senft, A. D.; Wittler, L.; Macura, K.; Grote, P. et al.; Herrmann, B. G.: Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm. Stem Cells 34 (7), pp. 1790 - 800 (2016)

Spielmann, M.; Kakar, N.; Tayebi, N.; Leettola, C.; Nürnberg, G.; Sowada, N.; Lupiáñez, D. G.; Harabula, I.; Flöttmann, R.; Horn, D. et al.; Chan, W. L.; Wittler, L.; Yilmaz, R.; Altmüller, J.; Thiele, H.; van Bokhoven,, H.; Schwartz, C. E.; Nürnberg, P.; Bowie, J. U.; Ahmad, J.; Kubisch, C.; Mundlos, S.: Exome Sequencing and CRISPR/Cas Genome Editing Identify Mutations of ZAK as a Cause of Limb Defects in Humans and Mice. Genome Research 26 (2), pp. 183 - 191 (2016)

Marks, M.; Pennimpede, T.; Lange, L.; Grote, P.; Herrmann, B. G.; Wittler, L.: Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene 575 (2 Pt 2), pp. 438 - 451 (2016)

Lupiáñez, D. G.; Kraft, K.; Heinrich, V.; Krawitz, P.; Brancati, F.; Klopocki, E.; Horn, D.; Kayserili, H.; Opitz, J. M.; Laxova, R. et al.; Santos-Simarro, F.; Gilbert-Dussardier, B.; Wittler, L.; Borschiwer, M.; Haas, S. A.; Osterwalder, M.; Franke, M.; Timmermann, B.; Hecht, J.; Spielmann, M.; Visel, A.; Mundlos, S.: Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions. Cell 161 (5), pp. 1012 - 1025 (2015)

Kraft, K.; Geuer, S.; Will, A. J.; Chan, W. L.; Paliou, C.; Borschiwer, M.; Harabula, I.; Wittler, L.; Franke, M.; Ibrahim, D. et al.; Kragesteen, B. K.; Spielmann, M.; Mundlos, S.; Lupianez, D. G.; Andrey, G.: Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice. Cell Reports 10 (5), pp. 833 - 839 (2015)

Reutter, H.; Draaken, M.; Pennimpede, T.; Wittler, L.; Brockschmidt, F. F.; Ebert, A. K.; Bartels, E.; Rösch, W.; Boemers, T. M.; Hirsch, K. et al.; Schmiedeke, E.; Meesters, C.; Becker, T.; Stein, R.; Utsch, B.; Mangold, E.; Nordenskjöld, A.; Barker, G.; Kockum, C. C.; Zwink, N.; Homdahl, G.; Läckgren, G.; Jenetzky, E.; Feitz, W. F.; Marcelis, C.; Wijers, C. H.; Van Rooij, I. A.; Gearhart, J. P.; Herrmann, B. G.; Ludwig, M.; Boyadjiev, S. A.; Nöthen, M. M.; Mattheisen, M.: Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder. Human Molecular Genetics 23 (20), pp. 5536 - 5544 (2014)

Schwartz, B.; Marks, M.; Wittler, L.; Werber, M.; Währisch, S.; Nordheim, A.; Herrmann, B. G.; Grote, P.: SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mechanisms of Development 133, pp. 23 - 35 (2014)

Draaken, M.; Baudisch, F.; Timmermann, B.; Kuhl, H.; Kerick, M.; Proske, J.; Wittler, L.; Pennimpede, T.; Ebert, A. K.; Rösch, W. et al.; Stein, R.; Bartels, E.; von Lowtzow, C.; Boemers, T. M.; Herms, S.; Gearhart, J. P.; Lakshmanan, Y.; Kockum, C. C.; Holmdahl, G.; Läckgren, G.; Nordenskjöld, A.; Boyadjiev, S. A.; Herrmann, B. G.; Nöthen, M. M.; Ludwig, M.; Reutter, H.: Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region. Birth Defects Research Part A: Clinical and Molecular Teratology 100 (6), pp. 512 - 517 (2014)

Werber, M.; Wittler, L.; Timmermann, B.; Grote, P.; Herrmann, B. G.: The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development 141 (11), pp. 2325 - 2330 (2014)

Müller, D.; Cherukuri, P.; Henningfeld, K.; Poh, C. H.; Wittler, L.; Grote, P.; Schlüter, O.; Schmidt, J.; Laborda, J.; Bauer, S. R. et al.; Brownstone, R. M.; Marquardt, T.: Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution. Science 343 (6176), pp. 1264 - 1266 (2014)

Hilger, A.; Schramm, C.; Pennimpede, T.; Wittler, L.; Dworschak, G. C.; Bartels, E.; Engels, H.; Zink, A. M.; Degenhardt, F.; Müller, A. M. et al.; Schmiedeke, E.; Grasshoff-Derr , S.; Märzheuser, S.; Hosie, S.; Holland-Cunz , S.; Wijers, C. H.; Marcelis, C. L.; van Rooij , I. A.; Hildebrandt, F.; Hermann, B. G.; Nöthen, M. M.; Ludwig, M.; Reutter, H.; Draaken, M.: De novo microduplications at 1q41, 2q37.3, and 8q24.3 in patients with VATER/VACTERL association. European journal of human genetics: EJHG ; the official journal of the European Society of Human Genetics 21 (12), pp. 1377 - 1382 (2013)

Grote, P.; Wittler, L.; Hendrix, D.; Währisch, S.; Beisaw, A.; Macura, K.; Bläss, G.; Kellis, M.; Werber, M.; Herrmann, B. G.: The tissue-specific IncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Developmental Cell 24 (2), pp. 206 - 214 (2013)

Pennimpede, T.; Proske, J.; Koenig, A.; Vidigal, J. A.; Morkel, M.; Bramsen, J. B.; Herrmann, B. G.; Wittler, L.: In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome. Developmental Biology 372 (1), pp. 55 - 67 (2012)

Spielmann, M.; Brancati, F.; Krawitz, P. M.; Robinson, P. N.; Ibrahim, D. M.; Franke, M.; Hecht, J.; Lohan, S.; Dathe, K.; Nardone, A. M. et al.; Ferrari, P.; Landi, A.; Wittler, L.; Timmermann, B.; Chan, D.; Mennen, U.; Klopocki, E.; Mundlos, S.: Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus. American Journal of Human Genetics 91 (4), pp. 629 - 635 (2012)

Wittler, L.; Hilger, A.; Proske, J.; Pennimpede, T.; Draaken, M.; Ebert, A.-K.; Rösch, W.; Stein, R.; Nöthen, M. M.; Reutter, H. et al.; Ludwig, M.: Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias. Gene 506 (2), pp. 392 - 395 (2012)

Qi, L.; Chen, K.; Hur, D. J.; Yagnik, G.; Lakshmanan, Y.; Kotch, L. E.; Ashrafi, G. H.; Martinez-Murillo, F.; Kowalski, J.; Naydenov, C. et al.; Wittler, L.; Gearhart, J. P.; Draaken, M.; Reutter, H.; Ludwig, M.; Boyadjiev, S. A.: Genome-wide expression profiling of urinary bladder implicates desmosomal and cytoskeletal dysregulation in the bladder exstrophy-epispadias complex. International Journal of Molecular Medicine 27 (6), pp. 755 - 65 (2011)